Day: September 24, 2020

250285-32-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, cas is 250285-32-6,the chiral-catalyst compound, it is a common compound, a new synthetic route is introduced below.

Under inert atmosphere, 1,3-bis-(2,6-diisopropylphenyl)imidazolium chloride (1.59 g,3.74 mmol, 1.00 equiv.) was dissolved in dichloromethane (170 mL) and silver(I) oxide (0.478 g,2.06 mmol, 1.10 equiv.) was added. The mixture was stirred at room temperature for 25 h and then iodine (1.04 g, 4.10 mmol, 1.10 equiv.) in dichloromethane (50 mL) was added slowly andstirred overnight. The mixture was deactivated by NaS2O3, the organic layer was separated anddried over MgSO4. After removal of the solvent, the residue was dissolved in methanol and asolution of NaBPh4 (1.51 g, 4.40 mmol, 1.18 equiv.) in methanol (15 mL) was added. Theforming solid was filtrated off and dried in vacuum to afford the desired product as a colorlesssolid (2.25 g, 2.69 mmol, 72 %).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, 250285-32-6

Reference£º
Article; Von Der Heiden, Daniel; Detmar, Eric; Kuchta, Robert; Breugst, Martin; Synlett; vol. 29; 10; (2018); p. 1307 – 1313;,
Chiral Catalysts
Chiral catalysts – SlideShare

Name is 1,4,7,10,13-Pentaoxacyclopentadecane, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 33100-27-5, its synthesis route is as follows.

The (2S,4R)-4-(tert-butyldimethylsilyloxy)-4-[3-(8-chloro-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)phenyl]-2-methyltetrahydropyran used as a starting material was obtained as follows: Sodium hydride (50percent dispersion in mineral oil, 0.3 g) was added portionwise to a stirred mixture of (2S,4R)-4-hydroxy-4-(3-iodophenyl)-2-methyltetrahydropyran (1.64 g), 1,4,7,10,13-pentaoxacyclopentadecane (hereinafter 15-crown-5, 0.05 g) and THF (30 ml) and the mixture was stirred at ambient temperature for 30 minutes. Tert-butyldimethylsilyl chloride (0.9 g) was added and the mixture was stirred and heated to 60¡ã C. for 6 hours. The mixture was cooled to ambient temperature and partitioned between diethyl ether and a dilute aqueous ammonium chloride solution. The organic solution was washed with brine, dried (Na2 SO4) and evaporated. The residue was purified by column chromatography using increasingly polar mixtures of hexane and ethyl acetate as eluent. There was thus obtained (2S,4R)-4-(tert-butyldimethylsilyloxy)-4-(3-iodophenyl)-2-methyltetrahydropyran (1.9 g, 88percent) as an oil.

33100-27-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,33100-27-5 ,1,4,7,10,13-Pentaoxacyclopentadecane, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Zeneca Limited; Zeneca Pharma S.A.; US5478842; (1995); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

137848-28-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. (R)-2′-amino-[1,1′-binaphthalen]-2-ol, cas is 137848-28-3,the chiral-catalyst compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Modified method [69]. Salicylaldehyde (1.22 g, 10.0 mmol) was mixed with (R)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g,10.0 mmol) in dry toluene (50 mL). A few 4 A molecular sieves were added, and the solution was warmed up to 70 C and kept for two days at this temperature. The solution was filtered, and the filtrate was concentrated to 10 mL. Yellow microcrystals 1H2 were isolated when this solution was kept at -20 C for two days. Yield: 3.31 g (85%). M.p.: 120-122 C. 1H NMR (C6D6): d 12.45 (s, 1H, OH), 8.23 (s, 1H, CHN), 7.83 (m, 2H, aryl), 7.74 (m, 2H,aryl), 7.57 (d, J = 8.4 Hz, 1H, aryl), 7.36 (m, 1H, aryl), 7.28 (m, 2H, aryl), 7.17 (m, 2H, aryl), 7.11 (m, 2H, aryl), 6.96-6.83 (m,3H, aryl), 6.62 (t, J = 7.2 Hz, 1H, aryl), 4.73 (s, 1H OH). These spectroscopicdata were in agreement with those reported in the literature [69].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of (R)-2′-amino-[1,1′-binaphthalen]-2-ol, 137848-28-3

Reference£º
Article; Chen, Liang; Zhao, Ning; Wang, Qiuwen; Hou, Guohua; Song, Haibin; Zi, Guofu; Inorganica Chimica Acta; vol. 402; (2013); p. 140 – 155;,
Chiral Catalysts
Chiral catalysts – SlideShare

250285-32-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, cas is 250285-32-6,the chiral-catalyst compound, it is a common compound, a new synthetic route is introduced below.

Under the protection of nitrogen, to the reaction tube is sequentially added imidazole salt IPr¡¤HCl (1.1mmol), palladium chloride (1.0mmol), potassium carbonate (2.2mmol), tetrahydrofuran (5.0 ml) and isoquinoline (2.0mmol). The mixture is placed in the oil bath heated reaction (80 C) 12 hours. Stopping the reaction, cooling to room temperature, pressure reducing turns on lathe does solvent, rapid column chromatography separation to obtain a yellow solid product 0.1148g, yield 83%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, 250285-32-6

Reference£º
Patent; Wenzhou University; Shao Lixiong; Lu Jianmei; Liu Feng; (23 pag.)CN106892945; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

250285-32-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, cas is 250285-32-6,the chiral-catalyst compound, it is a common compound, a new synthetic route is introduced below.

IPr-HCI (82.04 mg, 0.193 mmol), [Pd(allyl)(M-CI)]2 (35.3 mg, 0.0965 mmol), a magnetic stir bar and acetone (0.8 mL) were charged to a vial . The mixture was stirred at 60 C for 1 h. Then the solvent was removed and dried under vacuum. The product was obtained as a yellow powder in a 99% (117 mg). XH NMR (400 MHz, CDCIs): delta (ppm) = 9.16 (s, 1H), 8.28 (d, J = 1.62 Hz, 2H), 7.54-7.50 (m, 2H), 7.32 (d, J = 7.17 Hz, 4H), 5.16-5.10 (m, 1H), 3.76 (s, 2H), 2.67 (d, J = 11.57 Hz, 2H), 2.48-2.44 (m, 4H), 1.27 (d, J = 6.79 Hz, 12H), 1.20 (d, J = 7.20 Hz, 12H).13C {XH} NMR (100 MHz, CDCIs): delta (ppm) = 5144.9 (C), 136.8 (CH), 131.8 (C), 129.7 (C), 127.3 (CH), 124.4 (CH), 108.9 (C), 60.3 (CH), 28.8 (CHs), 24.4 (CHs), 23.8 (CHs). Elemental analysis: Expected : C 59.07, H 7.27 N 4.59, Found : C 58.90 H 7.17 N 4.57.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, 250285-32-6

Reference£º
Patent; UMICORE AG & CO. KG; NOLAN, Steven P.; (47 pag.)WO2018/115029; (2018); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is (S)-(1-Ethylpyrrolidin-2-yl)methanamine, and cas is 22795-99-9, its synthesis route is as follows.

General procedure: Benzoic acid derivatives (1 mmol) and heterogeneous catalyst (10 mg) were mixed for 5 min in 1 mL of anhydrous toluene. Then, the amine (1.2 mmol) was added and the mixture was reacted under ultrasound for about 15-60 min at room temperature. After completion of the reaction (monitored by TLC), the catalyst was separated through filtration and the solvent was removed in vacuo. The obtained residue was dissolved in chloroform (10 ml) and washed with 10% NaHCO3 (10 ml) and HCl (1 M, 10 ml). The organic layer was extracted and dried over Na2SO4 and concentrated under reduced pressure to afford the amide, which was purified by recrystallization or column chromatography.

22795-99-9, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,22795-99-9 ,(S)-(1-Ethylpyrrolidin-2-yl)methanamine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Ahmadi, Masoumeh; Moradi, Leila; Sadeghzadeh, Masoud; Research on Chemical Intermediates; vol. 44; 12; (2018); p. 7873 – 7889;,
Chiral Catalysts
Chiral catalysts – SlideShare

22795-99-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. (S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9,the chiral-catalyst compound, it is a common compound, a new synthetic route is introduced below.

Reaction 5:In the glovebox, 500 ?? of the stock solution was transferred to the vial called chamber 2 of our 2-chamber system. Then an injection vial with the 5A MS (750 mg) was installed in the chamber 2 and the system was sealed with a crimp-cap (Aluminium Cap 20mm, silicone/PTFE). Palladium catalysed [nC]carbonylation reactions was then run following the previous described protocol. 307 MBq of crude product was isolated after flushing of the 2-chamber system. Analytical HPLC was run on an aliquot of the crude (Phenomenex Luna 5? C18 100A, 250×4.6 mm 5 micron, 35percent Acetonitrile 65percent NaH2P04 70mM, 2 mL/min). The HPLC chromatogram from the radio-channel showed that the desired[nC]raclopride was 11percent radiochemically pure.

The chemical industry reduces the impact on the environment during synthesis,22795-99-9,(S)-(1-Ethylpyrrolidin-2-yl)methanamine,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; AARHUS UNIVERSITET; REGION MIDTJYLLAND; SKRYDSTRUP, Troels; LINDHARDT, Anders Thyboe; G?GSIG, Thomas; TAANING, Rolf Hejle; AUDRAIN, Helene; BENDER, Dirk Andreas; FRIIS, Stig Duering; WO2013/41106; (2013); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is 1,3-Dimesityl-1H-imidazol-3-ium chloride, and cas is 141556-45-8, its synthesis route is as follows.

A butterfly for the keto-carbonyl of bridge [2Fe2Se] kind of iron-iron hydrogenase models object 5 preparation method, the chemical formula of the model [( mu-SeCH 2 (CO) CH 2 Se-mu)] Fe 2 (CO) 5 (IMes) (IMes=1,3-b (2, 4, 6-trimethyl phenyl) imidazole-2-carbene), shown in the preparing process is as follows. Specific preparation steps are as follows: 1) in high purity under the protection of nitrogen, with stirring to the drying of the magneton 100 ml reaction flask by adding 455 mg (1.336mmol) 1,3-bis (2, 4, 6-trimethyl phenyl) imidazole hydrochloride and 20 ml tetrahydrofuran, shall be mixed solution; 2) in the above-mentioned mixed solution is added with 1.6Mn-BuLi solution 1 ml, stirring the mixture at room temperature for 20 min, the reaction liquid obtained, the above-mentioned reaction solution is then filtered, and the filtrate by adding in 165 mg (0.334mmol) 1 further reaction to obtain a reaction mixture; 3) the above-mentioned reaction mixture, the solvent is pumped under reduced pressure, the residue is extracted with methylene chloride, the volume ratio of 1:1 mixture of dichloromethane-petroleum ether as a developing agent thin layer chromatographic separation, collection red the main ribbon, obtain a red solid 159 mg, the chemical formula is [( mu-SeCH 2 (CO) CH 2 Se-mu)] Fe 2 (CO) 5 (IMes) (5), the yield is 62%.

141556-45-8, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,141556-45-8 ,1,3-Dimesityl-1H-imidazol-3-ium chloride, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Nankai University; Song, Licheng; Han, Xiaofeng; Song, Fengtao; (7 pag.)CN105294777; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride, and cas is 173035-10-4, its synthesis route is as follows.

General procedure: [HIPr]2[PdCl4]: 0.45 g (1.0 mmol) of [HIPr]Cl was added to thesolution of 0.14 g (0.48 mmol) PdCl2(cod) in hot CH3CN (5 mL). Themixture was heated for 15 min, until the yellow solution becamered. The solution was cooled to room temperature and solventwas removed under reduced pressure. The product was precip-itated by addition of diethyl ether (2-3 mL). Product yield: 85%;elemental analysis calcd. (%) for PdCl4C54H78N4: C 62.88, H 7.62,N 5.46; found: C 62.37, H 7.46, N 5.40.1H NMR(500 MHz, CD3CN,25C, TMS): = 8.49 (s, 2H, N CH N); 7.57 (t, J(H,H) = 7.8 Hz, 4H,Ar); 7.42 (d, J(H,H) = 7.8 Hz, 8H, Ar); 4.48 (s, 8H, CH2CH2); 3.10(m, J(H,H) = 6.9 Hz, 8H, CH); 1.40 (d, J(H,H) = 6.9 Hz, 24H, CH3); 1.26(d, J(H,H) = 6.9 Hz, 24H, CH3,);13C NMR (125.75 MHz, CD3CN, 25C,TMS): = 160.0 (N CH N); 147.2 (Ar); 131.0 (Ar); 125.5 (Ar); 53.7(CH2CH2); 28.5 (CH); 24.0 (CH3); 23.5 (CH3).

173035-10-4, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,173035-10-4 ,1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Silarska; Trzeciak; Pernak; Skrzypczak; Applied Catalysis A: General; vol. 466; (2013); p. 216 – 223;,
Chiral Catalysts
Chiral catalysts – SlideShare

Benzo-18-crown 6-Ether, cas is 14098-24-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.

General procedure: A modification of the previously reported procedure23 was used. Commercially available Eaton’s reagent (ca. 8 ml that corresponds to 6.28 mmol of phosphorus(V) oxide) and acetic acid (0.20 ml, 3.45 mmol) were mixed at room temperature. Then naphtho-15-crown-5 ether (1 g, 3.14 mmol) was added. The reaction mixture was stirred at room temperature for ca. 6 h and then poured into water. The suspension was extracted with dichloromethane and the combined organic phases were washed with water. Removal of the dried (MgSO4) solvent gave a dark brown oil, which upon repeated extractions with hot heptane, afforded the product as an off-white solid (1.02 g, 90%), mp 126-129 C.

14098-24-9, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,14098-24-9 ,Benzo-18-crown 6-Ether, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Paramonov, Sergey V.; Lokshin, Vladimir; Smolentsev, Artem B.; Glebov, Evgeni M.; Korolev, Valeri V.; Basok, Stepan S.; Lysenko, Konstantin A.; Delbaere, Stephanie; Fedorova, Olga A.; Tetrahedron; vol. 68; 38; (2012); p. 7873 – 7883;,
Chiral Catalysts
Chiral catalysts – SlideShare