Day: October 12, 2020

trans-Cyclohexane-1,2-diamine, cas is 1121-22-8, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,1121-22-8

A solution of thiazole-2-carboxaldehyde (2.00 g, 17.7 mmol) in N,N-dimethylformamide (4.0 mL) was swirled as trans-N,N’-1,2-diaminocyclohexane (1.05 mL, 8.74 mmol) was added, which resulted in slight warming. After three days at ambient temperature, yellowish crystals were collected by filtration, rinsed with N,N-dimethylformamide (10 mL, in portions) and water (10 mL, in portions), and dried in vacuo (trans-N,N’-bis(thiazol-2-ylmethylene)-1,2-diaminocyclohexane, 1.91 g). After three days, a second crop of yellowish crystals was likewise collected from the initial filtrate (trans-N,N’-bis(thiazol-2-ylmethylene)-1,2-diaminocyclohexane, 0.33 g, 84.3% total yield). 1H NMR (CDCl3, delta): 8.36 (d, J = 0.8, 2H, imine), 7.81 (d, J = 3.2, 2H, Thz), 7.31 (dd, J = 3.2, 0.8, 2H, Thz), 3.48 (m, 2H, NCH), 1.84 (m, 4H, cyclohexyl), 1.79 (m, 2H, cyclohexyl), 1.47 (m, 2H, cyclohexyl). 13C NMR (CDCl3, delta): 167.1 (Thz 2), 154.7 (Thz 4,5), 143.8 (Thz 4,5), 121.3 (imine), 73.1 (NCH), 32.4 (cyclohexyl), 24.1 (cyclohexyl). Anal. Calc. for C14H16N4S: C, 55.23; H, 5.30; N, 18.40. Found: C, 55.29; H, 5.55; N, 18.37%.

As the rapid development of chemical substances, we look forward to future research findings about 1121-22-8

Reference£º
Article; Bennov, Rachel R.; Berko, David A.; Burgess, Samantha A.; Dimeglio, John L.; Kalman, Steven E.; Ludlum, Jeffrey M.; Nash, Bradley W.; Palomaki, Peter K.B.; Perlow, Daniel B.; Rubin, Jacob A.; Saunders, Janet E.; Scarselletta, Sarah V.; Kastner, Margaret E.; Pike, Robert D.; Sabat, Michal; Keane, Joseph M.; Inorganica Chimica Acta; vol. 438; (2015); p. 64 – 75;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.602-09-5,[1,1′-Binaphthalene]-2,2′-diol,as a common compound, the synthetic route is as follows.

602-09-5, [ 1 , 1 ,-Binaphthalene]-2,2′-diol (30.0 g, 0. 1 05 mo I, 1 .0 eq. ) was placed in a flask and flushed with argon. Anhydrous toluene (300 m L ) was added, followed by trifluoromethanesulfonic acid (1 1.7 ml., 0.2 1 0 mo I, 2.0 eq. ). After further degassing, the mixture was re fluxed for 48 hours. After cool ing, the organic layer was extracted with water (500 m l. ), dried over gSO i, and reduced under vacuum until precipitation. Hexane (300 ml.) was then added, and the resulting suspension was stirred for 2h before being filtered off. This solid was dissolved in DC I, and filtered over silica (elution with hexane / DCM 2 : 1 ). The volume of the fraction obtained was reduced to ca. 50 m l., and the resulting crystals were filtered off, yielding the title compound.

The synthetic route of 602-09-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVALED GMBH; DENKER, Urlich; ZOeLLNER, Mike; GRAeF, Katja; SENKOVSKYY, Volodymyr; WALLIKEWITZ, Bodo; SCHOLZ, Johannes; FREY, Julien; (143 pag.)WO2016/180891; (2016); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

1121-22-8, trans-Cyclohexane-1,2-diamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mortar were added 3,5-di-tert-butyl-2-hydroxybenzaldehyde (0.468 g, 2 mmol) and trans-cyclohexane-1,2-diamine (0.114 g,0.123 mL, 1 mmol), and these were mixed over 10 min. The product was recrystallized (CH2Cl2/EtOH 1:9) to give 1a as a bright yellow solid; yield: 0.487 g (89%)., 1121-22-8

The synthetic route of 1121-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Civicos, Jose F.; Coimbra, Juliana S. M.; Costa, Paulo R. R.; Synthesis; vol. 49; 17; (2017); p. 3998 – 4006;,
Chiral Catalysts
Chiral catalysts – SlideShare

trans-Cyclohexane-1,2-diamine, cas is 1121-22-8, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,1121-22-8

General procedure: To a mortar were added 3,5-di-tert-butyl-2-hydroxybenzaldehyde (0.468 g, 2 mmol) and trans-cyclohexane-1,2-diamine (0.114 g,0.123 mL, 1 mmol), and these were mixed over 10 min. The product was recrystallized (CH2Cl2/EtOH 1:9) to give 1a as a bright yellow solid; yield: 0.487 g (89%).

As the rapid development of chemical substances, we look forward to future research findings about 1121-22-8

Reference£º
Article; Civicos, Jose F.; Coimbra, Juliana S. M.; Costa, Paulo R. R.; Synthesis; vol. 49; 17; (2017); p. 3998 – 4006;,
Chiral Catalysts
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(1R,2S)-2-Amino-1,2-diphenylethanol, cas is 23190-16-1, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,23190-16-1

5.0 mL of water and 0.21 mL of 1 N hydrochloric acid was added to 90 mg (0.21 mmol) of a mixture of a sodium salt of (3S)-3-benzyloxycarbonylamino-(R)-1-amino(sulfoamino)phosphinyl-2-piperidone and a sodium salt of (3R)-3-benzyloxycarbonylamino-(S)-1-amino(sulfoamino)phosphinyl-2-piperidone at about 1:1, and 42.6 mg (0.20 mmol) of (1R, 2S)-(-)-2-amino-1,2-diphenylethanol; and the reaction liquid was stirred while being heated. Both compounds were completely dissolved at an inner temperature of about 50C, heating was stopped, and the reaction liquid was left till the inner temperature becomes room temperature. The precipitated crystal was taken through a filter, and 25 mg of a salt of (3R)-3-benzyloxycarbonylamino-(R)-1-amino(sulfoamino) phosphinyl-2-piperidone with (1R,2S)-(-)-2-amino-1,2-diphenylethanol (0.040 mmol, an optical purity (d.e.) of 95%, and a yield of 19%) was obtained. salt of (3R)-3-benzyloxycarbonylamino-(R)-1-amino(sulfoamino)phosphinyl-2-piperidone with (1R,2S)-(-)-2-amino-1,2-diphenylethanol1H-NMR (200MHzFT, TMS, CD3OD) 1.63-2.02 (3H, m), 2.12-2.30 (1H, m), 3.50-3.88 (2H, m), 4.17-4.30 (1H, m), 4.46 (1H, d, J=4.0 Hz), 5.08 (2H, s), 5.22 (1H, d, J=4.0 Hz), 7.04-7.41 (15H, m)

As the rapid development of chemical substances, we look forward to future research findings about 23190-16-1

Reference£º
Patent; Nippon Kayaku Kabushiki Kaisha; ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI; EP1457494; (2004); A1;,
Chiral Catalysts
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D-Phenylalanine, cas is 673-06-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,673-06-3

General procedure: D-amino acid (10 mmol) was dissolved in 60 mL of dry methanol. Under an argon atmospherepotassium carbonate (40 mmol) and CuSO4 ¡Á 5H2O (0.1 mmol) were added and the mixture wasstirred for 15 min. 1H-imidazole-1-sulfonyl azide hydrochloride (12 mmol) was added over a periodof 30 min and the resulting mixture was stirred for 17 h at ambient temperature and under an argonatmosphere. Methanol was removed under reduced pressure and 50 mL of water was added to thecrude product. The pH was adjusted to 3 with 1 M HCl and extracted with ethyl acetate (3 ¡Á 40 mL).The organic phase was washed with brine (1 ¡Á 30 mL), dried with Na2SO4 and evaporated underreduced pressure, and the resulting oil residue was purified by flash column chromatography (SiO2)eluting with dichloromethane and methanol with 1% of acetic acid

As the rapid development of chemical substances, we look forward to future research findings about 673-06-3

Reference£º
Article; ?ula, Ale?; B?dziak, Izabela; Kikelj, Danijel; Ila?, Janez; Marine Drugs; vol. 16; 11; (2018);,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-22-8,trans-Cyclohexane-1,2-diamine,as a common compound, the synthetic route is as follows.

Into a solution containing 1,6-diisocyanatohexane (4.04 grams, 24.0 mmol; obtained from Sigma-Aldrich Fine Chemicals) and anhydrous tetrahydrofuran (100 mL, obtained from Sigma-Aldrich Fine Chemicals) stirring at room temperature was added 1-octanol (3.13 grams, 24.0 mmol, obtained from Sigma-Aldrich Fine Chemicals) and dibutyltin dilaurate (0.15 grams, 0.24 mmol, obtained from Sigma-Aldrich Fine Chemicals) as the catalyst. The mixture was stirred and heated to an internal temperature of about 65 C. The progress of the reaction was monitored by 1H-NMR spectroscopy for the consumption of 1-octanol starting material, indicated by the disappearance of the -CH2OH multiplet, which appears at 3.6 ppm downfield of the intermediate isocyanate product whose signal is located at 3.35 ppm. The mixture was cooled to about 15 C. internal temperature; thereafter, to this mixture was added dropwise a solution of trans-1,2-diaminocyclohexane (1.37 grams, 12 mmol; obtained as a racemic mixture of (1R,2R) and (1S,2S) stereoisomers from Sigma-Aldrich Fine Chemicals) dissolved in anhydrous tetrahydrofuran (10 mL). The mixture was stirred for about 60 minutes while warming up to room temperature, and thickened to form a gelatinous slurry. FTIR spectroscopic analysis of a reaction sample showed very little unreacted isocyanate (peak at 2180 cm-1, sample prepared as a KBr pellet). Residual isocyanate was quenched by addition of 5 mL of methanol. A crystalline product was isolated from the slurry by first adding diethyl ether (20 mL) followed with stirring for approximately 30 minutes to ensure full precipitation out of the gel slurry. The solid was filtered by suction on a paper filter, rinsed with diethyl ether, and then dried in air to give 6.20 grams of off-white solid (77.5% yield). The product was believed to be of the formulae 1H-NMR spectroscopic analysis of the solid was performed in DMSO-d6 (300 MHz) at high temperature (60 C.) and indicated the above structure with the following assigned peaks: 0.90 ppm (multiplet, 3 H integration, -OCH2(CH2)6CH3); 1.05-1.95 ppm (broad multiplets, 24 H integration, 12 methylene protons from 2-ethylhexanol portion, 8 methylene protons from the 1,6-diisocyanatohexane portion, and 4 methylene protons from the cyclohexane ring portion); 2.95 ppm (narrow multiplet, 4 H integration, -NH(CO)NHCH2(CH2)4CH2NH(CO)O); 3.35 ppm (doublet, 1 H integration, tertiary methine proton adjacent to urea group on cyclohexane ring); 3.90 ppm (doublet of doublets, 2 H integration, NH(CO)OCH2(CH2)6CH3; 5.70 ppm and 5.85 ppm (each a broad singlet, 1 H integration, urea NH protons); 7.00 ppm (broad singlet, 1 H integration, urethane NH proton). Elemental analysis calculated for C: 64.19%, H: 10.49%, N: 11.82%; found for C: 64.46%, H: 10.63%, N: 10.69%.

1121-22-8, 1121-22-8 trans-Cyclohexane-1,2-diamine 43806, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Xerox Corporation; US2006/122415; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

[1,1′-Binaphthalene]-2,2′-diol, cas is 602-09-5, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,602-09-5

General procedure: Separately, each of the dihydroxy-substituents, catechol (a), 2,3-dihyroxynaphthalene (b), 2,2′-dihydroxy-1,1′-bisnaphthalene (c) (50 mmol), and NaOH (0.12 mol) were dissolved in 20-25 ml ethanol and 2-chloroethanol (0.12 mol) was added to this solution dropwise over 15 min. After refluxing the reaction mixture for 20 h, the resulting solid was separated by filtration. Ethanol was evaporated in vacuo and the resulting oily product was dissolved in 200 ml chloroform. The chloroform solution was washed with 3% NaOH and then with distilled water until the pH reached neutrality.

As the rapid development of chemical substances, we look forward to future research findings about 602-09-5

Reference£º
Article; Kertmen, Ahmet; Szczygelska-Tao, Jolanta; Chojnacki, Jaros?aw; Tetrahedron; vol. 69; 49; (2013); p. 10662 – 10668;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22795-99-9,(S)-(1-Ethylpyrrolidin-2-yl)methanamine,as a common compound, the synthetic route is as follows.

A mixture of 2-fluoro-5-(1-trityl-1H-benzotriazol-5-yl)-benzaldehyde (368 mg, 0.76 mmol), (S)-(+)-1-ethyl-2-aminomethylpyrrolidine (120 mg, 0.83 mmol) and molecular sieves in 10 mL of methanol was stirred at ambient temperature for 3 h. The mixture was cooled to -78¡ã C., and sodium borohydride (72 mg, 1.9 mmol) was added and the mixture was allowed to warm to room temperature and stirred overnight. The volatiles were removed in vacuo and the residue was diluted with dichloromethane and washed with water. The aqueous phase extracted with dichloromethane, and the combined organic phases were washed with brine, dried over magnesium sulfate, filtered and concentrated to leave the crude product. Chromatography (elution with methanol/dichloromethane) gave 255 mg of product., 22795-99-9

As the paragraph descriping shows that 22795-99-9 is playing an increasingly important role.

Reference£º
Patent; AVENTIS PHARMACEUTICALS INC.; US2008/138413; (2008); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23190-16-1,(1R,2S)-2-Amino-1,2-diphenylethanol,as a common compound, the synthetic route is as follows.

To a 5 L round bottom flask equipped with an overhead stirrer, thermocouple and distillation head, was charged 550 g (2.579 mol) of (1 R,2S)- diphenyl-2-aminoethanol, 457 g (3.868 mol, 1.5eq) of diethylcarbonate, 18 g (0.258 mol, 0.1 eq) of NaOEt in 100 mL of EtOH and 3.5 L of toluene. The reaction was heated until an internal temperature of 90C was reached and EtOH distillation began. The reaction was refluxed until an internal temperature of 110C was reached (7 hours). For every 500 mL of solvent that was removed via the distillation head, 500 mL of toluene was added back to the reaction. A total of about 1.6 L of solvent was removed. The reaction was allowed to cool to room temperature and then filtered on a 3 L coarse fritted funnel with 2 psig N2. Nitrogen was blown over the cake overnight (at)o give 580 g (94% yield) of the titled nom””””” ””d” 9,-..C.U.(at), l:(at)VQ”; ‘I <"Q'.(at)(at) Up(at),.,; ',r1" (at)'(at) (at) (at).(at).(at) (at)-77 1'Cf'; 41i), ..(at)(at) ^(at)''1 I or(at)r(at)1 (at),f3rr:.(at)i ....u..(at) " ' (at).V.(at)_7(at)dli (at) ",-JVV Jc;;;J7Jv (at)L.-, U- -(at)t 'H'o(at)(at)-:J """.v (at)' "(at)(at) fUSD5 -/: q,78V;",j (at)(at)-j -(at), t(at).3J(at):, (at):_/(at).:::: , OJ (at), :=: ?Q(at)':::'::' 23190-16-1, As the paragraph descriping shows that 23190-16-1 is playing an increasingly important role.

Reference£º
Patent; PFIZER PRODUCTS INC.; WO2005/102389; (2005); A2;,
Chiral Catalysts
Chiral catalysts – SlideShare