Day: September 16, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.351498-10-7,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),as a common compound, the synthetic route is as follows.

In a nitrogen atmosphere, add to the reactor,2,2 ‘-[(1,1,2,2-tetramethyl-1,2-ethylenediyl) bis (nitromethyl)] bis [4,6-bis (1,1-dimethyl (Ethyl)] phenol, 16.46g (30mmol),21.6 g (152 mmol) of boron trifluoride-ether complex,300ml toluene20 g (152 mmol) of N, N-diisopropylethylamine was stirred with heating at 40 C for 2.5 hours.Cool to room temperature, add 300ml of water, and separate the filtrate into organic and aqueous layers.The organic layer was washed twice with a saturated sodium carbonate aqueous solution and dried over magnesium sulfate.The obtained solid was recrystallized from toluene (150 ml) and ethanol (750 ml),This gave 18.78 g of crude product. The crude product is under pressure 3 ¡Á 10-3Pa,Sublimation at a temperature of 225 C gave compound [69] (light yellow solid)., 351498-10-7

351498-10-7 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) 135404188, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; TORAY ADVANCED MATERIALS RESEARCH LABORATORIES (CHINA) CO., LTD.; WAN, PENG; JIN, GUANGNAN; IKEDA, TAKESHI; LI, JINCAI; TANAKA, DAISAKU; (48 pag.)TW2019/25212; (2019); A;,
Chiral Catalysts
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22795-99-9, (S)-(1-Ethylpyrrolidin-2-yl)methanamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(S)-ethyl 2-(2,6-(UfIuOrO-S-JOdOnJCOtJnOyI)-S-(Tl -ethylpyrrolidin-2-yl)methylamino)acrylateEthyl 2-(2,6-difluoro-5-iodonicotinoyl)-3-(dimethylamino)acrylate (Intermediate 37, 0.500 g, 1.10 mmol) was taken up THF (40 mL) and cooled to 0 0C for 10 min and then (S)-(I- ethylpyrrolidin-2-yl)methanamine (0.153 mL, 1.10 mmol) was added and stirred at room temperature for 2 min. The reaction mixture was quenched with sat NH4Cl diluted with EtOAc and separated, dried, and solvent removed. The residue was purified by a 0-5percent gradient on the ISCO of DCM/Methanol to give (S)-ethyl 2-(2,6-difluoro-5-iodonicotinoyl)-3- ((l-ethylpyrrolidin-2-yl)methylamino)acrylate (0.36Og, 67percent) as a red oil. MS (ES) (M+H)+: 494 for Ci8H22F2IN3O3, 22795-99-9

The synthetic route of 22795-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BIFULCO, Neil; CHOY, Allison, Laura; QUIROGA, Olga; SHERER, Brian; WO2010/136817; (2010); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Add ligand L2690mg (2.0mmol), copper powder 640mg (10.0mmol), 30 mL of water in a 50mL flask, 60 ~ 70 oil bath, the reaction was stirred for 24 hours, the reaction mixture was cooled to room temperature, filtered, the filter cake was washed 3 times with water, the filter cake dissolved in acetonitrile and filtered to remove unreacted copper powder, the solvent was evaporated under reduced pressure to give 520mg as colorless crystals, a yield of 65%.

141556-45-8, The synthetic route of 141556-45-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; China Petroleum & Chemical Corporation Shanghai Research Institute of Petrochemical.; Liu, Bo; Jin, Zhaosheng; Lu, Jiangang; Li, Xianming; Zhou, Haichun; (13 pag.)CN105585584; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.351498-10-7,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),as a common compound, the synthetic route is as follows.

Compound Int-1a (733 mg, 1.33 mmol) was taken up in ethanol (10 mL) and the resulting suspension was heated to 80 C. and allowed to stir at this temperature for 5 minutes. Compound Int-1b (236 mg, 1.33 mmol) was then added and the resulting reaction was allowed to stir at 80 C. for an additional 2 hours. The reaction was then cooled to room temperature using in an ice bath and the reaction mixture was filtered. The collected red solid was dried under vacuum to provide compound Int-1c (579 mg, 72%)., 351498-10-7

The synthetic route of 351498-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck Sharp & Dohme Corp.; Girijavallabhan, Vinay; Njoroge, F. George; Bogen, Stephane; Bennett, Frank; Verma, Vishal; Arasappan, Ashok; Chen, Kevin X.; Huang, Ying; Kerekes, Angela; Nair, Latha; Pissarnitski, Dimitri; Dang, Qun; Davies, Ian; Olsen, David B.; Stamford, Andrew; Vacca, Joseph P.; US2014/206640; (2014); A1;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22795-99-9,(S)-(1-Ethylpyrrolidin-2-yl)methanamine,as a common compound, the synthetic route is as follows.

To 22 mg (0.039 mmol) of acid 164 dissolved in DMF (700 muL) was added (S)-2-aminoethyl)-1-ethylpyrrolidine (20 mg, 0.16 mmol), DIEA (27 muL, 0.16 mmol) and HBTU (44 mg, 0.12 mmol). The reaction mixture was stirred at rt for 3 h and then diluted with methanol (800 muL). The crude product was purified by HPLC and fractions containing the desired product were combined and lyophilized to afford 5 mg (20percent) of 156 as a fluffy white solid. MS (ESI(+)) m/e 677.4 (M+H)+., 22795-99-9

The synthetic route of 22795-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Infinity Pharmaceuticals, Inc.; US2006/25460; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.137848-28-3,(R)-2′-amino-[1,1′-binaphthalen]-2-ol,as a common compound, the synthetic route is as follows.

To a magnetically stirred solution of R-(+)-2-amino-1,1′-binaphthalen-2-ol (0.206 g, 0.722 mmol) in DMAC (15 mL) was slowly added a solution of terephthaloyl chloride (0.0733 g, 0.361 mmol) in DMAC (10mL). After the addition was complete, the reaction mixture was stirred at room temperature for 24h and then concentrated in vacuo to give a crude tan solid. The solid was dissolved in CHCl3 (300 mL) and washed with water (3¡Á100 mL) and brine (50 mL). The organic phase was dried over anhydrous sodium sulfate and then concentrated in vacuo to furnish monomer 3RR (85% yield) as a light tan powder. mp: >250C (decomposition). 1H NMR (DMSO-d6, 500MHz) delta 9.74 (s, 2H), 8.83 (s, 2H), 8.15-8.18 (m, 2H), 8.03-8.07 (m, 2H), 7.97-8.02 (m, 4H), 7.91-7.95 (m, 2H), 7.43-7.48 (m, 2H), 7.37-7.41 (m, 2H), 7.24-7.33 (m, 4H), 7.09-7.17 (m, 8H), 6.86-6.90 (m, 2H); MS m/e: 701.24 ([M]H+). [alpha]D=(+)76 (c=0.130g/dL, THF)., 137848-28-3

As the paragraph descriping shows that 137848-28-3 is playing an increasingly important role.

Reference£º
Article; Lynch, Joseph G.; Jaycox, Gary D.; Polymer; vol. 55; 16; (2014); p. 3564 – 3572;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.351498-10-7,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),as a common compound, the synthetic route is as follows.

Preparation of Cobalt(II) ComplexA 50 mL flask was charged with N,N’-bis(3,5-di-tert-butylsalicylidene)-l, 1,2,2- tetramethylethenediamine (0.4302 g, 0.78 mmol, 1.0 equiv), EtOH (17 mL), and Co(OAc)2 (0.1385 g, 0.78 mmol, 1.0 equiv). The mixture was degassed and then heated to reflux under nitrogen for 3 h, cooled to room temperature. The precipitate was filtered and the purple solid was washed with EtOH (10 mL) and dried under high vacuum to give 0.3533 g (75%) of the cobalt(II) complex., 351498-10-7

The synthetic route of 351498-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; CLAREMON, David, A.; WO2010/91067; (2010); A2;,
Chiral Catalysts
Chiral catalysts – SlideShare

14098-24-9, Benzo-18-crown 6-Ether is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product.

14098-24-9, As the paragraph descriping shows that 14098-24-9 is playing an increasingly important role.

Reference£º
Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare

22795-99-9, (S)-(1-Ethylpyrrolidin-2-yl)methanamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Step 2. 3-(Benzylamino)- or 3-(arylamino)-4-methoxycyclobut-3-ene-1,2-dione 18a ? 18f (1.0 equiv.) was suspended in MeOH (0.07 M) and the amine 19a, 19b or 19c (1.0 equiv.) was added. The resulting mixture was stirred at ambient temperature for 24 hours. The mixture was then filtered and the collected solid residue was washed with ice-cold MeOH and dried in vacuo to afford the corresponding squaramides 1 ? 6., 22795-99-9

As the paragraph descriping shows that 22795-99-9 is playing an increasingly important role.

Reference£º
Article; Kristianslund, Renate; Aursnes, Marius; Tungen, J¡ãrn Eivind; Hansen, Trond Vidar; Tetrahedron Letters; vol. 57; 47; (2016); p. 5232 – 5236;,
Chiral Catalysts
Chiral catalysts – SlideShare

141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The silver(I) N-heterocyclic carbene complexes Ag(I)-NHCs were synthesized according to the Lin?s Ag2O method. To a solution of 1 mmol of NHC precursors (1,3-disubstituted imidazolinium chloride salts) in 5 mL of DCM, 0.5 mmol of Ag2O was added and the mixture was stirred at room temperature for 18 h. Later the reaction mixture was filtered through a celite and concentrated under vacuo to obtain the desired Ag(I)-NHC catalysts as a white crystalline solids.

141556-45-8, As the paragraph descriping shows that 141556-45-8 is playing an increasingly important role.

Reference£º
Article; Thirukovela, Narasimha Swamy; Balaboina, Ramesh; Kankala, Shravankumar; Vadde, Ravindhar; Vasam, Chandra Sekhar; Tetrahedron; vol. 75; 18; (2019); p. 2637 – 2641;,
Chiral Catalysts
Chiral catalysts – SlideShare