Synthetic Route of 894493-95-9. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 894493-95-9, Name is (1S,2S)-N1,N1-Dimethylcyclohexane-1,2-diamine. In a document type is Article, introducing its new discovery.
A highly efficient organocatalytic method for the asymmetric Michael addition of alpha-substituted cyanoacetates to vinyl sulfones was investigated. It was observed that this reaction was synergistically promoted by readily available bifunctional thiourea-tertiary amine organocatalysts, giving an efficient protocol for the construction of an all-carbon substituted quaternary stereocentre at the prochiral nucleophiles. It was shown that the addition products could be smoothly converted to the enantiomerically pure beta-amino acids. It was found that this was the first enantioselective catalytic reaction which might involve a double-hydrogen bonding interaction between the NH of thiourea and a sulfone functionality.
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