Day: August 28, 2020

As a common heterocyclic compound, it belong chiral-catalyst compound,1,4,7,10,13-Pentaoxacyclopentadecane,33100-27-5,Molecular formula: C10H20O5,mainly used in chemical industry, its synthesis route is as follows.,33100-27-5

General procedure: A solution of (2 mmol, 0.4 ml) of 15-crown-5 in (10 ml) of absolute ethanol was added to a solution of (1 mmol, 0.933 gm Pr-picrate), (0.936 gm Nd-picrate) and (0.900 gm Dy-picrate) in (10 ml) of absolute ethanol and refluxed at (50 ? 60 oC) for (1 hr.). The solution was concentrated at (40 ? 50 oC) to a very small volume (till the formation of a precipitate), usually a gummy precipitate forms which was treated with (40 ? 60 oC) petroleum ether until all the gummy precipitate was converted to a fine yellow ? orange powder. The precipitate was collected and stored in a desicator for complete dryness. These complexes were also prepared by another method, by stirring a solution of 15-crown-5 with a solution of lanthanide picrate for (24 ? 48 hrs.). The gummy precipitates were treated with petroleum ether. The yields were (92 ? 96percent)24.

With the synthetic route has been constantly updated, we look forward to future research findings about 1,4,7,10,13-Pentaoxacyclopentadecane,belong chiral-catalyst compound

Reference£º
Article; Al-Amery, Mohammed H. A.; Al-Abdaly, B. Ibrahim; Albayaty, M. Kahtan; Oriental Journal of Chemistry; vol. 32; 2; (2016); p. 1025 – 1048;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belong chiral-catalyst compound,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),351498-10-7,Molecular formula: C36H56N2O2,mainly used in chemical industry, its synthesis route is as follows.,351498-10-7

EXAMPLE 1Preparation of Intermediate Compound Int-lclnt-1a n – c Compound Int-la (733 mg, 1.33 mmol) was suspended in ethanol (10 mL) and the resulting suspension was heated to 80 C and allowed to stir for 5 minutes. Compound Int- lb (236 mg, 1.33 mmol) was then added and the resulting reaction was allowed to stir at 80 C for an additional 2 hours. The reaction was then cooled to room temperature using in an ice bath and the reaction mixture was filtered. The collected red solid was dried under vacuum to provide compound Int-lc (579 mg, 72%).

With the synthetic route has been constantly updated, we look forward to future research findings about 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),belong chiral-catalyst compound

Reference£º
Patent; MERCK SHARP & DOHME CORP.; GIRIJAVALLABHAN, Vinay; NJOROGE, F. George; BOGEN, Stephane; VERMA, Vishal; BENNETT, Frank; KEREKES, Angela; ARASAPPAN, Ashok; PISSARNITSKI, Dmitri; DANG, Qun; DAVIES, Ian; OLSEN, David, B.; STAMFORD, Andrew; VACCA, Joseph, P.; WO2012/142085; (2012); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belong chiral-catalyst compound,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),351498-10-7,Molecular formula: C36H56N2O2,mainly used in chemical industry, its synthesis route is as follows.,351498-10-7

Compound Int-1a (733 mg, 1.33 mmol) was suspended in ethanol (10 mL) and the resulting suspension was heated to 80 C and allowed to stir for 5 minutes. Compound Int- 1b (236 mg, 1.33 mmol) was then added and the resulting reaction was allowed to stir at 80 C for an additional 2 hours. The reaction was then cooled to room temperature using in an ice bath and the reaction mixture was filtered. The collected red solid was dried under vacuum to provide compound Int-1c (579 mg, 72%).

With the synthetic route has been constantly updated, we look forward to future research findings about 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),belong chiral-catalyst compound

Reference£º
Patent; MERCK SHARP & DOHME CORP.; GIRIJAVALLABHAN, Vinay; BOGEN, Stephane; TRUONG, Quang, T.; CHEN, Ping; KEREKES, Angela; BENNETT, Frank; ESPOSITE, Sara; HONG, Qingmei; DAVIES, Ian; WO2014/62596; (2014); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO415,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

For example, the co-crystal compound of the present invention can be prepared by an anti-solvent method, and the specific implementation is described below. With reference to FIG. 2 for a schematic view of preparing a co-crystal compound of the present invention, the same mole of ammonium nitrate (NH4NO3) and benzo-18-crown-6-ether (C16H24O6) are prepared and added into a glass reactor 200. In this preferred embodiment, the quantities of both ammonium nitrate and benzo-18-crown-6-ether are equal to 0.048 mole, and then a 25 ml pipette 210 is used to titrate approximately 31 ml of methanol (MeOH) in the glass reactor 200. A water bath takes place in the glass reactor 200 in a water tank at 25 C., and a blender 220 is provided for blending at 250 rpm for two hours., and finally the 25 ml pipette 210 is used for titrate methyl tertiary butyl ether into the glass reactor 200 slowly. Now, the solution in the glass reactor 200 becomes turbid gradually, and then we can wait for the formation of the co-crystal compound of the present invention.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound

Reference£º
Patent; NATIONAL CENTRAL UNIVERSITY; Tu, Lee; Chen, Jeng-Wei; US2013/102797; (2013); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO311,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

General procedure: A modification of the previously reported procedure23 was used. Commercially available Eaton’s reagent (ca. 8 ml that corresponds to 6.28 mmol of phosphorus(V) oxide) and acetic acid (0.20 ml, 3.45 mmol) were mixed at room temperature. Then naphtho-15-crown-5 ether (1 g, 3.14 mmol) was added. The reaction mixture was stirred at room temperature for ca. 6 h and then poured into water. The suspension was extracted with dichloromethane and the combined organic phases were washed with water. Removal of the dried (MgSO4) solvent gave a dark brown oil, which upon repeated extractions with hot heptane, afforded the product as an off-white solid (1.02 g, 90%), mp 126-129 C.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound

Reference£º
Article; Paramonov, Sergey V.; Lokshin, Vladimir; Smolentsev, Artem B.; Glebov, Evgeni M.; Korolev, Valeri V.; Basok, Stepan S.; Lysenko, Konstantin A.; Delbaere, Stephanie; Fedorova, Olga A.; Tetrahedron; vol. 68; 38; (2012); p. 7873 – 7883;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO35,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

Concentrated nitric acid (0.25 ml) was added to a stirring solution of benzo-18-crown-6 (12) (0.25 g, 0.81 mmol) in dichloromethane (15 ml). The solution was allowed to stir at room temperature for 24 hours. The organic layer was washed with water (3 x 30 ml), dried over sodium sulfate, filtered and the solvent removed under reduced pressure. The isolated oily product solidified upon standing to give 0.28 g of (13) as a yellow crystalline solid (0.78 mmol, 96 % yield). 1H n. m. r. of the crude indicated the presence of product and also dichloromethane. The product was allowed to dry for another 24 hours before its employment in subsequent reactions. Melting point: 82-83 C (Literature mp: 80-81 C)31. Decompostion at: 312 C. 1H n. m. r. (300 MHz, CDCl3): delta 7.88 (dd, 1H, J 8.9 Hz, 2.6 Hz, Ar-H); 7.74 (d, 1 H, J 2.6 Hz, Ar-H); 6.89 (d, 1 H, J 8.9 Hz, Ar-H); 4.24 (m, 4H, OCH2); 3.95 (m, 4H, OCH2); 3.77 (m, 4H, OCH2); 3.72 (m, 4H, OCH2); 3.68 (s, 4H, OCH2). 13C n. m. r. (75 MHz, CDCl3): delta 154.3, (C4); 148.4, (C2); 141.3, (C1); 117.9, (C5); 111.2, (C6); 108.1, (C3); 70.99, (OCH2); 70.98, (OCH2); 70.8, (OCH2); 70.7, (OCH2); 70.60, (OCH2); 70. 57, (OCH2); 69.23, (OCH2); 69.17, (OCH2); 69.1, (OCH2). IR (Nujol): 1587, m; 1520, s; 1464, s; 1338, s; 1276, s; 1128, s; 864, w. Mass spectrum (ESI,+ve): m/z 358.1 [M]+; 381.1 [M + Na]+.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound

Reference£º
Patent; Monash University; WO2003/99762; (2003); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belong chiral-catalyst compound,Benzo-18-crown 6-Ether,14098-24-9,Molecular formula: C16H24O6,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound

Reference£º
Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belong chiral-catalyst compound,Benzo-18-crown 6-Ether,14098-24-9,Molecular formula: C16H24O6,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

General procedure: 4.2.1. Method A. molecular clip 2 was obtained in 50% yield as described6b Method B. A mixture of bisether 8 (1 g, 2.65 mmol) and corresponding benzocrown ether (5.42 mmol) in PPA (30 g) was stirred vigorously at 80-85 for 30 min. A deep purple color was formed in 5 min. To the cooled reaction mixture was added water (150 mL) and product was extracted with CHCl3 (3¡Á50 mL). The organic layer was washed with water until neutral (?3¡Á50 mL) and subjected to azeotropic drying. The solvent was removed at reduced pressure and the residue was dissolved in a mixture of CHCl3/MeOH (50:1, 100 mL) and filtered through SiO2 (~30 mL). The solvent was removed at reduced pressure and the crude product was purified as described below. Method C. The procedure is similar to Method B, with exception that tetraol 9 (1.1 g, 2.65 mmol) was used instead bisether 8. Method D. A suspension of NaH (0.288 g, 12 mmol) in DMSO (26 mL) was heated with stirring at 70 for 30 min. The resulting mixture was cooled to room temperature and a solution of 11 (0.78 g, 2.65 mmol) in DMSO (40 mL) was added. Stirring was continued for 20 min and then solution of 10 (5.92 g, 5.83 mmol) in DMSO (40 mL) was added dropwise over 5 min and the resulting mixture was stirred at room temperature for 24 h. The mixture was poured into ice water (400 mL) and acidified with HCl to pH~2. The resulting solid was filtered off, washed with water (3¡Á50 mL). The crude product was purified as described below.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound

Reference£º
Article; Bogaschenko, Tatiana Yu.; Lyapunov, Alexander Yu.; Kikot’, Leonid S.; Mazepa, Alexander V.; Botoshansky, Mark M.; Fonari, Marina S.; Kirichenko, Tatiana I.; Tetrahedron; vol. 68; 24; (2012); p. 4757 – 4764;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belong chiral-catalyst compound,Benzo-18-crown 6-Ether,14098-24-9,Molecular formula: C16H24O6,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound

Reference£º
Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO310,mainly used in chemical industry, its synthesis route is as follows.,94-91-7

General procedure: Uranyl acetate dehydrate (1 mmol) and synthesized Schiff base (1 mmol) (1:1 ratio) were mixed in methanol (25 ml). The mixture was refluxed for 3 h and then allowed to cool to room temperature. An orange (red) precipitate was filtered off, washed with methanol, and dried at room temperature (Scheme 1).

With the synthetic route has been constantly updated, we look forward to future research findings about N,N’-Bis(salicylidene)-1,2-propanediamine,belong chiral-catalyst compound

Reference£º
Article; Asadi, Zahra; Shorkaei, Mohammad Ranjkesh; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 105; (2013); p. 344 – 351;,
Chiral Catalysts
Chiral catalysts – SlideShare