Day: March 29, 2022

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about N-tert-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer, the main research direction is small cell lung cancer prenylation indole ring cytotoxicity antagonist.COA of Formula: C6H15ClN2O.

Natural prenylated indoles have been proposed as potential anticancer agents. To exploit this discovery for developing new peptide therapeutics, we report the first studies whereby incorporation of prenylated indoles into primary sequences has been achieved. We developed a route to synthesize Nα-Fmoc-protected tryptophan derivatives in which the prenyl group is linked to the N-indole core, using Pd(II)-mediated C-H functionalization of 2-methyl-2-butene. Based on the Substance P antagonist G (SPG), a well-known Small Cell Lung Cancer (SCLC) anticancer agent, we designed a new penta-peptide sequence to include a prenyl moiety on one of the tryptophan residues. The N-tert-prenylated tryptophan analog was assembled into the pentameric peptide using standard solid phase peptide synthesis or liquid phase synthesis by fragment coupling. In vitro screening showed that the N-tert-prenylation of the indole ring on the tryptophan residue located near the C-terminal of the penta-peptide enhanced the cytotoxicity against H69 (IC50 = 2.84 ± 0.14 μM) and DMS79 (IC50 = 4.37 ± 0.44 μM) SCLC cell lines when compared with the unmodified penta-peptide (H69, IC50 = 30.74 ± 0.30 μM and DMS79, IC50 = 23.00 ± 2.07 μM) or the parent SPG sequence (IC50 > 30 μM, both cell lines). SCLC almost invariably relapses with therapy-resistant disease. The DMS79 cell line was established from a patient following treatment with a number of chemotherapeutics (cytoxan, vincristine and methotrexate) and radiation therapy. Treating DMS79 tumor-bearing nude mice provided a human xenograft model of drug resistance to test the efficacy of the prenylated peptide. A low dose (1.5 mg kg-1) of the prenylated peptide was found to reduce tumor growth by ∼30% (P < 0.05) at day 7, relative to the control group receiving vehicle only. We conclude that the availability of the Fmoc-Trp(N-tert-prenyl)-OH amino acid facilitates the synthesis of prenylated-tryptophan-containing peptides to explore their therapeutic potential. Here is a brief introduction to this compound(10466-61-2)COA of Formula: C6H15ClN2O, if you want to know about other compounds related to this compound(10466-61-2), you can read my other articles.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Applied Electrochemistry called Electrochemical reactions of halohydrins. II. Olefins formation, Author is Cipris, D., which mentions a compound: 542-58-5, SMILESS is CC(OCCCl)=O, Molecular C4H7ClO2, Electric Literature of C4H7ClO2.

2-Bromoethanol was reduced to ethylene, 1-bromo-2-propanol to propylene, and 2-bromo-1-indanol to indene on Pb or Cu electrodes with R4N+ electrolytes, in DMF with and without addition of water. Material and current efficiencies were high. H was the only by-product in all cases. This represents a general method for the conversion of bromohydrins to olefins.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Analysis of A2B2 N.M.R. [nuclear magnetic resonance] spectra. II. Nonsymmetrical 1,2-disubstituted ethanes》. Authors are Hirst, Robert C.; Grant, David M..The article about the compound:2-Chloroethyl acetatecas:542-58-5,SMILESS:CC(OCCCl)=O).Category: chiral-catalyst. Through the article, more information about this compound (cas:542-58-5) is conveyed.

cf. CA 58, 4067e. The features of A2B2 proton magnetic resonance spectra of nonsym. 1,2-disubstituted ethanes are discussed in detail. Under certain conditions the magnitudes and signs of all the coupling constants can be obtained for this type of A2B2 spectra. Typical calculated spectra along with several exptl. spectra are given to illustrate these conditions. With one exception, exptl. data are given only for mols. for which all 4 of the coupling constants are obtained. The geminal coupling constants are of opposite sign from the rotationally averaged values for the vicinal couplings. The values of the geminal couplings are approx. those found by other workers in the corresponding monosubstituted methanes. Small vicinal substituent effects on the geminal coupling constants are reported for several of the substituent groups. The assignment of the chem. shift of the particular methylene group is based on the comparison of the A2B2 chem. shifts with the chem. shifts in the related ethyl compounds.

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Reference:
Chiral Catalysts,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, CyTA–Journal of Food called Effect of cocoa roasting time on volatile composition of dark chocolates from different origins determined by HS-SPME/GC-MS, Author is Torres-Moreno, Miriam; Tarrega, Amparo; Blanch, Consol, which mentions a compound: 13925-00-3, SMILESS is CCC1=NC=CN=C1, Molecular C6H8N2, Category: chiral-catalyst.

In this study the volatile composition of six samples of dark chocolates varying in the cocoa roasting time (30.5, 34.5 and 38.5 min) and geog. origin (Ecuador and Ghana) was characterized by headspace solid-phase microextraction (HS-SPME) followed by gas chromatog.-mass spectrometry (GC-MS). One hundred and twenty-one different compounds were identified using a carboxen/polydimethylsiloxane (CAR-PDMS) fiber comprising acids, alcs., aldehydes, alkanes, esters, furans, ketones, nitrogen compounds, pyran derivatives, pyrazines, pyrroles and thiazoles. The effect of roasting time on the volatile composition of chocolates depended on their geog. origin. Principal component anal. (PCA) was applied to volatile composition of the six dark chocolate samples. Eight different groups of compounds were established according to the position of the aroma compounds on the PC plot and accordingly to variation among samples. Therefore, volatile compounds that appeared or disappeared during roasting of cocoa from each origin or both origins were identified.

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Reference:
Chiral Catalysts,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 43142-76-3, is researched, SMILESS is O=C(C(N1)=C(C=O)C2=C1C=CC(Cl)=C2)OCC, Molecular C12H10ClNO3Journal, Organic Chemistry Frontiers called Catalytic enantioselective and regioselective substitution of 2,3-indolyldimethanols with enaminones, Author is Lu, Yi-Nan; Ma, Chun; Lan, Jin-Ping; Zhu, Caiqiang; Mao, Yu-Jia; Mei, Guang-Jian; Zhang, Shu; Shi, Feng, the main research direction is indolylmethylcyclohexenone enantioselective regioselective preparation antitumor activity; indolyl dimethanol cyclic enaminone BINOL catalyst substitution reaction.Reference of Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate.

2,3-Indolyldimethanols as a new class of indolyldimethanols were designed, and the first catalytic asym. substitution of 2,3-indolyldimethanols were established by using cyclic enaminones as nucleophiles, which afforded substitutive products in an enantioselective and regioselective mode (up to 98% ee, all >95 : 5 rr). This reaction represented the first design and application of 2,3-indolyldimethanols in catalytic asym. reactions, which greatly enriched the chem. of indolyldimethanols.

Here is a brief introduction to this compound(43142-76-3)Reference of Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, if you want to know about other compounds related to this compound(43142-76-3), you can read my other articles.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare