Month: August 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63126-47-6,(S)-2-(Methoxymethyl)pyrrolidine,as a common compound, the synthetic route is as follows.,63126-47-6

General procedure: A mixture of aldehyde (1.97 mmol), amine (1.97 mmol), acetylene (2.95 mmol), and thecorresponding supported Au catalyst (1percent wt, 60 mg, 0.002 mmol) was heated at 60 ¡ãC for 8 h,after which time the solution was cooled and the catalyst was removed by filtration. The filtrate wasevaporated under reduced pressure to afford propargylamine 5. Yields were determined by integration of the 1H-NMR spectra of the crude reaction mixtures. After separation and washing with n-pentane,the catalyst was reused intact for the next reaction without any further pre-treatment.

The synthetic route of 63126-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Soengas, Raquel; Navarro, Yolanda; Iglesias, Maria Jose; Lopez-Ortiz, Fernando; Molecules; vol. 23; 11; (2018);,
Chiral Catalysts
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141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of pyrazine ligand 1 or 2 (1mmol), Li2PdCl4 (1mmol) and NaOAc (1mmol) in 20mL of dry methanol was stirred for 24hat rt. The yellow solids (yield: 92%) were collected by filtration and washed several times with methanol, which can be assigned to be palladacyclic dimers. Then, a Schlenk tube was charged with the above chloride-bridged palladacyclic dimers (0.5mmol), the corresponding imidazolium salt (1.25mmol) and tBuOK (2.5mmol) under nitrogen. Dry THF was added by a cannula and stirred at room temperature for 3h. The product was separated by passing through a short silica gel column with CH2Cl2 as eluent, the third band was collected and afforded the corresponding carbene adducts 3-10 as yellow solids. The characterization data for 3: Yield: 78%., 141556-45-8

141556-45-8 1,3-Dimesityl-1H-imidazol-3-ium chloride 2734211, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Xu, Chen; Wang, Zhi-Qiang; Fu, Wei-Jun; Ji, Bao-Ming; Yuan, Xiao-Er; Han, Xin; Xiao, Zhi-Qiang; Hao, Xin-Qi; Song, Mao-Ping; Journal of Organometallic Chemistry; vol. 777; (2015); p. 1 – 5;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.

Finely powdered (CH3CN)2PdCl2 (259 mg, 1.00 mmol) was suspended in CH3CN (5 mL) and 2-benzylpyridine (170 muL, 178 mg, 1.05 mmol) was added. The solution was heated to 8O0C for 5 min and finely powdered K2CO3 (691 mg, 5.00 mmol) was added. The stirring was continued until palladacycle formation was complete, as indicated by the formation of a canary yellow solution (5-10 min). IPrHCl (467 mg, 1.10 mmol) was added and the mixture was stirred at 8O0C over 18h. The reaction mixture was filtered and evaporated. The resulting product was purified by column chromatography. Upon application of the product to a pad of silica gel (2.5 x 8 cm) pre-equilibrated with CH2CI2, CH2CI2 (100 mL) was used to elute impurities. The pure NHC-palladacycles were eluted with CH2Cl2-ethylacetate (1:1, vol/vol, 150 mL) and the solvents were evaporated. The products triturated with hexanes (25 mL). After drying in high vacuum, 2-PhPy] (464 mg, 66%) was obtained as yellow solid. 1H NMR (CDCl3, 400 MHz) delta:8.80 (d, J= 0.8 Hz, IH)5 7.56 (broad m, IH), 7.42 (broad m5 4H), 7.20 (s, 2H)5 7.07 (d, J = 7.6, 2H)5 7.01 (broad m, IH)5 6.89 (t, J= 6.8 Hz5 IH)5 6.74-6.68 (m, 3H)5 6.61 (m5 IH)5 3.79-3.76 (broad m, 2H), 3.37 (broad m, 3H), 2.37 (broad m, IH), 1.64 (broad S5 3H), 1.54 (broad s 3H), 1.30 (broad s, 3H), 1.22 (broad s, 3H)5 1.00 (broad s, 3H)5 0.95 (broad S5 3H)5 0.42 (broad s, 3H). 13C NMR (CDCl3, 100 MHz) delta: 176.I5 159.4, 153.2, 150.1, 149.6, 148.2 (broad), 147.5 (broad), 145.4 (broad), 140.2, 137.3, 136.5 (broad), 136.0 (broad), 130.0 (broad), 129.4 (broad), 125.7, 125.2 (broad), 125.O5 124.6 (broad), 124.2 (broad), 123.6 (broad), 123.0 (broad), 122.3, 121.1, 49.2, 28.9, 28.8, 26.7, 26.3, 24.0, 23.2.

250285-32-6, As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

Reference£º
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; WO2008/156451; (2008); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

Benzo-18-crown 6-Ether, cas is 14098-24-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,14098-24-9

A mixture of 3a (1 mmol) and benzo[18]krown-6 (312 mg, 1 mmol) in trifluoroacetic acid (2 mL) was kept for 24 h at room temperature. The solvent was removed under reduced pressure. The residue was diluted in aqueous ethanol and neutralized with a triethylamine to pH = 7. The obtained solution was stayed for 3 days in an open vessel. The precipitated product was separated by filtration and washed three times with water (3 * 5 mL) and dried in vacuo at 120 C. Yellow crystals; Yield 50%; Mp 240-242 C. 1H NMR (400 MHz, DMSO-d6) delta 8.66 (s, 1H), 8.48 (dd, J = 8.0, 2.0 Hz, 1H), 8.23 (d, J = 2.0 Hz, 1H), 7.22 (d, J = 8.0 Hz, 1H), 4.24-4.20 (m, 4H), 3.86-3.80 (m, 4H), 3.67-3.62 (m, 4H), 3.62-3.60 (m, 4H), 3.55 (s, 4H). 13C NMR (101 MHz, DMSO-d6+CCl4) delta 154.58, 154.04, 153.99, 152.08, 148.14, 143.60, 129.32, 126.68, 124.18, 112.45, 69.91, 69.77, 69.69, 68.57, 68.49, 68.22. Anal. Calcd. For C21H25N7O6: C, 53.50; H,5.34; N, 20.80. Found: C, 53.42; H, 5.47; N, 20.73.

With the rapid development of chemical substances, we look forward to future research findings about 14098-24-9

Reference£º
Article; Gorbunov, Evgeny B.; Rusinov, Gennady L.; Ulomsky, Evgeny N.; Rusinov, Vladimir L.; Charushin, Valery N.; Chupakhin, Oleg N.; Tetrahedron Letters; vol. 57; 21; (2016); p. 2303 – 2305;,
Chiral Catalysts
Chiral catalysts – SlideShare

6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol), cas is 351498-10-7, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,351498-10-7

N,N-Bis(3,5-di-tert-butylsalicylidene)-1 ,1 ,2,2-tetramethylethylenediamine (24, 0.73 g, 1 .3 mmol)was suspended in 10.0 mL of ethanol. The resulting suspension was heated to 80 c and stirred for 5minutes under argon balloon. Cobalt (II) acetate (0.24g, 1 .3 mmol) was then added, and the reactionmixture was stirred for another 2 hours at 80 00. The crimson red suspension was cooled down to roomtemperature in an ice bath and was filtered. The collected red solid was dried under vacuum to provide0.70 g of compound 25 (87%).

With the rapid development of chemical substances, we look forward to future research findings about 351498-10-7

Reference£º
Patent; SOLSTICE BIOLOGICS, LTD.; BRADSHAW, Curt, W.; SAKAMURI, Sukumar; LIU, Dingguo; (83 pag.)WO2016/94677; (2016); A2;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63126-47-6,(S)-2-(Methoxymethyl)pyrrolidine,as a common compound, the synthetic route is as follows.,63126-47-6

1-Tert-Butyl-5- (4-methyl-benzoylamino)-1 H-pyrazolo [3,4-d] thiazole-3- carboxylic acid (50 mg, 0.14 mmoles) was dissolved in 10 ml of anhydrous tetrahydrofuran. Then, 1-hydroxybenzotriazole (23 mg, 0. 168 mmoles) was added followed by addition of N- cyclohexylcarbodiimide N’-methyl polystyrene (155 mg, 0.28 mmoles, loading: 1.8 mmoles/g) and S-2-methoxymethyl pyrrolidine (22 mg, 0.14 mmoles). The mixture was heated at 50¡ãC for overnight. Polymer supported triamine (100 mg, 0.417 mmoles, loading: 4.17 mmoles/g) was added and shaken for 4 hours at 50¡ãC. The resin was filtered off and washed with tetrahydrofuran (2 x 5ml). The filtrate was evaporated in vacuo to give crude product, which was purified by preparative HPLC using MeOH/H2O/TFA solvent system. The combined pure fractions were evaporated in vacuo and further dried on lyophilizer (yield: 36percent, LC: Method A, RT = 4.020 min, MS: M+1 = 456).

The synthetic route of 63126-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LEXICON GENETICS, INC; WO2005/95420; (2005); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride, cas is 173035-10-4, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,173035-10-4

To a suspension of SIMes¡¤HCl (906mg, 2.64mmol) in THF (30mL) was added dropwise a 1.6M solution of n-butyl lithium in hexanes (1.65mL, 2.64mmol) at-78C with stirring. After 10min, the suspension was allowed to warm to room temperature for additional 10min. The mixture was cooled again to-78C and then treated with a cooled THF solution (-78C) of mesitylcopper (504mg including 0.09 equivalents of toluene, determined by 1H NMR, 2.64mmol) by means of a cannula. The reaction mixture was allowed to warm to room temperature and stirred for further 18h. The solvents were removed under reduced pressure. The resulting solid residue was dried for 2h and then extracted with toluene (50mL). The suspension was filtered through Kieselgur and the filter cake was washed with small portions of toluene (5mL). The resulting solution was concentrated under reduced pressure to 15mL and then stored at-18C for 18h while large colorless crystals were forming. The mother liquor was decanted from the crystals that were subsequently washed with cold toluene (5mL) and dried in vacuo for 15h. The mother liquor was combined with the washing solution, concentrated to 5mL and stored at-18C for about 3 weeks. From this solution a second crop of colorless crystals was isolated. Combined yield: 1.032g (2.11mmol, 80%). Anal. Calcd for C30H37N2Cu: C, 73.66; H, 7.62; N, 5.73. Found: C, 72.87; H, 7.91; N, 5.72. 1H NMR (500.13MHz, C6D6): delta 2.12 (s, 6H, p-CH3, NHC), 2.15 (s, 6H, o-CH3, CuMes), 2.18 (s, 12H, o-CH3, NHC), 2.26 (s, 3H, p-CH3, CuMes), 3.05 (s, 4H, CH2), 6.76 (s, 4H, CH, NHC), 6.86 (s, 2H, CH, CuMes). 13C NMR (125.77MHz, C6D6): delta 18.1 (o-CH3, NHC), 21.0 (p-CH3, NHC), 21.6 (p-CH3, CuMes), 28.0 (o-CH3, CuMes), 50.4 (CH2), 124.5 (CH, CuMes), 129.6 (CH, NHC), 132.7 (C, CuMes), 136.0, 136.2, 138.2 (3¡ÁC, Mes, NHC), 147.2 (C, CuMes), 163.7 (C, CuMes), 207.1 (C, CN2, NHC). MS (ESI in THF): m/z (rel. intensity)=675 (100) [(NHC)2Cu]+, 857 (34) [(NHC)2Cu2Mes]+; MS (ESI in CH3CN): m/z (rel. intensity)=764 (63) [(NHC)2Cu2(CN)]+, 675 (80) [(NHC)2Cu]+, 410 (42) [(NHC)Cu(CH3CN)]+, 397 (100) [(NHC)Cu(CO)]+, 369 (8) [(NHC)Cu]+, 307 (11) [(Mes)2(C3H4N2)+1]+. IR (KBr, cm-1): 3003, 2949, 2916, 2855, 2729, 2706, 1775, 1742, 1730, 1609, 1589, 1487, 1474, 1439, 1375, 1317, 1306, 1298, 1263, 1215, 1173, 1161, 1032, 1013, 951, 914, 883, 851, 839, 754, 741, 733, 721, 706, 689, 615, 602, 588, 573, 550, 532, 502, 482, 465, 419.

With the rapid development of chemical substances, we look forward to future research findings about 173035-10-4

Reference£º
Article; Stollenz, Michael; Fischer, Stefan; Gehring, Henrike; Resch, Stefan G.; Dechert, Sebastian; Grosse, Christian; Meyer, Franc; Journal of Organometallic Chemistry; vol. 821; (2016); p. 106 – 111;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33100-27-5,1,4,7,10,13-Pentaoxacyclopentadecane,as a common compound, the synthetic route is as follows.

[(15-Crown-5)Na][Br] Used in CORM-365; 1.070 g (4.86 mmol) of 15-Crown-5 (commercially available) and 500 mg (3.78 mmol) of NaBr were stirred together in 15 ml: of methanol at 50¡ã C. for 3 hrs. Following this, the solvent was removed on rotary, evaporator to give a solid product that was washed several times with ether and then dried under vacuum.1.317 g of a white solid was obtained. Yield was 83.9percent., 33100-27-5

As the paragraph descriping shows that 33100-27-5 is playing an increasingly important role.

Reference£º
Patent; Motterlini, Roberto Angelo; Mann, Brian Ernest; Scapens, David Alistair; US2010/105770; (2010); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

(R)-2′-amino-[1,1′-binaphthalen]-2-ol, cas is 137848-28-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,137848-28-3

To a magnetically stirred solution of R-(+)-2-amino-1,1′-binaphthalen-2-ol (0.206 g, 0.722 mmol) in DMAC (15 mL) was slowly added a solution of terephthaloyl chloride (0.0733 g, 0.361 mmol) in DMAC (10mL). After the addition was complete, the reaction mixture was stirred at room temperature for 24h and then concentrated in vacuo to give a crude tan solid. The solid was dissolved in CHCl3 (300 mL) and washed with water (3¡Á100 mL) and brine (50 mL). The organic phase was dried over anhydrous sodium sulfate and then concentrated in vacuo to furnish monomer 3RR (85% yield) as a light tan powder. mp: >250C (decomposition). 1H NMR (DMSO-d6, 500MHz) delta 9.74 (s, 2H), 8.83 (s, 2H), 8.15-8.18 (m, 2H), 8.03-8.07 (m, 2H), 7.97-8.02 (m, 4H), 7.91-7.95 (m, 2H), 7.43-7.48 (m, 2H), 7.37-7.41 (m, 2H), 7.24-7.33 (m, 4H), 7.09-7.17 (m, 8H), 6.86-6.90 (m, 2H); MS m/e: 701.24 ([M]H+). [alpha]D=(+)76 (c=0.130g/dL, THF).

With the rapid development of chemical substances, we look forward to future research findings about 137848-28-3

Reference£º
Article; Lynch, Joseph G.; Jaycox, Gary D.; Polymer; vol. 55; 16; (2014); p. 3564 – 3572;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22795-99-9,(S)-(1-Ethylpyrrolidin-2-yl)methanamine,as a common compound, the synthetic route is as follows.

22795-99-9, To a mixture of cyanuric chloride (0.368 g, 2 mmol) inCH3CN atabout-20 C was added3-fluoro-p-anisidine (0.28 g, 2 mmol) inCH3CN followed by the additionof N, N-diisopropylethylamine (DIEA) (0.35 mL, 2 mmol) and stirred for about 1 hour. The reaction mixture was then stirred at room temperature for about 1 hour. Then, cyclohexylmethyl amine (0.26mL, 2 mmol) and DIEA (0.35 mL, 2 mmol) were added and the reaction mixture was stirred overnight at RT. Then, S-(-)- 2-aminomethyl-N-ethyl pyrrolidine (0.29 mL, 2 mmol) and DIEA (0.35 mL, 2 mmol) were added and the reaction mixture was refluxed overnight. The reaction mixture was diluted with ethyl acetate and washed with brine. The organic layer was separated and dried over sodium sulfate, filtered, and concentrated under reduced. The crude material was purified by column chromatography eluting with 96: 3: 1 methylene chloride: methanol: cone. ammonium hydroxide to yield a white solid 141 (0.400 g, 43.7percent), mp68-69 OC ; HPLC: Inertsil ODS-3V C18, 40: 30: 30[KH2P04(0. 01 M, pH3. 2) :CH30H : CH3CN], 264nm, Rt 8.2 min, 97.1percent purity ; MS (ESI):lnlz 458 (M+H, 100), 362 (2.8), 230(85. 4).

22795-99-9 (S)-(1-Ethylpyrrolidin-2-yl)methanamine 643457, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; REDDY US THERAPEUTICS, INC.; WO2004/26844; (2004); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare