Day: August 21, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7181-87-5,1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide,as a common compound, the synthetic route is as follows.

A 20 mL of freshly dried THF was added to a mixture of Me2-bimy¡¤HI (0.40 g, 1.46 mmol) and KOtBu (0.13 g, 1.17 mmol), and the mixture was stirred in an ice-water bath for 2 h. The resulting dark yellow solution was filtered and removed under vacuum. The residue was washed with n-hexane several times and then 1,3-dimethylbenzimidazol-2-ylidene (Me2-bimy) was obtained (0.10 g, 0.68 mmol). A 15 mL THF was added to a mixture of [TeFe3(CO)9{Cu(MeCN)}2] (0.26 g, 0.34 mmol) and Me2-bimy (0.10 g, 0.68 mmol) in an ice-water bath, which was stirred for 15 min. The resulting solution was filtered, and the solvent was removed under vacuum. The residue was washed with deionized water and n-hexane several times and then extracted with Et2O to give a purplish-brown solution which was recrystallized with Et2O/CH2Cl2 to give [TeFe3(CO)9{Cu(Me2-bimy)}2] (1) as a purplish-black solid (0.154 g, 0.159 mmol, 47% based on [TeFe3(CO)9{Cu(MeCN)}2]). IR (nuCO, CH2Cl2): 2033 (m), 1976 (vs), 1920 (m), 1875 (w) cm-1. 1H NMR (500 MHz, DMSO-d6, 300 K, ppm): delta 7.69 (dd, 4H, Ar-H), 7.43 (dd, 4H, Ar-H), 4.02 (s, 12H; CH3).

7181-87-5 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide 11821793, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Shieh, Minghuey; Liu, Yu-Hsin; Li, Yu-Huei; Lin, Chien-Nan; Wang, Chih-Chin; Journal of Organometallic Chemistry; vol. 867; (2018); p. 161 – 169;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.351498-10-7,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),as a common compound, the synthetic route is as follows.

A 50 ml. flask was charged withLambda/,Lambda/-bis(3,5-di-te/t-butylsalicylidene)-1 ,1 ,2,2-tetramethylethenediamine (0.4302 g, 0.78 mmol, 1.0 equiv), EtOH (17 ml_), and Co(OAc)2 (0.1385 g, 0.78 mmol, 1.0 equiv). The mixture was degassed and then heated to reflux under nitrogen for 3 h, cooled to room temperature. The precipitate was filtered and the purple solid was washed with EtOH (10 ml.) and dried under high vacuum to give 0.3533 g (75%) of the cobalt(ll) complex.

As the paragraph descriping shows that 351498-10-7 is playing an increasingly important role.

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; CLAREMON, David, A.; LEFTHERIS, Katerina; ZHUANG, Linghang; TICE, Colin, M.; SINGH, Suresh, B.; YE, Yuanjie; WO2011/11123; (2011); A1;,
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137848-28-3, (R)-2′-amino-[1,1′-binaphthalen]-2-ol is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: This compound was prepared as a yellow solid from the reaction of pyridine-2-carboxaldehyde (1.07 g, 10.0 mmol) with (R)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g, 10.0 mmol) indry toluene (50 mL) in the presence of 4 A molecular sieves at 70 C and recrystallization from a toluene solution by a similar procedure as in the synthesis of 1H2. Yield: 2.99 g (80%). M.p.: 180-182 C. 1H NMR (C6D6): d 8.62 (s, 1H, CHN), 7.88 (s, 1H, aryl), 7.61 (m, 2H, aryl), 7.52 (m, 5H, aryl), 7.24 (d, J = 8.0 Hz, 1H, aryl), 7.10-6.95 (m, 5H, aryl), 6.56 (t, J = 6.8 Hz, 1H, aryl), 6.24 (m, 1H,aryl); the proton of the OH group was not observed. These spectroscopic data were in agreement with those reported in the literature [69].

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Reference£º
Article; Chen, Liang; Zhao, Ning; Wang, Qiuwen; Hou, Guohua; Song, Haibin; Zi, Guofu; Inorganica Chimica Acta; vol. 402; (2013); p. 140 – 155;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14098-24-9,Benzo-18-crown 6-Ether,as a common compound, the synthetic route is as follows.

General procedure: 4.2.1. Method A. molecular clip 2 was obtained in 50% yield as described6b Method B. A mixture of bisether 8 (1 g, 2.65 mmol) and corresponding benzocrown ether (5.42 mmol) in PPA (30 g) was stirred vigorously at 80-85 for 30 min. A deep purple color was formed in 5 min. To the cooled reaction mixture was added water (150 mL) and product was extracted with CHCl3 (3¡Á50 mL). The organic layer was washed with water until neutral (?3¡Á50 mL) and subjected to azeotropic drying. The solvent was removed at reduced pressure and the residue was dissolved in a mixture of CHCl3/MeOH (50:1, 100 mL) and filtered through SiO2 (~30 mL). The solvent was removed at reduced pressure and the crude product was purified as described below. Method C. The procedure is similar to Method B, with exception that tetraol 9 (1.1 g, 2.65 mmol) was used instead bisether 8. Method D. A suspension of NaH (0.288 g, 12 mmol) in DMSO (26 mL) was heated with stirring at 70 for 30 min. The resulting mixture was cooled to room temperature and a solution of 11 (0.78 g, 2.65 mmol) in DMSO (40 mL) was added. Stirring was continued for 20 min and then solution of 10 (5.92 g, 5.83 mmol) in DMSO (40 mL) was added dropwise over 5 min and the resulting mixture was stirred at room temperature for 24 h. The mixture was poured into ice water (400 mL) and acidified with HCl to pH~2. The resulting solid was filtered off, washed with water (3¡Á50 mL). The crude product was purified as described below.

The synthetic route of 14098-24-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bogaschenko, Tatiana Yu.; Lyapunov, Alexander Yu.; Kikot’, Leonid S.; Mazepa, Alexander V.; Botoshansky, Mark M.; Fonari, Marina S.; Kirichenko, Tatiana I.; Tetrahedron; vol. 68; 24; (2012); p. 4757 – 4764;,
Chiral Catalysts
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2133-34-8, (S)-Azetidine-2-carboxylic acid is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a round bottom flask was added (,S)-azetidine-2-carboxylic acid (63, 51 1 mg, 5.05 mmol) and sodium hydroxide (7.0 mL of IN; 7.08 mmol). The reaction was cooled to 0 C and 3,5-dichlorobenzenesulfonyl chloride (65, 1.36 g, 5.56 mmol) was added followed by N,N- diisopropylethylamine (1.0 mL, 5.81 mmol) and acetone (7 mL) and the reaction was stirred overnight at room temperature. The acetone was evaporated and the aqueous layer extracted with diethyl ether (3 x 50 mL). The aqueous layer was adjusted to pH=l using cone. HC1 and then extracted with ethyl acetate (3 x 75 mL). The ethyl acetate layers were pooled, dried using sodium sulfate, filtered and concentrated in vacuo to give product (,S)-l-((3,5- dichlorophenyl)sulfonyl)azetidine-2-carboxylic acid (67, 1.6 g, 100% yield) as a white solid. LC- MS: tR=2.06 min; m/z=309.8, 31 1.9. 1 NHMR (400 MHz, DMSO-d6) delta ppm 13.08 (br. s., 1 H) 8.06 (t, J=1.83 Hz, 1 H) 7.85 (d, J=1.96 Hz, 2 H) 4.63 (dd, J=9.54, 7.58 Hz, 1 H) 3.67 – 3.88 (m, 2 H) 2.29 – 2.42 (m, 1 H) 2.13 – 2.28 (m, 1 H).

The synthetic route of 2133-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SAINT LOUIS UNIVERSITY; WASHINGTON UNIVERSITY; RUMINSKI, Peter, G.; MEYERS, Marvin, L.; HEIER, Richard, F.; RETTIG, Michael, P.; DIPERSIO, John; (139 pag.)WO2018/85552; (2018); A1;,
Chiral Catalysts
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173035-10-4, 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of SIMes¡¤HCl (906mg, 2.64mmol) in THF (30mL) was added dropwise a 1.6M solution of n-butyl lithium in hexanes (1.65mL, 2.64mmol) at-78C with stirring. After 10min, the suspension was allowed to warm to room temperature for additional 10min. The mixture was cooled again to-78C and then treated with a cooled THF solution (-78C) of mesitylcopper (504mg including 0.09 equivalents of toluene, determined by 1H NMR, 2.64mmol) by means of a cannula. The reaction mixture was allowed to warm to room temperature and stirred for further 18h. The solvents were removed under reduced pressure. The resulting solid residue was dried for 2h and then extracted with toluene (50mL). The suspension was filtered through Kieselgur and the filter cake was washed with small portions of toluene (5mL). The resulting solution was concentrated under reduced pressure to 15mL and then stored at-18C for 18h while large colorless crystals were forming. The mother liquor was decanted from the crystals that were subsequently washed with cold toluene (5mL) and dried in vacuo for 15h. The mother liquor was combined with the washing solution, concentrated to 5mL and stored at-18C for about 3 weeks. From this solution a second crop of colorless crystals was isolated. Combined yield: 1.032g (2.11mmol, 80%). Anal. Calcd for C30H37N2Cu: C, 73.66; H, 7.62; N, 5.73. Found: C, 72.87; H, 7.91; N, 5.72. 1H NMR (500.13MHz, C6D6): delta 2.12 (s, 6H, p-CH3, NHC), 2.15 (s, 6H, o-CH3, CuMes), 2.18 (s, 12H, o-CH3, NHC), 2.26 (s, 3H, p-CH3, CuMes), 3.05 (s, 4H, CH2), 6.76 (s, 4H, CH, NHC), 6.86 (s, 2H, CH, CuMes). 13C NMR (125.77MHz, C6D6): delta 18.1 (o-CH3, NHC), 21.0 (p-CH3, NHC), 21.6 (p-CH3, CuMes), 28.0 (o-CH3, CuMes), 50.4 (CH2), 124.5 (CH, CuMes), 129.6 (CH, NHC), 132.7 (C, CuMes), 136.0, 136.2, 138.2 (3¡ÁC, Mes, NHC), 147.2 (C, CuMes), 163.7 (C, CuMes), 207.1 (C, CN2, NHC). MS (ESI in THF): m/z (rel. intensity)=675 (100) [(NHC)2Cu]+, 857 (34) [(NHC)2Cu2Mes]+; MS (ESI in CH3CN): m/z (rel. intensity)=764 (63) [(NHC)2Cu2(CN)]+, 675 (80) [(NHC)2Cu]+, 410 (42) [(NHC)Cu(CH3CN)]+, 397 (100) [(NHC)Cu(CO)]+, 369 (8) [(NHC)Cu]+, 307 (11) [(Mes)2(C3H4N2)+1]+. IR (KBr, cm-1): 3003, 2949, 2916, 2855, 2729, 2706, 1775, 1742, 1730, 1609, 1589, 1487, 1474, 1439, 1375, 1317, 1306, 1298, 1263, 1215, 1173, 1161, 1032, 1013, 951, 914, 883, 851, 839, 754, 741, 733, 721, 706, 689, 615, 602, 588, 573, 550, 532, 502, 482, 465, 419.

173035-10-4 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride 2734917, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Stollenz, Michael; Fischer, Stefan; Gehring, Henrike; Resch, Stefan G.; Dechert, Sebastian; Grosse, Christian; Meyer, Franc; Journal of Organometallic Chemistry; vol. 821; (2016); p. 106 – 111;,
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141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under an N2 atmosphere, the mixture of imidazolium salts 1 (1.1 mmol), benzoxazole or benzothiazole (2.0 mmol), PdCl2 (1.0 mmol) and K2CO3 (1.1 mmol) was stirred in anhydrous THF (10 mL) under reflux for 16 h. After cooling, filtration and evaporation,the residue was purified by preparative TLC on silica gelplates eluting with CH2Cl2 to afford the corresponding N-heterocyclic carbene-palladium(II) complexes 3a-d.

The synthetic route of 141556-45-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Tao; Xie, Huanping; Liu, Lantao; Zhao, Wen-Xian; Journal of Organometallic Chemistry; vol. 804; (2016); p. 73 – 79;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.

General procedure: Under an N2 atmosphere, the mixture of imidazolium salts 1 (1.1 mmol), benzoxazole or benzothiazole (2.0 mmol), PdCl2 (1.0 mmol) and K2CO3 (1.1 mmol) was stirred in anhydrous THF (10 mL) under reflux for 16 h. After cooling, filtration and evaporation,the residue was purified by preparative TLC on silica gelplates eluting with CH2Cl2 to afford the corresponding N-heterocyclic carbene-palladium(II) complexes 3a-d.

250285-32-6 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride 2734913, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Wang, Tao; Xie, Huanping; Liu, Lantao; Zhao, Wen-Xian; Journal of Organometallic Chemistry; vol. 804; (2016); p. 73 – 79;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33100-27-5,1,4,7,10,13-Pentaoxacyclopentadecane,as a common compound, the synthetic route is as follows.

Sodium hydride (60percent dispersion in mineral oil, 0.14 g) was added portionwise to a stirred solution of a portion (0.87 g) of the 3-hydroxypyrrolidine so obtained and 1,4,7,10,13-pentaoxacyclopentadecane (hereinafter 15-crown-5, 0.05 g) in DMF (10 ml). The mixture was stirred at ambient temperature for 15 minutes. A solution of methyl 4-toluenesulphonate (0-56 g) in THF (2 ml) was added dropwise and the mixture was stirred at ambient temperature for 2 hours. The mixture was partitioned between diethyl ether and water. The organic phase was dried (Na2 SO4) and evaporated. The residue was purified by column chromatography using increasingly polar mixtures of hexane and ethyl acetate as eluent. There was thus obtained 1-benzyl-3-(3,5-difluorophenyl)-3-methoxypyrrolidine (0.82 g, 90percent).

33100-27-5 1,4,7,10,13-Pentaoxacyclopentadecane 36336, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; Zeneca Limited; Zeneca Pharma S.A.; US5420298; (1995); A;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.94-91-7,N,N’-Bis(salicylidene)-1,2-propanediamine,as a common compound, the synthetic route is as follows.

A mixture of H2salipn (28.2mg, 0.100mmol) and [Ru(PPh3)3Cl2] (95.8mg, 0.100mmol) inTHF (30mL) was refluxed with stirring for 6 h, during which there was a color changefrom brown to dark green. The solvent was evaporated in vacuo, and the residue waswashed with diethyl ether (5mL 2) and hexane (5mL 2). Recrystallization fromCH2Cl2/hexane afforded black block crystals of 11.5CH2Cl2 in 7 days. Yield: 33.4mg,55.6% (based on Ru). IR (KBr disc, cm-1): 1594 (C=N), 1314 (Ar-O); MS (FAB): m/z 679[M], 644 [M – Cl], 417 [M – PPh3]. Anal. Calcd. for C35H31N2O2PClRu1.5(CH2Cl2) (%): C,54.41; H, 4.26; N, 3.48. Found: C, 54.47; H, 4.23; N, 3.50.

94-91-7 N,N’-Bis(salicylidene)-1,2-propanediamine 7210, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Ji, Jiao; Chen, Xin; Wang, Chang-Jiu; Jia, Ai-Quan; Zhang, Qian-Feng; Journal of Coordination Chemistry; vol. 72; 3; (2019); p. 480 – 490;,
Chiral Catalysts
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