Day: August 27, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

To anhydrous 1,4-dioxane (20 mL), [Pd(acac)2] (1 g, 3.3 mmol,1 equiv) and IMes*HCl (1.43 g, 3.7 mmol, 1.1 equiv) were added. The mixture was refluxed for 24 h. After the reaction, solvent was evaporated under vacuum. Diethyl ether was then added and stirred until no more solid was dissolved. The solution was filtered and diethyl ether was removed under vacuum. Yellow powder was washed with n-pentane and dried under vacuum. Yellow solids, yield:85%, 1H NMR (399.78 MHz, CDCl3) delta 7.08-6.94 (br,6H), 5.1 (s, 1H), 2.47-2.02 (br, 18H), 1.84-1.73 (6H), 13CNMR (100.53 MHz, CDCl3) delta 187.21, 183.16, 153.93,139.29, 137.60, 136.35, 135.01, 129.76, 128.90, 123.8,122.57, 99.68, 27.17, 25.61, 21.29, 18.93, 17.85.Synthesis of (IMes)Pd(tmhd)Cl. Yellow solids, yield:76%, 1H NMR (399.78 MHz, CDCl3) delta 7.09-6.96 (6H),5.50 (s, 1H), 2.40-2.31 (12H), 2.21-2.16 (6H), 1.04-0.95(18H), 13C NMR (100.53 MHz, CDCl3) delta 139.08, 136.64,135.40, 130.00, 128.74, 124.04, 90.65, 41.15-40.64, 29.07,28.51, 21.25, 18.99.

The synthetic route of 141556-45-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lee, Dong Jin; Kim, Myungwoong; Kim, Chan Kyung; Lee, Ik Mo; Bulletin of the Korean Chemical Society; vol. 40; 7; (2019); p. 710 – 718;,
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250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add ligand L8850mg (2.0mmol), copper powder 128mg (2.0mmol) in 50mL flask, water 30 mL, 80 ~ 90 in an oil bath, the reaction was stirred for 30 hours, the reaction mixture was cooled to room temperature, filtered, the filter cake was washed 3 times with water, the filter cake dissolved in acetonitrile and filtered to remove unreacted copper powder, the solvent was evaporated under reduced pressure to give 390 mg of colorless crystals, a yield of 40%.

As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

Reference£º
Patent; China Petroleum & Chemical Corporation Shanghai Research Institute of Petrochemical.; Liu, Bo; Jin, Zhaosheng; Lu, Jiangang; Li, Xianming; Zhou, Haichun; (13 pag.)CN105585584; (2016); A;,
Chiral Catalysts
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351498-10-7, 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 1Preparation of Intermediate Compound Int-lclnt-1a n – c Compound Int-la (733 mg, 1.33 mmol) was suspended in ethanol (10 mL) and the resulting suspension was heated to 80 C and allowed to stir for 5 minutes. Compound Int- lb (236 mg, 1.33 mmol) was then added and the resulting reaction was allowed to stir at 80 C for an additional 2 hours. The reaction was then cooled to room temperature using in an ice bath and the reaction mixture was filtered. The collected red solid was dried under vacuum to provide compound Int-lc (579 mg, 72%).

The synthetic route of 351498-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; GIRIJAVALLABHAN, Vinay; NJOROGE, F. George; BOGEN, Stephane; VERMA, Vishal; BENNETT, Frank; KEREKES, Angela; ARASAPPAN, Ashok; PISSARNITSKI, Dmitri; DANG, Qun; DAVIES, Ian; OLSEN, David, B.; STAMFORD, Andrew; VACCA, Joseph, P.; WO2012/142085; (2012); A1;,
Chiral Catalysts
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141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Palladium (II) complex with 1-methylimidazole ligands[PdCl2(1-methylimidazole)2] (0.5 mmol, 0.17 g), K2CO3 (1.5 mmol,0.21 g), MgSO4 (0.2 g, for drying), an appropriate imidazoliumchloride (0.65 mmol) and finally a mixture of solvents CH3CN:THF(8 ml: 5 ml) were placed in a round-bottom flask equipped with astirring bar. The flask was capped with a rubber septum. Themixture was heated in the oil bath for 24 h at 50 C in the air atmosphere.During that time, the color changed from yellow togreenish. After the reaction, the cooled down mixture was filtratedto remove inorganic salts. Then, the yellow solutionwas evaporatedunder vacuum and the resulting oily residue was dissolved in aminimum amount of acetone. Next, 10 ml of water was slowlyadded to the yellow solution and clouding of the mixture wasobserved. The mixture was left to evaporate acetone and to enablesedimentation of the formed precipitate. After that time, waterwith excess of the imidazolium chloride and 1-methylimidazolewas decanted. The obtained product was washed with the waterand dried under vacuum. The complexes 2f and 2 g were obtainedfrom the appropriate imidazole and the precipitated solids requiredadditional washing with ethyl alcohol and diethyl ether. One of theobtained complexes [PdCl2(IMes)(1-methylimidazole)] (2e) wasdescribed in the literature [7b].

141556-45-8 1,3-Dimesityl-1H-imidazol-3-ium chloride 2734211, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Sikorski; Zawartka; Trzeciak; Journal of Organometallic Chemistry; vol. 867; (2018); p. 323 – 332;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Prepared according a procedure of Mohr et al.21 To a soln of1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride (175 mg,0.513 mmol) in CH2Cl2 (10 mL) was added HgO (108 mg,0.514 mmol) and Me4NCl (56.4 mg, 0.51 mmol). After stirring at r.t. for 15 h, the soln was passed through Celite, the solvent was removed in vacuo, and the residue was washed with H2O (2 ¡Á 10 mL) and Et2O (2 ¡Á 10 mL) to give 14 as a colorless solid; yield: 240 mg (82%); mp 270 C (dec); Rf = 0.09 (CH2Cl2-MeOH, 10:1).

141556-45-8 1,3-Dimesityl-1H-imidazol-3-ium chloride 2734211, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Emsermann, Jens; Arduengo, Anthonyj.; Opatz, Till; Synthesis; vol. 45; 16; (2013); p. 2251 – 2264;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7181-87-5,1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide,as a common compound, the synthetic route is as follows.

50 mL round bottom flask that was capped with a rubber septum and containing a needle for ventilation and a glass pipette for addition of gaseous carbon dioxide, was charged with a clear colorless solution of 1,3-dimethylbenzimidazolium iodide (1b) (274.1 mg, 1 mmol) in deionized water (7 mL) (pH=6). Carbon dioxide was bubbled for 1 min followed by addition of hydrogen peroxide (65 muL (30% w/v), 0.75 mmol in 0.5 mL water, 1.5 equiv). Vigorous CO2 bubbling was maintained for 1 h under stirring during which time the solution turned yellow and then brown until the formation of a purple precipitate was detected. The mixture was filtered and washed with water (3¡Á2 mL) resulting in a clear colorless filtrate solution (pH=8). Water was removed by flushing air overnight over the surface of the solution then it was dried under high vacuum for 2 h to give a white solid. The residual solid was triturated and sonicated in acetone (3¡Á2 mL), which was then decanted off. Subsequent drying under vacuum afforded the desired product as a white powder (123 mg, 59% yield) Mp: 137-138 C. (dec.). (0410) 1H NMR (400 MHz, CD3OD): delta 7.96 (dd, J=6.2, 3.1 Hz, 2H, Ar-H), 7.74 (dd, J=6.3, 3.1 Hz, 2H, Ar-H), 4.15 (s, 6H, CH3). The N2CH and HCO3 protons could not be observed due to their rapid exchange with the deuterated solvent on the NMR time scale. 13C (1H) NMR (100 MHz, CD3OD): delta 161.38 (s, HCO3-), 143.94 (s, N2CH), 133.54 (s, Cq), 128.18 (s, CAr), 114.15 (s, CAr), 33.65 (s, CH3). (0411) ATR-IR: strong peaks for CO2 asym. str. at 1626 cm-1 and sym. str. at 1367 cm-1. (0412) Anal. Calc. for C10H12N2O3: C, 57.68; H, 5.81; N, 13.45. Found: C, 57.72; H, 5.75; N, 13.03. HRESI-MS (m/z) for C9H11N2+ [M-HCO3]+: 147.0913, Calc.: 147.0917.

The synthetic route of 7181-87-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Queen’s University at Kingston; Crudden, Cathleen M.; Horton, J. Hugh; Narouz, Mina Raafat Ryad; Unsworth, Phillip; Li, Zhijun; Nazemi, Ali; Padmos, Joseph Daniel; Eisenberger, Patrick; Zamora, Matthew Thomas; MacLean, Michael William Angus; (114 pag.)US2019/169132; (2019); A1;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.351498-10-7,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),as a common compound, the synthetic route is as follows.

Preparation of Cobalt(ll) Complex used in Step 2: A 50 mL flask was charged with lambda/,lambda/-bis(3,5-di-tert-butylsalicylidene)-1 , 1 ,2,2- tetramethylethenediamine (0.4302 g, 0.78 mmol, 1.0 equiv), EtOH (17 mL), and Co(OAc)2 (0.1385 g, 0.78 mmol, 1.0 equiv). The mixture was degassed and then heated to reflux under nitrogen for 3 h, cooled to room temperature. The precipitate was filtered and the purple solid was washed with EtOH (10 mL) and dried under high vacuum to give 0.3533 g (75%) of the cobalt(ll) complex.

351498-10-7 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) 135404188, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; WO2009/88997; (2009); A1;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33100-27-5,1,4,7,10,13-Pentaoxacyclopentadecane,as a common compound, the synthetic route is as follows.

To the sodium salt of 2-nitroimidazole prepared above was added acetonitrile (50 ml), 15-crown-5-ether (3.5 ml, 14.3 mmol) and 4-bromo-2-methyl-2-butene (2 ml; 17.4 mmol). The mixture was stirred at RT for ca 16 h. and then the solvent was removed to leave a crude semi-solid which was purified by column chromatography on silica. The intermediate product, 1-(3-methyl-2-butenyl)-2-nitroimidazole (80percent yield) was eluted using a mixture of petroleum ether (40-60)/ethyl acetate (ratio 4:1 respectively).

As the paragraph descriping shows that 33100-27-5 is playing an increasingly important role.

Reference£º
Patent; Amersham International plc; US5993774; (1999); A;,
Chiral Catalysts
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14098-24-9, Benzo-18-crown 6-Ether is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

For example, the co-crystal compound of the present invention can be prepared by an anti-solvent method, and the specific implementation is described below. With reference to FIG. 2 for a schematic view of preparing a co-crystal compound of the present invention, the same mole of ammonium nitrate (NH4NO3) and benzo-18-crown-6-ether (C16H24O6) are prepared and added into a glass reactor 200. In this preferred embodiment, the quantities of both ammonium nitrate and benzo-18-crown-6-ether are equal to 0.048 mole, and then a 25 ml pipette 210 is used to titrate approximately 31 ml of methanol (MeOH) in the glass reactor 200. A water bath takes place in the glass reactor 200 in a water tank at 25 C., and a blender 220 is provided for blending at 250 rpm for two hours., and finally the 25 ml pipette 210 is used for titrate methyl tertiary butyl ether into the glass reactor 200 slowly. Now, the solution in the glass reactor 200 becomes turbid gradually, and then we can wait for the formation of the co-crystal compound of the present invention.

14098-24-9 Benzo-18-crown 6-Ether 585779, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; NATIONAL CENTRAL UNIVERSITY; Tu, Lee; Chen, Jeng-Wei; US2013/102797; (2013); A1;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.137848-28-3,(R)-2′-amino-[1,1′-binaphthalen]-2-ol,as a common compound, the synthetic route is as follows.

General procedure: Modified method [67]. 3-tert-Butylsalicylaldehyde (1.78 g,10.0 mmol) was mixed with (R)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g, 10.0 mmol) in dry toluene (50 mL). A few 4 A molecular sieves were added, and the solution was warmed up to 70 Cand kept for two days at this temperature. The solution was filtered and the solvent was removed under reduced pressure. The residue was purified by column chromatography (n-hexane/ethyl acetate= 5:1) to give 2H2 as a yellow solid. Yield: 4.09 g (92%). M.p.: 86-88 C. 1H NMR (C6D6): d 13.28 (s, 1H, OH), 8.31 (s, 1H, CHN), 7.80 (m, 4H, aryl), 7.62 (d, J = 8.4 Hz, 1H, aryl), 7.38 (d, J = 8.9 Hz,1H, aryl), 7.22 (m, 5H, aryl), 7.12 (m, 2H, aryl), 6.87 (d, J = 7.5 Hz,1H, aryl), 6.71 (t, J = 7.6 Hz, 1H, aryl), 4.52 (br s, 1H, OH), 1.45 (s,9H, CH3). These spectroscopic data were in agreement with those reported in the literature [67].

The synthetic route of 137848-28-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Liang; Zhao, Ning; Wang, Qiuwen; Hou, Guohua; Song, Haibin; Zi, Guofu; Inorganica Chimica Acta; vol. 402; (2013); p. 140 – 155;,
Chiral Catalysts
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