Month: March 2022

Formula: C12H10ClNO3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Synthesis and biological activity of functionalized indole-2-carboxylates, triazino- and pyridazino-indoles. Author is El-Gendy, Adel A.; Said, Mohamed M.; Ghareb, Nagat; Mostafa, Yasser M.; El-Ashry, El Sayed H..

Condensation of aryl hydrazines with Et pyruvate gave the resp. hydrazones; Fischer indolization led to substituted-1H-indole-2-carboxylic acid Et esters. The Mannich reaction of these compounds with formaldehyde and morpholine yielded Et 3-(morpholino-methyl)-substituted-1H-indole-2-carboxylates. The 5,7-dichloro-1H-indole-2-carbohydrazide was cyclized with Me orthoformate in DMF to give 6,8-dichloro[1,2,4]triazino[4,5-a]indol-1(2H)-one. Vilsmeier-Haack formylation of substituted-1H-indole-2-carboxylates gave Et 3-formyl-substituted-1H-indole-2-carboxylates whose 2,2′-((5-chloro-2-(ethoxycarbonyl)-1H-indol-3-yl)methylene)bis-(sulfanediyl) diacetic acid was also prepared The reaction of 3-formyl-substituted-1H-indole-2-carboxylates with substituted anilines by conventional and microwave methods gave Et 3-(N-aryliminomethyl)-5-halo-1H-indole-2-carboxylates. In a cyclocondensation reaction of these compounds with thiolactic acid or thioglycolic acid substituted indolylthiazolidinones were prepared Reaction of hydrazine hydrate with 3-formyl-substituted-1H-indole-2-carboxylates did not give the resp. hydrazones but directly led to the cyclized products substituted-3H-pyridazino[4,5-b]indol-4(5H)-ones, while a reaction with 2,4-dichlorophenylhydrazine yielded the uncyclized hydrazones. The chlorination of pyridazino[4,5-b]indol-4(5H)-one derivatives with POCI3 gave pyridazino[4,5-b]indoles, resp.; reaction of the latter compounds with morpholine gave 4-(substituted-5H-pyridazino[4,5-b]indol-4-yl)morpholines. Mannich reaction of pyridazino[4,5-b]indol-4(5H)-one with formaldehyde and N-ethylpiperazine gave 8-chloro-3-((4-ethylpiperazin-1-yl)methyl)-3H-pyridazino[4,5-b]indol-4(5H)-one. The microwave assistance of selected reactions has a profound effect on the reaction speed. The structures of the new compounds were confirmed by both anal. and spectral data. Some compounds were subjected to investigations concerning their antimicrobial, tranquilizing, and anticonvulsant activities.

There is still a lot of research devoted to this compound(SMILES：O=C(C(N1)=C(C=O)C2=C1C=CC(Cl)=C2)OCC)Formula: C12H10ClNO3, and with the development of science, more effects of this compound(43142-76-3) can be discovered.

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Synthetic Route of C6H8N2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Ethylpyrazine, is researched, Molecular C6H8N2, CAS is 13925-00-3, about Exploring microbial dynamics associated with flavours production during highland barley wine fermentation.

Highland barley wine (HBW) is a well-known grain wine in Qinghai-Tibet Plateau, China and is mainly fermented by local Qu (a traditional starter) with highland barley (Hordeum vulgare, Qingke (Tibetan hulless barley)), and the flavors profiles associated with microbiota succession during HBW fermentation are unrevealed. Hence, high-throughput sequencing (HTS) technol. was used to investigate the dynamic changes of microbial community for the duration of the fermentation In addition, metabolites were analyzed by gas chromatog.-mass spectrometry (GC-MS) and high performance liquid chromatog. (HPLC). A total of 66 volatile compounds and 7 organic acids were identified during the traditional brewing process. Results showed that the composition of microbiota varied over the fermentation process. The bacterial genera (relative abundance > 0.1%) decreased from 13 at 0 h to 4 encompassing Leuconostoc (13.53%) and Acetobacter (74.60%) after 48 h fermentation, while the structure of fungal community was more uniform in comparison with bacteria, as Rhizopus and Saccharomyces were predominant throughout the fermentation Furthermore, the correlations between microbiota and the detected compounds were also explored, which highlighted that three bacterial genera, including Acetobacter, Leuconostoc, Bacillus and one fungal genus Rhizopus were significantly correlated with main flavors compounds ([r] > 0.7, FDR < 0.01). To conclude, the detailed information provided by this study offer screening strategies of beneficial bacterial and fungal strains to improve the quality of HBW. If you want to learn more about this compound(2-Ethylpyrazine)Synthetic Route of C6H8N2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(13925-00-3).

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HPLC of Formula: 542-58-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Chloroethyl acetate, is researched, Molecular C4H7ClO2, CAS is 542-58-5, about Effects of polar β-substituents in the gas-phase pyrolysis of ethyl acetate esters. Author is Chuchani, Gabriel; Martin, Ignacio; Hernandez A., Jose A.; Rotinov, Alexandra; Fraile, German; Bigley, David B..

Kinetic data for the pyrolysis of AcOCH2CH2R (I; R = NMe2, OMe, SMe, Cl, F, CN) were obtained and discussed along with literature data for addnl. I. The effects of R fell into one of 3 classes. A linear correlation with σ constants was obtained for several -I electron-withdrawing groups. A small amount of anchimeric assistance was proposed in the pyrolysis of the I (R = SMe). The data were consistent with a transition state where the Cα-O bond polarization is the rate-determining process.

If you want to learn more about this compound(2-Chloroethyl acetate)HPLC of Formula: 542-58-5, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(542-58-5).

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The reaction with nitrous acid of certain derivatives of 4-aminopyridines, substituted in position 2 or 2 and 6. V. 4-Aminopicolinic acid and its amide and 2-cyano-4-aminopyridine》. Authors are Talik, Tadeusz; Plazek, Edwin.The article about the compound:4-Hydroxypicolinic acidcas:22468-26-4,SMILESS:O=C(O)C1=NC=CC(O)=C1).Reference of 4-Hydroxypicolinic acid. Through the article, more information about this compound (cas:22468-26-4) is conveyed.

cf. CA 53, 18954d. 4-Aminopyridine (I) derivatives with a CO2H, CONH2, or CN group in position 2 do not form stable diazonium compounds The 2-cyano derivative (II) of I, m. 145°, yield 92%, was prepared by heating 90 min. on steam bath 5 g. 4-aminopicolinic acid (III) amide (IV), m. 169°, 5 g. P2O5, 30 ml. POCl3, and 10 ml. PCl3, and crystallizing from water after addition of (NH4)2CO3. IV (63%) was prepared by reduction of 4-nitro-2-cyanopyridine N-oxide (V), m. 181°, with FeSO4 and aqueous NH3 solution V (62%) was obtained by boiling the resp. 2-iodo derivative with CuCN in pyridine. III m. 319° (decomposition) [260° as given by Graf (CA 31, 22149]. By action of HNO2 or gaseous N oxides on III, IV, or II in H2SO4 there was formed 4-hydroxypicolinic acid, m. 159°; amide m. 253°. An aqueous IV or II solution saturated with HCl reacted with NaNO2 to give 4-chloropicolinamide, m. 161°, 79% and 46%, resp.

If you want to learn more about this compound(4-Hydroxypicolinic acid)Reference of 4-Hydroxypicolinic acid, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(22468-26-4).

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloroethyl acetate( cas:542-58-5 ) is researched.Category: chiral-catalyst.Mastagli, Pierre; De Nanteuil, Michel published the article 《Reaction of titanium tetrachloride with ketone [ethylene ketals]》 about this compound( cas:542-58-5 ) in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques. Keywords: acetal titanium tetrachloride reaction; dioxolane titanium tetrachloride reaction; titanium tetrachloride acetal reaction. Let’s learn more about this compound (cas:542-58-5).

TiCl4 attacks cyclohexanone ethylene ketal (I, RR1 = cyclohexyl) (Ia) to give 2-chloroethyl 6-(1-cyclohexen-1-yl)caproate (II). This reaction was extended to several cyclic and linear ketone ethylene ketals. TiCl4 effects a kind of oxidation-reduction on 2 mols. of ethylene ketal leading to an ester and an alkene according to the general equation: I (R = R7CH2, R1 = R2) →R2CO2CH2CH2Cl (III) + R1CH:CR2CH2R1. The alc. part of III arises from the glycol forming the dioxolane ring. A cyclic ketone gives an olefinic ester. The mechanism of the reaction was not determined The exptl. results are summarized in the table; also IV gave 30% II by the same procedure. Thus, 0.5 mole TiCl4 was added dropwise to 1 mole ketal in CH2Cl2 with ice-bath cooling, kept overnight, hydrolyzed, washed with H2O, and distilled Characterization of the esters marked (a) in the table was made by reaction of the corresponding Et ester with ClCH2CH2OH in the presence of (PrO)4Ti; those marked (b) by esterification of the corresponding acid with ClCH2CH2OH; and those marked (c) by IR and N.M.R. anal. In the reaction of TiCl4 with acetone ethylene ketal, AcOCH2CH2Cl was obtained, but the formation of isobutene was not demonstrated since it forms high polymers in the presence of Lewis acids.

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SDS of cas: 22468-26-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-Hydroxypicolinic acid, is researched, Molecular C6H5NO3, CAS is 22468-26-4, about Discovery of potent c-MET inhibitors with new scaffold having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine headgroups.

Cellular mesenchymal-epithelial transition factor (c-MET) is closely linked to human malignancies, which makes it an important target for treatment of cancer. In this study, a series of 3-methoxy-N-phenylbenzamide derivatives, N-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl) benzamide derivatives and N1-(3-fluoro-4-methoxyphenyl)-N3-(4-fluorophenyl) malonamide derivatives were designed and synthesized, some of them were identified as c-MET inhibitors. Among these compounds with new scaffolds having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine head groups, compound 11c, 11i, 13b, 13h exhibited both potent inhibitory activities against c-MET and high anticancer activity against tested cancer cell lines in vitro. In addition, kinase selectivity assay further demonstrated that both 13b and 13h are potent and selective c-MET inhibitors. Mol. docking supported that they bound well to c-MET and VEGFR2, which demonstrates that they are potential c-MET RTK inhibitors for cancer therapy.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloroethyl acetate, is researched, Molecular C4H7ClO2, CAS is 542-58-5, about Electron capture detection and formation of negative ions in isomeric chlorinated ethyl acetates.Product Details of 542-58-5.

Gas chromatog. (GC)/electron capture detection and GC/neg. ion chem. ionization mass spectrometry were compared to each other to investigate ionic processes involved and to develop new derivatives for analyzing halogenated carboxylic acids which are, for example, of considerable importance in the environment. The results show that the response factors for isomeric chlorinated esters depend markedly on structural features and on neg. ion formation mechanisms and ion composition

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Name: 4-(Hydroxymethyl)-1,3-dioxolan-2-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(Hydroxymethyl)-1,3-dioxolan-2-one, is researched, Molecular C4H6O4, CAS is 931-40-8, about Heterogeneous synthesis of glycerol carbonate from glycerol and dimethyl carbonate catalyzed by LiCl/CaO. Author is Tang, Ying; Xue, Yu Ying; Li, Zhaoyi; Yan, Tianlan; Zhou, Rui; Zhang, Zhiping.

In this article, a CaO-based catalyst was prepared by impregnating chloride salts on CaO to develop a highly efficient heterogeneous catalyst for the synthesis of glycerol carbonate (GC) from glycerol and di-Me carbonate. LiCl/CaO exhibited a high catalytic activity under moderate reaction conditions. The effects of the LiCl loadings, the amount of catalyst and the calcination temperature on the catalytic activity were investigated. The highest yield of 94.19% glycerol carbonate was obtained at 65°C on CaO loaded with 10% LiCl after 1 h, and the catalyst had high stability in reusing work. SEM (SEM), X-ray diffraction (XRD), BET, CO2-TPD, XPS and thermalgravity (TG) were used to characterize the prepared catalyst. It was found that the high catalytic activity of CaO after modification with LiCl is associated with the structural aspects and the amount of basicity of the catalyst. The Li2O2 species, which is a strong basic site that is formed by the substitution of the Ca2+ in CaO lattice by Li+, has great activity for transesterification.

Here is a brief introduction to this compound(931-40-8)Name: 4-(Hydroxymethyl)-1,3-dioxolan-2-one, if you want to know about other compounds related to this compound(931-40-8), you can read my other articles.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 931-40-8, is researched, SMILESS is O=C1OCC(CO)O1, Molecular C4H6O4Journal, Liaoning Huagong called Preparation of catalyst from natural eggshell waste and its application in the synthesis of glycerol carbonate, Author is Wang, Sun-bo; Wang, Song; Li, San-xi, the main research direction is transesterification catalyst eggshell glycerol dimethyl carbonate dioxolanone preparation.Safety of 4-(Hydroxymethyl)-1,3-dioxolan-2-one.

Eggshell is a kind of waste with huge production Its main component is calcium carbonate, which can be used as the source of base catalyst, calcium oxide. Turning egg shell waste into base catalyst can turn waste into useful material and is in line with the concept of green chem. In this paper, the catalyst was prepared from waste egg shell, and its application in the synthesis of glycerol carbonate was explored. The property of prepared catalyst was investigated by FTIR, XRD, SEM and EDS. The investigation results indicated that the catalyst prepared from waste eggshells through adding dolomite and talcum powder by calcined at 1250°C for 4 h showed high catalytic ability. The prepared catalyst can be used in the synthesis of glycerol carbonate and has good activity. The optimal conditions for the synthesis of glycerol carbonate were determined as follows: the catalyst amount 5% (wt), the molar ratio of DMC to glycerol 3:1, the reaction temperature 80°C and the reaction time 2 h. Under above conditions, glycerol conversion rate reached 94.67%. However, the stability of the catalyst in the transesterification reaction is poor.

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HPLC of Formula: 931-40-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-(Hydroxymethyl)-1,3-dioxolan-2-one, is researched, Molecular C4H6O4, CAS is 931-40-8, about The role of impurities in the La2O3 catalyzed carboxylation of crude glycerol. Author is Razali, N. A.; Conte, M.; McGregor, J..

The direct carboxylation of crude glycerol, obtained as a byproduct of bio-diesel synthesis, with CO2 has been investigated over lanthanum oxide as a heterogeneous catalyst for the first time. Adiponitrile is employed as a dehydrating agent in order to shift the reaction equilibrium to the product side. The selectivity of the reaction towards glycerol carbonate when using crude glycerol is significantly reduced as compared to employing refined glycerol: 2.3% cf. 17% resp. Glycerol conversion, however remains approx. constant: 54% cf. 58%. In order to understand the role of the impurities present in crude glycerol, model systems consisting of refined glycerol and one or more of water, methanol, Me palmitate (as a model fatty acid Me ester), and sodium methoxide have been prepared and used as reaction media to systematically evaluate their effect. All of these impurities are seen to reduce the selectivity towards glycerol carbonate, instead favoring the formation of 4-(hydroxymethyl)oxazolidin-2-one, with the exception of methanol where no detrimental effect is observed and the measured selectivity increases slightly to ca. 22%. This effect is ascribed, in part, to improved mass transfer as a consequence of an increased solubility of carbon dioxide in the liquid media when methanol is present. Addnl., adiponitrile is observed to play a crucial role in the reaction mechanism beyond its simple role as a dehydrating agent. These results provide insights into the required purification steps for crude glycerol, and suggest the possibility of employing crude glycerol directly, and its use as a chem. feedstock; in both cases by minimizing costly separation and purification steps.

Here is a brief introduction to this compound(931-40-8)HPLC of Formula: 931-40-8, if you want to know about other compounds related to this compound(931-40-8), you can read my other articles.

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