Day: September 11, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22795-99-9,(S)-(1-Ethylpyrrolidin-2-yl)methanamine,as a common compound, the synthetic route is as follows.

General procedure: Benzoic acid derivatives (1 mmol) and heterogeneous catalyst (10 mg) were mixed for 5 min in 1 mL of anhydrous toluene. Then, the amine (1.2 mmol) was added and the mixture was reacted under ultrasound for about 15-60 min at room temperature. After completion of the reaction (monitored by TLC), the catalyst was separated through filtration and the solvent was removed in vacuo. The obtained residue was dissolved in chloroform (10 ml) and washed with 10% NaHCO3 (10 ml) and HCl (1 M, 10 ml). The organic layer was extracted and dried over Na2SO4 and concentrated under reduced pressure to afford the amide, which was purified by recrystallization or column chromatography., 22795-99-9

As the paragraph descriping shows that 22795-99-9 is playing an increasingly important role.

Reference£º
Article; Ahmadi, Masoumeh; Moradi, Leila; Sadeghzadeh, Masoud; Research on Chemical Intermediates; vol. 44; 12; (2018); p. 7873 – 7889;,
Chiral Catalysts
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6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol), cas is 351498-10-7, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,351498-10-7

Cobalt catalyst 1 was prepared as follows: A 50 mL flask was charged with lambda/,/V’-bis(3,5-di-fert-butylsalicylidene)-1 ,1 ,2,2-tetramethylethenediamine (0.4302 g, 0.78 mmol, 1.0 equiv), EtOH (17 mL), and Co(OAc)2 (0.1385 g, 0.78 mmol, 1.0 equiv). The mixture was degassed and then heated to reflux under nitrogen for 3 h, cooled to room temperature. The precipitate was filtered and the purple solid was washed with EtOH (10 mL) and dried under high vacuum to give 0.3533 g (75%) of the cobalt(l I) complex. LC-MS Method 2 tR = 1.921 min, m/z = 440.1 ; 1H NMR (CD3OD) delta=1.25 (s, 3H), 1.49 (s, 3H), 2.04 (d, 3H), 2.34 (m, 2H), 2.38 (m, 1 H), 2.40 (m, 2H), 3.02 (m, 1H), 5.67 (m, 1 H), 6.97 (m, 2H), 7.26 (m, 3H), 7.38 (m, 4H).

As the rapid development of chemical substances, we look forward to future research findings about 351498-10-7

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; WO2009/61498; (2009); A1;,
Chiral Catalysts
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1,3-Dimesityl-1H-imidazol-3-ium chloride, cas is 141556-45-8, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,141556-45-8

General procedure: Under an N2 atmosphere, the mixture of imidazolium salts 1 (1.1 mmol), benzoxazole or benzothiazole (2.0 mmol), PdCl2 (1.0 mmol) and K2CO3 (1.1 mmol) was stirred in anhydrous THF (10 mL) under reflux for 16 h. After cooling, filtration and evaporation,the residue was purified by preparative TLC on silica gelplates eluting with CH2Cl2 to afford the corresponding N-heterocyclic carbene-palladium(II) complexes 3a-d.

As the rapid development of chemical substances, we look forward to future research findings about 141556-45-8

Reference£º
Article; Wang, Tao; Xie, Huanping; Liu, Lantao; Zhao, Wen-Xian; Journal of Organometallic Chemistry; vol. 804; (2016); p. 73 – 79;,
Chiral Catalysts
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7181-87-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7181-87-5,1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide,as a common compound, the synthetic route is as follows.

Additions: [0291] 0.6 gram of a Karstedt solution containing 16.2% platinum, i.e. 0.5 mmol of platinum, [0292] 137 mg of N,N-dimethylbenzimidazolium iodide, i.e. 0.5 mmol (1. 0 equiv.) (A,B,T3,T4=benzyl; T1T2=methyl), [0293] 112 mg of potassium tert-butoxide, i.e. 1 mmol (2 equiv.) [0294] 20 ml of dry THF. [0295] The solution of the Karstedt complex and the benzimidazolium salt are placed in the round-bottomed flask and then diluted in 20 ml of THF. The potassium tert-butoxide is added at room temperature and the mixture is stirred for 36 hours in the absence of light. The reaction medium is diluted in dichloromethane and then washed with water. The solvent is evaporated off and the oil obtained is rapidly filtered through silica gel (eluent: CH2Cl2). After evaporating off the solvent, the solid obtained is rinsed with two milliliters of hexamethyldisiloxane. 173 mg (66% yield) of an analytically pure white solid are obtained.

7181-87-5 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide 11821793, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Buisine, Olivier; Marko, Istvan; Sterin, Sebastien; US2004/198996; (2004); A1;,
Chiral Catalysts
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(S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,22795-99-9

153 g of 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid and 789 g of acetone were placed in a flask fitted with a stir bar, a thermocouple and a nitrogen line. The solution was cooled to -8 C., and then 70.4 g of ethyl chloroformate was added to the flask. An addition funnel was fitted to the flask and 79.3 g of 4-methyl morpholine was added drop wise, maintaining the temperature below 0 C. The mixture was agitated at -8 C. and then 55 g of (S)-(1-ethylpyrrolidin-2-yl)methanamine was added drop wise. The mixture was agitated at 0 C. for 1 hour, warmed to ambient temperature and then further agitated at ambient temperature to provide S-4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide starting material. The reaction was then concentrated to minimum volume and 822 g of water, followed by 311 g of ethyl acetate, was added. The mixture was agitated and the organic layer removed. The solution was heated to 35 C. and 755 g of ethyl acetate and 326 g of 40 wt % potassium carbonate (aq) were added. The mixture was agitated, the phases allowed to separate, and the aqueous layer removed. Then 296 g of water of water was added, the mixture agitated, the phases allowed to separate and the aqueous layer removed. 302 g of water was added, the mixture agitated, the phases allowed to separate and the aqueous layer removed. The organic layer was transferred to a flask with a mechanical stirrer, a thermocouple and a nitrogen line. The organic layer was concentrated to dryness and 531 g of ethyl acetate was added. After agitation, the solution was concentrated to 400 mL. Then 305 g of ethyl acetate was added and the solution was concentrated to 400 mL and was 0.35 wt % water by Karl Fischer titration. The solution was then cooled to 30 C. and seeded with 300 mg of S-4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide and a slurry formed. The solution was then cooled to 20 C. and agitated, and 495 g of methyl t-butyl ether was added. The slurry was then filtered, washed with 3:1 wt/wt methyl t-butyl ether:ethyl acetate and dried. 160.7 g of S-4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide was obtained as a crystalline solid, representing a yield of about 74%.

As the rapid development of chemical substances, we look forward to future research findings about 22795-99-9

Reference£º
Patent; Sunovion Pharmaceuticals Inc.; Hopkins, Seth Cabot; Koblan, Kenneth Stephen; Snoonian, John R.; Wilkinson, Harold Scott; (95 pag.)US2019/167635; (2019); A1;,
Chiral Catalysts
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(R)-2′-amino-[1,1′-binaphthalen]-2-ol, cas is 137848-28-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,137848-28-3

General procedure: To a mixture of 3,4-dimethoxy-3-cyclobutene-1 ,2-dione (Ia) (0.2 mmol) in MeOH (0.25- 1 mL) the amine 2a-m was firstly added at room temperature. After the correspondingreaction time (ti) (see Table I), the amine 4a-n (0.2 mmol) was then added with MeOH (1.75-1 mL). After the corresponding reaction time (t2) (see Table I and Table Ibis), the product was purified by filtration or by column chromatography. Yields are reported in Table I and Table Ibis and pure compounds were obtained as stable solids.

As the rapid development of chemical substances, we look forward to future research findings about 137848-28-3

Reference£º
Patent; UNIVERSIDAD DE ZARAGOZA; CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC); MARQUEZ LOPEZ, Maria Eugenia; ALEGRE REQUENA, Juan Vicente; PEREZ HERRERA, Raquel; (70 pag.)WO2016/5407; (2016); A1;,
Chiral Catalysts
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63126-47-6, (S)-2-(Methoxymethyl)pyrrolidine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63126-47-6

To a 100 mL RBF, was [ADD ][~)-^-INETHOXYMETHYL-PYNOLIDINE] (0.172 g, 1.5 mmol), and 50 mL [DICHLOROME ; HANE] at [0 oC] under nitrogen. 0.35 mL diisopropylethylamine (2.0 mmol) was added drop wise, and stirred for 10 min. 2- [CHLORO-6- (2-CHLOROPYRIDIN-4-YL)-3-METHYL-5-M-TOLYL-3H-PYRIMIDIN-4-ONE] (0.345 g, 1.0 mmol) was added in one portion, and stirred at [0 oC] to rt for 12 h. The mixture was diluted with 100 mL dichloromethane, washed with sat. [NAHC03] and brine. After purified by flash chromatography, the title compound was obtained in 0.40 g as pale yellow solid. MS (ES+): 425 [(M+H) +.]

As the paragraph descriping shows that 63126-47-6 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; WO2003/99808; (2003); A1;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2133-34-8,(S)-Azetidine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Step A. N-(2-Thiophene-sulfonyl)-azetidine-2(S)-carboxylic Acid To a magnetically stirred mixture of azetidine-2(S)-carboxylic acid (1.0 g, 10 mmol) and Na2CO3 (2.1 g, 20 mmol) in 30 mL of water at 0 C. was added thiophene-2-sulfonyl chloride (1.8 g, 10 mmol), and the reaction was allowed to slowly warm up to room temperature overnight. The reaction was quenched by careful addition of concentrated HCl at 0 C. to pH above 2, and the product was extracted with EtOAc (3*15 mL). The extracts were dried over Na2SO4, and concentrated to dryness to provide the title compound as a white solid, which is >90% pure by 1H-NMR and used without further purification. 400 MHz 1H NMR (CD3OD): delta 2.2-2.4 (m, 2H), 3.7-3.9 (m, 2H), 4.42 (dd, 1H), 7.30 (dd, 1H), 7.75 (dd, 1H), 7.95 (dd, 1H)., 2133-34-8

As the paragraph descriping shows that 2133-34-8 is playing an increasingly important role.

Reference£º
Patent; Merck & Co., Inc.; US6645939; (2003); B1;,
Chiral Catalysts
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N,N’-Bis(salicylidene)-1,2-propanediamine, cas is 94-91-7, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,94-91-7

A mixture of H2salipn (28.2mg, 0.100mmol) and [Ru(PPh3)3Cl2] (95.8mg, 0.100mmol) inTHF (30mL) was refluxed with stirring for 6 h, during which there was a color changefrom brown to dark green. The solvent was evaporated in vacuo, and the residue waswashed with diethyl ether (5mL 2) and hexane (5mL 2). Recrystallization fromCH2Cl2/hexane afforded black block crystals of 11.5CH2Cl2 in 7 days. Yield: 33.4mg,55.6% (based on Ru). IR (KBr disc, cm-1): 1594 (C=N), 1314 (Ar-O); MS (FAB): m/z 679[M], 644 [M – Cl], 417 [M – PPh3]. Anal. Calcd. for C35H31N2O2PClRu1.5(CH2Cl2) (%): C,54.41; H, 4.26; N, 3.48. Found: C, 54.47; H, 4.23; N, 3.50.

As the rapid development of chemical substances, we look forward to future research findings about 94-91-7

Reference£º
Article; Ji, Jiao; Chen, Xin; Wang, Chang-Jiu; Jia, Ai-Quan; Zhang, Qian-Feng; Journal of Coordination Chemistry; vol. 72; 3; (2019); p. 480 – 490;,
Chiral Catalysts
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1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, cas is 250285-32-6, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,250285-32-6

A mixture of 1,3-bis(2,6-diisopropylphenyl)imidazolium chloride(0.425 g, 1.0 mmol), [Cp*IrCl2]2 (0.398 g, 0.5 mmol), and K2CO3(0.484 g, 3.5 mmol) in anhyd THF (8 mL)-CH2Cl2 (2 mL) wasstirred at 24 C for 10 h under N2. The resulting suspension wasstirred at 60 C for 24 h under N2, then concentrated to dryness. Afterthe addition of CH2Cl2 (10 mL) to the residue, the resulting suspensionwas filtered through Celite. The filtrate was concentrated todryness to give the iridium complex 2 as a brownish orange solid(0.748 g, 0.963 mmol, 96%).IR (ATR, ZnSe): 1659 cm-1 (CO2).1H NMR (500 MHz, CD2Cl2): delta = 7.43 (t, J = 8.0 Hz, 2 H), 7.33 (d,J = 8.0 Hz, 4 H), 7.09 (s, 2 H), 2.99-2.94 (m, 4 H), 1.45 (d, J = 7.0Hz, 12 H), 1.21 (s, 15 H), 1.06 (d, J = 6.0 Hz, 12 H).13C{1H} NMR (126 MHz, CD2Cl2): delta = 168.1, 165.9, 138.1, 130.1,126.4, 124.2, 87.2, 29.0, 27.2, 23.5, 9.4.Anal. Calcd for C38H51IrN2O3¡¤H2O: C, 57.48; H, 6.73; N, 3.53.Found: C, 57.40; H, 6.54; N, 3.57.

As the rapid development of chemical substances, we look forward to future research findings about 250285-32-6

Reference£º
Article; Yamada, Yoichim. A.; Ohta, Hidetoshi; Yuyama, Yoshinari; Uozumi, Yasuhiro; Synthesis; vol. 45; 15; (2013); p. 2093 – 2100;,
Chiral Catalysts
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