09/26/21 News Properties and Exciting Facts About Thiazole-4-carboxaldehyde

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N,O-acetals are important structures found in many bioactive natural products, and this unique organic functional group can serve as a useful synthetic precursor to the unstable N-acylimines. In this paper, a convenient route to synthesize N-carbamoyl-N,O-acetals and N-acyl-N,O-acetals from enecarbamates and enamides in the presence of alcohols as the solvents and nucleophile sources under Br°nsted acid conditions was reported. This strategy could be used to prepare various N,O-acetals from a range of enecarbamates and enamides with light alcohols, and the products are obtained in good yields (52?98%).

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare