Day: September 2, 2020

The chiral-catalyst compound, cas is 33100-27-5 name is 1,4,7,10,13-Pentaoxacyclopentadecane, mainly used in chemical industry, its synthesis route is as follows.,33100-27-5

EXAMPLE 8 Synthesis of 4-(4-fluorobenzylidene)piperidine hydrochloride To a stirred suspension of 13.20 g of 60percent sodium hydride (in oil) containing 1.65 g of 15-crown-5 ether in 650 ml of tetrahydrofuran were added dropwise a solution of 59.78 g of N-t-butoxycarbonylpiperidone and 81.25 g of diethyl 4-fluorobenzylphosphonate in 150 ml of tetrahydrofuran under ice-cooling over 20 minutes. After stirring at room temperature for a day, a saturated aqueous sodium bicarbonate solution was added cautiously, followed by extracting with ethyl acetate. The extract was washed with a saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium chloride solution, successively, and dried over anhydrous sodium sulfate, followed by removal of the drying agent by filtration. The filtrate was concentrated under reduced pressure and purified by a flash column chromatography (silica gel: Wakogel C200 (manufactured by Wako Pure Chemicals), eluent; hexane-ethyl acetate =20:1) to give 55.23 g of N-t-butoxycarbonyl-4-(4-fluorobenzylidene)piperidine as an oil, which was then crystallized by allowing to stand at room temperature overnight. m.p. 69-70¡ãC. To 55.00 g of N-t-butoxycarbonyl-4-(4-fluorobenzylidene)piperidine was added 475 ml of an ice-cooled solution of 4 N hydrogen chloride in dioxane, followed by stirring at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure, and the resulting crystals were recrystallized from isopropanol to give 40.72 g of 4-(4-fluorobenzylidene)piperidine hydrochloride. m.p. 184-185.5¡ã C.

As the rapid development of chemical substances, we look forward to future research findings about 33100-27-5

Reference£º
Patent; Taisho Pharmaceutical Co., Ltd.; Nihon Nohyaku Co. Ltd.; US6291467; (2001); B1;,
Chiral Catalysts
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The chiral-catalyst compound, cas is 141556-45-8 name is 1,3-Dimesityl-1H-imidazol-3-ium chloride, mainly used in chemical industry, its synthesis route is as follows.,141556-45-8

Tris [4- (pyridin-4-yl) phenyl] amine compound (47.6 mg, 0.10 mmol)1,3-bis (2,4,6-trimethylphenyl) imidazole chloride(IMes. HCl) (102.1 mg, 0.30 mmol),PdCl2 (53.2 mg, 0.30 mmol)And potassium carbonate (41.5 mg, 0.30 mmol) were added to a 25 mL single neck flask,Tetrahydrofuran (5 mL) was then added,The reaction was stirred at 75 C for 14 h under argon atmosphere.Stop the reaction,Cool to room temperature,concentrate,Thin layer chromatography to give compound II,Yield 50%.

As the rapid development of chemical substances, we look forward to future research findings about 141556-45-8

Reference£º
Patent; Shangqiu Normal University; Wang Tao; Xu Kai; Liu Lantao; Zhao Wenxian; Liu Shuang; Li Feng; Meng Tuanjie; Xie Huanping; (12 pag.)CN105131044; (2017); B;,
Chiral Catalysts
Chiral catalysts – SlideShare

The chiral-catalyst compound, cas is 33100-27-5 name is 1,4,7,10,13-Pentaoxacyclopentadecane, mainly used in chemical industry, its synthesis route is as follows.,33100-27-5

General procedure: A solution of (2 mmol, 0.4 ml) of 15-crown-5 in (10 ml) of absolute ethanol was added to a solution of (1 mmol, 0.933 gm Pr-picrate), (0.936 gm Nd-picrate) and (0.900 gm Dy-picrate) in (10 ml) of absolute ethanol and refluxed at (50 ? 60 oC) for (1 hr.). The solution was concentrated at (40 ? 50 oC) to a very small volume (till the formation of a precipitate), usually a gummy precipitate forms which was treated with (40 ? 60 oC) petroleum ether until all the gummy precipitate was converted to a fine yellow ? orange powder. The precipitate was collected and stored in a desicator for complete dryness. These complexes were also prepared by another method, by stirring a solution of 15-crown-5 with a solution of lanthanide picrate for (24 ? 48 hrs.). The gummy precipitates were treated with petroleum ether. The yields were (92 ? 96percent)24.

As the rapid development of chemical substances, we look forward to future research findings about 33100-27-5

Reference£º
Article; Al-Amery, Mohammed H. A.; Al-Abdaly, B. Ibrahim; Albayaty, M. Kahtan; Oriental Journal of Chemistry; vol. 32; 2; (2016); p. 1025 – 1048;,
Chiral Catalysts
Chiral catalysts – SlideShare

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In air, to a Schlenk tube that closed with a screw cap fitted with a septum and was equipped with a magnetic stir bar were added in turn NHC¡¤HCl (1.1 mmol, 468 mg), PdCl2 (1.0 mmol, 177 mg), Cs2CO3 (5 mmol, 1.63 g), and 2-nicotinic acid (1.1 mmol, 136 mg). The tube was then caped with a rubber septum and evacuated and backfilled with argon. This sequence was repeated three times. 1,4-Dioxane (10 mL) was injected through the septum. The mixture was then stirred at a pre-heated oil bath (80 C) for 20 h. The reaction mixture was cooled to room temperature and CH2Cl2 (25 mL) added. After filtration via a short pad of celite, the filtrate was condensed under vacuum and the residue was purified by flash chromatography on silica gel to provide the desired 1 and 2., 250285-32-6

The synthetic route of 250285-32-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Yan-Jing; Zhang, Jin-Ling; Li, Xiao-Jian; Geng, Yu; Xu, Xiao-Hua; Jin, Zhong; Journal of Organometallic Chemistry; vol. 737; (2013); p. 12 – 20;,
Chiral Catalysts
Chiral catalysts – SlideShare

141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A 20 mL vial was charged with the NHC¡¤HCl (300 mg, 1 equiv.) and the zinc salt (1 equiv.). Tetrahydrofuran (5 mL) was added, the vial was sealed with a screw-cap and the reaction was stirred at 60C for two hours. The mixture was allowed to reach room temperature and the solvent was removed under reduced pressure toafford the desired product., 141556-45-8

141556-45-8 1,3-Dimesityl-1H-imidazol-3-ium chloride 2734211, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Santoro, Orlando; Nahra, Fady; Cordes, David B.; Slawin, Alexandra M.Z.; Nolan, Steven P.; Cazin, Catherine S.J.; Journal of Molecular Catalysis A: Chemical; vol. 423; (2016); p. 85 – 91;,
Chiral Catalysts
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The chiral-catalyst compound, cas is 22795-99-9 name is (S)-(1-Ethylpyrrolidin-2-yl)methanamine, mainly used in chemical industry, its synthesis route is as follows.,22795-99-9

25.9 g of ethyl 2-methoxy-5-sulfamoylbenzoate,(S) 1-ethyl-2-aminomethyltetrahydropyrrolidine 15g and isopropanol 20g were added to the reaction flask,The reaction was carried out at 80 ¡ã C for 36 hours, the reaction was completed, and 10 g of ethanol was added.Stir under reflux for 10 minutes, cool to 5 ¡ã C and stir for 1 hour.It was filtered, washed with ethanol and dried at 65 ¡ãC. The yield was 90.3percent and the purity was 99.1percent.

As the rapid development of chemical substances, we look forward to future research findings about 22795-99-9

Reference£º
Patent; Jiangsu Tianshili Diyi Pharmaceutical Co., Ltd.; Liu Jinping; Liu Wenzheng; Zhu Zhanyuan; Yang Guojun; (5 pag.)CN103804265; (2018); B;,
Chiral Catalysts
Chiral catalysts – SlideShare

The chiral-catalyst compound, cas is 250285-32-6 name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, mainly used in chemical industry, its synthesis route is as follows.,250285-32-6

General procedure: Under a N2 atmosphere, a mixture of imidazolium salts 1(0.225 mmol), PdCl2 (0.15 mmol), K2CO3 (0.45 mmol) and picolinicacid 2 (0.15 mmol) was stirred in anhydrous THF (2.0 mL) underreux for 12 h. Then the solvent was removed under reducedpressure, and the residue was puried by ash column chroma-tography (SiO2) to give complexes 3 as yellow solids. 4.2.1.1. Compound 3a. yellow solid. m.p. 248C (decomposed).1HNMR (500 MHz, CDCl3, TMS) d 8.55 (d, J 5.5 Hz, 1H), 7.83e7.77 (m,2H), 7.49 (t, J 7.5 Hz, 2H), 7.34 (d, J 7.5 Hz, 4H), 7.31e7.28 (m,1H),7.17 (s, 2H), 2.95 (hept, J 7.0 Hz, 4H), 1.42 (d, J 7.0 Hz, 12H), 1.14(d, J 7.0 Hz, 12H).13C NMR (125 MHz, CDCl3) d 172.7, 157.4, 151.3,146.8, 146.5, 139.1, 134.5, 130.4, 126.6, 126.2, 125.1, 124.0, 28.6, 26.2,22.9. IR (neat) n 2964, 1668, 1600, 1458, 1408, 1337, 1291, 1047, 944,800, 771, 755, 713 cm1. HRMS (ESI) calcd for C33H41ClN3O2Pd[MH]: 654.1920; found: 654.1917. Anal. calcd forC33H40ClN3O2Pd: C, 60.47%; H, 6.18%; N, 6.44%; found: C, 60.62%; H,6.11%; N, 6.31%.

With the rapid development of chemical substances, we look forward to future research findings about 250285-32-6

Reference£º
Article; Zhang, Zhi-Mao; Gao, Yu-Jue; Lu, Jian-Mei; Tetrahedron; vol. 73; 52; (2017); p. 7308 – 7314;,
Chiral Catalysts
Chiral catalysts – SlideShare

141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Ag2O (0.5 mmol) was added to a solution of the imidazolium ligand (1mmol) in CH2Cl2. The suspension became clear after stirring 3 h at room temperature. Then a solution of Me2SAuCl (1mmol) in CH2Cl2 was added dropwise. The reaction mixture was stirred for another 4 h. Then the solution was filtered through Celite and the solvent evaporated to leave a volume of ca. 3 ml. The addition of hexane led to the precipitation of a white solid., 141556-45-8

The synthetic route of 141556-45-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Perez-Galan, Patricia; Waldmann, Herbert; Kumar, Kamal; Tetrahedron; vol. 72; 26; (2016); p. 3647 – 3652;,
Chiral Catalysts
Chiral catalysts – SlideShare

The chiral-catalyst compound, cas is 14098-24-9 name is Benzo-18-crown 6-Ether, mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

A mixture of chloroform (50 ml) and acetic acid (50 ml) were charged in 250 ml round bottom flask. The monobenzo 18-crown-6 ether was added in to the mixture and stirred well. Afterword 8.5 ml nitric acid (70%) slowly dropwise added over a period of 30 min and stirring was continued at RT for additional 24 hr. Then the mixture was neutralized with aqueous Na2CO3 and the reaction product in to aqueous layer extract with chloroform (70 ml x 3). The combined chloroform layer dried by Na2SO4 and evaporated on rotary evaporator observed a yellow crude solid. Crude solid was recrystallized in ethanol to furnish a pure nitro product. Yield: 77%; m.p. 69-71C (Lit.70-72C).

With the rapid development of chemical substances, we look forward to future research findings about 14098-24-9

Reference£º
Article; Patil, Dayanand R.; Chandam, Dattatraya R.; Mulik, Abhijeet G.; Jagdale, Suryabala D.; Patil, Prasad P.; Deshmukh, Madhukar B.; Synthetic Communications; vol. 45; 16; (2015); p. 1902 – 1911;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14098-24-9,Benzo-18-crown 6-Ether,as a common compound, the synthetic route is as follows.

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product., 14098-24-9

14098-24-9 Benzo-18-crown 6-Ether 585779, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare