Day: August 19, 2020

173035-10-4, 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of 383.0 mg (1.08 mmol) of 1,3-bis(2,4,6-trimethylphenyl)-imidazolidinium chloride (commercially available from Aaron Chemistry GmbH, D-85386 Eching) and 0.67 ml (1.14 mmol) of potassium tert.-pentylate (1.7 M in toluene) was suspended in 25 ml hexane and heated at 50 C. for 10 min. A suspension of 500.0 mg (0.54 mmol) of [RuCl2(PCy3)2(3-phenyl-indenylidene)] (commercially available from Umicore AG, D-63457 Hanau-Wolfgang) in 16 ml of hexane was added and the resulting red suspension stirred at 50 C. for 18 h. The reaction mixture was evaporated to dryness and the isolated crude product purified by silica gel chromatography (hexane/diethylether 6:4) to yield 257.0 mg (50%) of the title compound as red crystals. MS: 948.3 (M+). 31P-NMR (121 MHz, C6D6): 25.8 ppm; 1H-NMR (300 MHz, C6D6): 1.00-1.40 (m, 18H); 1.45-1.64 (m, 6H); 1.65-1.95 (m, 6H); 1.80 (s, 3H); 2.23 (s, 6H); 2.38 (s, 3H); 2.85 (s, 3H); 2.87 (s, 3H); 3.10-3.45 (m, 4H); 6.02 (s, 1H); 6.47 (s, 1H); 6.97 (s, 2H); 7.05-7.35 (m, 6H); 7.84 (s, 1H, RuCCH); 7.89 (m, 2H); 9.16 (m, 1H). Anal. calcd. for C54H69N2Cl2PRu: C, 68.34; H, 7.33; N, 2.95. Found: C, 68.61; H, 7.32; N, 2.68.

As the paragraph descriping shows that 173035-10-4 is playing an increasingly important role.

Reference£º
Patent; Puentener, Kurt; Scalone, Michelangelo; US2006/241156; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.602-09-5,[1,1′-Binaphthalene]-2,2′-diol,as a common compound, the synthetic route is as follows.

Example 15: Separation of (S)-1 , 1 ‘-bi-2-naphthol from (RS)-1 ,1′-bi-2-naphthol via formation of binary/ternary co-crystal with 3-alkyl-4-(1′-phenylethylamino)butanoic acid. 3-alkyl-4-(1′-phenylethylamino)butanoic acid (0.385 moles) was dissolved in methanol (five volumes) and (RS)-1 ,1′-bi-2-naphthol (0.35 moles, i.e. 100 g) was added to it at room temperature. The mixture was stirred at 50 C for 2 hour, during which time solid precipitate came out from the reaction mixture. Reaction mixture was allowed to cool to room temperature and filtered under reduced pressure to obtain solid co-crystal.Co-crystal was suspended in methanol (five volumes) and stirred at 50 C for 2 h. After which reaction mixture was cooled to room temperature and filtered under reduced pressure to obtain pure solid co-crystal.Pure co-crystal was suspended in a biphasic mixture of ethyl acetate (2.5 volumes) and 1Lambda/ hydrochloric acid (2.5 volumes) and stirred for 30 to 45 min to decompose the complex. Aqueous phase was washed with 2 volumes of ethyl acetate. Organic phases were mixed together and washed with brine, followed by drying over sodium sulfate. Solvent was evaporated under vacuum to obtain optically pure (S)-1 ,1′-bi-2-naphthol which was analyzed for ee on chiral chromatography.Chiral chromatographic conditions for (S)-1.1′-bi-2-naphtholRetention time for (S)-1, 1′-bi-2-naphthol : 17.77 minRetention time for (R)-1, 1′-bi-2-naphthol : 20.64 minInstrument HPLC using a Shimadzu LC 2010 system equipped Pump, Injector, UV detector and Recorder Column: Chiral Pak IA, 4.6mm x 250mm, 5muiotaeta, column oven temperature 40 C Detector. UV at 230 nm.Mobile phase: n-hexane (94) :n-butanol (5) : ethanol (1): trifluoroacetic acid (0.3 mL) Flow rate: 1 mL minInjection volume: 20 muIota.Yield and enantiomeric excess of (S)-1 ,1′-bi-naphthol using various 3-alkyl-4-(1′- phenylethylamino)butanoic acids for co-crystal formation during resolution of (RS)-1 ,1 – bi-naphthol are tabulated below in table 4:Table 4* Data represented for antipode of (S)-1 ,1’-bi-naphthol.

As the paragraph descriping shows that 602-09-5 is playing an increasingly important role.

Reference£º
Patent; LUPIN LIMITED; ROY, Bhairab, Nath; SINGH, Girij, Pal; LATHI, Piyush, Suresh; MITRA, Rangan; WO2012/7814; (2012); A2;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22795-99-9,(S)-(1-Ethylpyrrolidin-2-yl)methanamine,as a common compound, the synthetic route is as follows.

Reaction 5:In the glovebox, 500 ?? of the stock solution was transferred to the vial called chamber 2 of our 2-chamber system. Then an injection vial with the 5A MS (750 mg) was installed in the chamber 2 and the system was sealed with a crimp-cap (Aluminium Cap 20mm, silicone/PTFE). Palladium catalysed [nC]carbonylation reactions was then run following the previous described protocol. 307 MBq of crude product was isolated after flushing of the 2-chamber system. Analytical HPLC was run on an aliquot of the crude (Phenomenex Luna 5? C18 100A, 250×4.6 mm 5 micron, 35percent Acetonitrile 65percent NaH2P04 70mM, 2 mL/min). The HPLC chromatogram from the radio-channel showed that the desired[nC]raclopride was 11percent radiochemically pure.

The synthetic route of 22795-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AARHUS UNIVERSITET; REGION MIDTJYLLAND; SKRYDSTRUP, Troels; LINDHARDT, Anders Thyboe; G?GSIG, Thomas; TAANING, Rolf Hejle; AUDRAIN, Helene; BENDER, Dirk Andreas; FRIIS, Stig Duering; WO2013/41106; (2013); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

673-06-3, D-Phenylalanine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A. Preparation of Nalpha-(4-methylbenzenesulfonyl)-D-phenylalanine D-phenylalanine was reacted with 4-methylbenzenesulfonyl chloride under the conditions used in general procedure A giving the title compound which was recrystallized from ether (18%). LC-MS: 318 (M-H)-, 98% pure.

673-06-3 D-Phenylalanine 71567, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; Stranix, Brent Richard; Sauve, Gilles; Bouzide, Abderrahim; Cote, Alexandre; Berube, Gervais; Soucy, Patrick; Zhao, Yongsen; Yelle, Jocelyn; US2002/151546; (2002); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

22795-99-9, (S)-(1-Ethylpyrrolidin-2-yl)methanamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.414 g (1 mmol) of compound 4a prepared in Preparation 9 was dissolved in 10 ml of anhydrous toluene, 0.39 ml of thionyl chloride was added, and the mixture was heated at 60 ¡ã C. under argon for 1 hour and then evaporated to dryness. 10 ml of anhydrous DCM was added,(S) -2-aminomethyl-1-ethylpyrrole 0.154g under ice-water bath, the reaction was stirred at room temperature for 8 hours, diluted with 50ml of EtOAc,Washed with saturated aqueous solution of NaHCO3, saturated NaCl three times, the organic layer was dried over Na2SO4, filtered and evaporated to give a yellowish oil,The residue was separated by a medium pressure silica gel column and the mobile phase petroleum ether: ethyl acetate 1: 1 (2percent TEA (triethylamine)). The product fractions were collected and evaporated to give 0.396 g as a yellowish oil, yield 75.6percent.

The synthetic route of 22795-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beijing Nerve Surgical Department Institute; Liu Qian; Zhang Yazhuo; Yang Xiaoxiao; CN106366075; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

22795-99-9, (S)-(1-Ethylpyrrolidin-2-yl)methanamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 100 mL eggplant bottle, 1.22 g of benzaldehyde, 30 mL of anhydrous ethanol,(S) -1-ethyl-2-aminomethyltetrahydropyrroline, and the mixture was heated under reflux for 24 hours.Adding 0.76 g of sodium borohydride, stirring for 3 hours, pouring into water, extracting the organic phase with dichloromethane,Dried over anhydrous magnesium sulfate, and the solvent was removed to obtain a pale yellow viscous liquid.30 mL of absolute ethanol, 0.6 g of paraformaldehyde, 2.06 g of 2,4-di-tert-butylphenol were added, and the mixture was heated under reflux for 12 hours.The crude product was chromatographed on silica gel to give colorless transparent liquid L2 (1.95 g, 44.7percent).

22795-99-9 (S)-(1-Ethylpyrrolidin-2-yl)methanamine 643457, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; East China University of Science and Technology; Ma, HaiYan; Wang, haobing; (35 pag.)CN103787943; (2016); B;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.351498-10-7,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),as a common compound, the synthetic route is as follows.

Compound Int-1a (733 mg, 1.33 mmol) was suspended in ethanol (10 mL) and the resulting suspension was heated to 80 C and allowed to stir for 5 minutes. Compound Int- 1b (236 mg, 1.33 mmol) was then added and the resulting reaction was allowed to stir at 80 C for an additional 2 hours. The reaction was then cooled to room temperature using in an ice bath and the reaction mixture was filtered. The collected red solid was dried under vacuum to provide compound Int-1c (579 mg, 72%).

351498-10-7 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) 135404188, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; GIRIJAVALLABHAN, Vinay; BOGEN, Stephane; TRUONG, Quang, T.; CHEN, Ping; KEREKES, Angela; BENNETT, Frank; ESPOSITE, Sara; HONG, Qingmei; DAVIES, Ian; WO2014/62596; (2014); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-22-8,trans-Cyclohexane-1,2-diamine,as a common compound, the synthetic route is as follows.

Into a solution containing 1,6-diisocyanatohexane (4.03 grams, 24 mmol; obtained from Sigma-Aldrich Fine Chemicals) and a 1:1 mixture of hexane and tetrahydrofuran (100 milliliters) stirring at room temperature was added a solution containing triethylene glycol monomethacrylate (5.24 grams, 24 mmol; obtained as CD570 from Sartomer Company Inc., Exton, Pa.) dissolved in a 1:1 mixture of hexane and tetrahydrofuran (10 milliliters) and dibutyltin dilaurate (0.075 grams, 0.12 mmol (obtained from Sigma-Aldrich Fine Chemicals) as the catalyst. The mixture was stirred and heated to an internal temperature of 40 C. The progress of the reaction was monitored by 1H-NMR spectroscopy for consumption of the triethylene glycol monomethacrylate reactant. The mixture was cooled to about 15 C. temperature, after which to this mixture was added dropwise a solution of trans-1,2-diaminocyclohexane (1.37 grams, 12 mmol; obtained as a racemic mixture of (1R,2R) and (1S,2S) stereoisomers from Sigma-Aldrich Fine Chemicals) dissolved in a 1:1 mixture of hexane and tetrahydrofuran (10 milliliters). The reaction mixture was stirred for 1 hour while warming up to room temperature. FTIR spectroscopic analysis of a reaction sample showed little unreacted isocyanate (peak at 2180 cm-1, sample prepared as a KBr pellet). Any residual isocyanate reagent was quenched by addition of methanol (5 milliliters). The reaction mixture was then filtered by vacuum filtration to give 6.13 grams of a solid product as a white powder (58 percent yield). 1H-NMR spectroscopic analysis of the solid was performed in DMSO-d6 (300 MHz) at room temperature (25 C.) and exhibited spectral assignments that matched those found for the compound in Example XVIII. The product was believed to be of the formulae

The synthetic route of 1121-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Xerox Corporation; US2006/122415; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-22-8,trans-Cyclohexane-1,2-diamine,as a common compound, the synthetic route is as follows.

General procedure: A methanolic solution (10mL) of (¡À)-trans-1,2-diaminocyclohexane (dach) (0.23g, 2.0mmol) in a Schlenk tube, was added dropwise to a methanolic solution (20mL) of salicylaldehyde-imidazolium salt H(iPr)sal(Me2Im+-X-) 3a-c (4.0mmol) into a 100mL Schlenk flask under nitrogen atmosphere. The reaction mixture was stirred under N2 at 60C for 3h. Then the solvent was partially removed under reduced pressure, and the yellow products of 4a-c were precipitated by the addition of ethyl acetate and kept in the refrigerator overnight. Solvent was decanted off and the obtained crude product was sonicated for 15min in Et2O (3¡Á25mL). Et2O was also decanted off and the residual solid was washed intensively with MeOH/Et2O mixture (1:2) to remove unreacted materials and then re-dissolved in MeOH. EtOAc was added slowly (?15min) to precipitate the products as pale yellow-dark orange solids which were collected by filtration and dried under vacuum. Samples of the isolated solids were characterized as follows.

The synthetic route of 1121-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Elshaarawy, Reda F.M.; Kheiralla, Zeinab H.; Rushdy, Abeer A.; Janiak, Christoph; Inorganica Chimica Acta; vol. 421; (2014); p. 110 – 122;,
Chiral Catalysts
Chiral catalysts – SlideShare

351498-10-7, 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound Int-1a (733 mg, 1.33 mmol) was suspended in ethanol (10 mL) and the resulting suspension was heated to 80 C. and allowed to stir for 5 minutes. Compound Int-1b (236 mg, 1.33 mmol) was then added and the resulting reaction was allowed to stir at 80 C. for an additional 2 hours. The reaction was then cooled to room temperature using in an ice bath and the reaction mixture was filtered. The collected red solid was dried under vacuum to provide compound Int-1c (579 mg, 72%).

As the paragraph descriping shows that 351498-10-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; Girijavallabhan, Vinay; Njoroge, F. George; Bogen, Stephane; Kerekes, Angela; Bennett, Frank; Huang, Ying; Nair, Latha; Pissarnitski, Dmitri; Verma, Vishal; Dang, Qun; Davies, Ian; Olsen, David B.; Stamford, Andrew; Vacca, Joseph P.; US2014/161770; (2014); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare