Day: April 8, 2022

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Action of aluminum chloride on esters of polyatomic alcohols》. Authors are Dobryanskii, A. F.; Sivertsev, A. P..The article about the compound:2-Chloroethyl acetatecas:542-58-5,SMILESS:CC(OCCCl)=O).Recommanded Product: 2-Chloroethyl acetate. Through the article, more information about this compound (cas:542-58-5) is conveyed.

Reaction of AlCl3 with esters of polyat. alcs. leads to replacement of only part of the acyl groups by Cl; usually 1 acyl group is left and does not react with AlCl3. The following esters do not react with AlCl3: AcOCH2CH2Cl, BzOCH2CH2Cl, AcOCH2CHClCH2Cl, and AcOCH2C(CH2Cl)3. This is explainable by accumulation of neg. Cl atoms in such esters. In the course of the reaction AlCl3 is changed into ClAl(OAcyl)2. (CH2OAc)2 (60 g.) and AlCl3 (47.8 g.) 1 hr. at 150-60° gave 38.5 g. distillable oil, which on redistillation gave a fraction b. 142-8°, d2020 1.1295, identified as AcOCH2CH2Cl; the Al compound was best isolated by boiling 6 g. (CH2OAc)2 and 5 g. AlCl3 in 60 cc. CCl4 1 hr., followed by cooling and separation of the glassy layer, which was powdered in dry benzene and washed with Et2O; its analysis corresponded to C4H6O4AlCl. (CH2OBz)2 (20 g.) and 10.5 g. AlCl3 heated 1 hr. to 150-60° gave 108 g. oil, which on distillation gave a fraction b40 139-40°, d2020 1.1783, d420 1.1789, nD20 1.5283, identified as BzOCH2CH2Cl; heating 5.6 g. (CH2OBz)2 and 1.3 g. AlCl3 1 hr. at 150°, followed by cooling and separation of the crystals, gave the Al compound in pure state after washing as above, and its analysis corresponded to C14H10O4AlCl. Triacetin (219 g.), 44.5 g. AlCl3, and 323 g. CCl4 boiled 1 hr. gave 160 g. of oil which on distillation gave a fraction b20 125-30°, d2020 1.2018, d420 1.1996, nD20 1.4393, identified as diacetin chlorohydrin (diacetoxychloropropane); the AlCl3 under such conditions is transformed into C4H6O4AlCl, which was isolated by cooling a mixture of 10.8 g. triacetin and 6.6 g. AlCl3 which had been heated 1 hr. to 150°. Triacetin (108 g.) and 66.7 g. AlCl3 heated 1 hr. to 140-50° gave 104.4 g. oil, which on distillation gave a fraction b20 90-5°, b40 115-20°, d2020 1.2733, d420 1.2714, identified as 2,3-dichloropropyl acetate; refluxing 20 g. of this with 60 g. NaI and 300 cc. Me2CO, then heating in a sealed tube to 120°, gave the diiodide which with Zn gave 5.6 g. allyl acetate, b. 99-104°, d420 0.9941, nD20 1.4045. Pentaerythritol tetraacetate (I) (30.4 g.) and 7.3 g. AlCl3 heated 1 hr. at 160° gave 26.5 g. oil which on distillation gave a fraction b4.5 152-60°, d2020 1.2272, d420 1.225, nD20 1.4587, identified as pentaerythritol triacetate monochlorohydrin. I (30.4 g.) and 13.3 g. AlCl3 heated 1 hr. at 160° gave 26.7 g. oil which on distillation gave pentaerythritol diacetate dichlorohydrin, b6 146-8°, d2020 1.2620, d420 1.2600, nD20 1.4681. I (30.4 g.) and 26.7 g. AlCl3 heated 1 hr. to 150-60° gave pentaerythritol monoacetate trichlorohydrin, b8 126-7°, d2020 1.3111, d420 1.3057, nD20 1.4832. The Al salt which separated as a crust from the cooled mixture, after washing with Et2O analyzed well for C4H6O4AlCl.

I hope my short article helps more people learn about this compound(2-Chloroethyl acetate)Recommanded Product: 2-Chloroethyl acetate. Apart from the compound(542-58-5), you can read my other articles to know other related compounds.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A Ni3O-cluster based porous MOF for catalytic conversion of CO2 to cyclic carbonates, published in 2019-08-31, which mentions a compound: 931-40-8, mainly applied to nickel hydroxy aqua silanetriyltriisophthalato complex catalyst preparation crystal structure; gas adsorption nickel hydroxy aqua silanetriyltriisophthalato complex; cycloaddition catalyst nickel hydroxy aqua silanetriyltriisophthalato complex, Application In Synthesis of 4-(Hydroxymethyl)-1,3-dioxolan-2-one.

A novel Ni3O-based MOF, {[Ni3HL(μ3-OH)(H2O)2]•3(H2O)•DMA}n (1), was constructed based on an organosilicon hexacarboxylic acid linker of 5,5′,5”-(methylsilanetriyl)triisophthalic acid (H6L). In this structure, the deprotonated carboxylate groups assemble with trinuclear metal cluster nodes to give a 6-connected uninodal net. It possesses open channels and rich metal sites, and displays CO2 adsorption behavior. Further investigations indicate that the compound is catalytically effective for the cyclic carbonates by cycloaddition of CO2 to epoxides. Besides, the catalyst could be reused 5 times with no significant loss of catalytic activity and without structural deterioration.

I hope my short article helps more people learn about this compound(4-(Hydroxymethyl)-1,3-dioxolan-2-one)Application In Synthesis of 4-(Hydroxymethyl)-1,3-dioxolan-2-one. Apart from the compound(931-40-8), you can read my other articles to know other related compounds.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Solvent-free organocatalytic preparation of cyclic organic carbonates under scalable continuous flow conditions, published in 2019, which mentions a compound: 931-40-8, mainly applied to glycerol dimethyl carbonate transesterification solvent free organocatalyst, Formula: C4H6O4.

A solvent-free organocatalyzed process for the transesterification of DMC with 1,2-diols under scalable continuous flow conditions is presented. Process parameters, such as temperature, residence time, DMC/glycerol molar ratio and catalyst loading are optimized for the carbonation of bio-based glycerol using DBU as a model organocatalyst. The catalytic performance of DBU is next compared with other homogeneous organic superbases including the proton sponge, Verkade’s base, guanidines and phosphazenes. 2-Tert-butyl-1,1,3,3-tetramethylguanidine (Barton’s base) stands as the most efficient organocatalyst, providing glycerol carbonate at 87% selectivity and 94% conversion within 2 min of residence time at 1 mol% loading. Representative examples of PS-supported organic superbases of the amidine, guanidine and phosphazene-types are also considered as alternative heterogeneous catalysts. PS superbases typically enable up to 80 h of continuous operation with minor deactivation at elevated flow rates. The methodol. is amenable to a library of other 1,2-diols, including biomass-derived substrates. Depending on the unique structural features of both substrates and products, either online IR or online NMR anal. procedures are implemented for real-time qual. reaction monitoring. A final demonstrator showcases the transposition of the glycerol carbonation to a pilot-scale continuous flow reactor, affording the target cyclic carbonate with a 68.3 mol per day productivity (~8 kg per day).

I hope my short article helps more people learn about this compound(4-(Hydroxymethyl)-1,3-dioxolan-2-one)Formula: C4H6O4. Apart from the compound(931-40-8), you can read my other articles to know other related compounds.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: N5,N5-Dimethylpyridine-2,5-diamine( cas:39856-52-5 ) is researched.SDS of cas: 39856-52-5.Zhao, Hui; Hu, Xiaoxia; Cao, Kai; Zhang, Yue; Zhao, Kuantao; Tang, Chunlei; Feng, Bainian published the article 《Synthesis and SAR of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as potent and selective CDK4/6 inhibitors》 about this compound( cas:39856-52-5 ) in European Journal of Medicinal Chemistry. Keywords: pyrazoloquinazoline arylamino carboxamide preparation antitumor cyclin dependent kinase inhibitor; Anticancer; Cell cycle; Cyclin dependent kinase; Kinase selectivity. Let’s learn more about this compound (cas:39856-52-5).

CDK4/6 pathway is an attractive target for development of anti-cancer drugs. Herein, design and synthesis of a series of I (R1 = Ph; R2, R3 = H, Me; R4 = OEt, NH2, NHMe, NHEt) and I [R1 = 3-Me2NC6H4, 4-(piperazin-1-yl)phenyl, 2-pyridyl, etc.; R2 = R3 = H; R4 = NH2] as selective CDK4/6 inhibitors is reported. Applied with the optimizing strategy to the initial scaffold, it is found that the compound I [R1 = 5-(4-methylpiperazin-1-yl)pyridin-2-yl; R2 = R3 = H; R4 = NH2] is able to selectively inhibit CDK4 and CDK6 with IC50 values 0.01 and 0.026 μM, resp. This compound showed good anti-proliferative activity when tested in a panel of tumor cell lines with CDK4/6 related mechanism of action and worked much better than Ly2385219 which is a selective CDK4/6 inhibitor. This compound was also found to have favorable pharmacokinetic parameters.

I hope my short article helps more people learn about this compound(N5,N5-Dimethylpyridine-2,5-diamine)SDS of cas: 39856-52-5. Apart from the compound(39856-52-5), you can read my other articles to know other related compounds.

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Application In Synthesis of 4-(Hydroxymethyl)-1,3-dioxolan-2-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-(Hydroxymethyl)-1,3-dioxolan-2-one, is researched, Molecular C4H6O4, CAS is 931-40-8, about MgO nanoparticles confined in ZIF-8 as acid-base bifunctional catalysts for enhanced glycerol carbonate production from transesterification of glycerol and dimethyl carbonate. Author is Chang, Cheng-Wei; Gong, Zi-Jie; Huang, Nai-Chieh; Wang, Cheng-Yu; Yu, Wen-Yueh.

MgO-loaded ZIF-8 catalysts (MgO@ZIF-8) with various MgO loadings were prepared and characterized using at. absorption spectroscopy (AAS), powder X-ray diffraction (PXRD), Fourier-transform IR spectroscopy (FT-IR), N2 sorption isotherms, field-emission transmission electron microscopy (FE-TEM), and thermogravimetric anal. (TGA). Our results indicate that MgO nanoparticles could deposit onto the ZIF-8 surface with high atom efficiency while maintaining the ZIF-8 structure through a wet-impregnation and calcination process. It is suggested that the surface sites and microporosity of ZIF-8 support provide an adequate environment for the initial deposition of Mg precursor and subsequent growth of MgO nanoparticles through a nanoconfinement effect. MgO@ZIF-8 catalysts were tested for catalytic transesterification of glycerol and di-Me carbonate to yield glycerol carbonate. It is found that the 50 wt% MgO@ZIF-8 catalyst display an improved catalytic activity than those of MgO and ZIF-8. Furthermore, the MgO@ZIF-8 catalysts showed higher catalytic activities than their phys.-mixed counterparts, indicative of a synergistic effect between MgO and ZIF-8, which is explained by a proposed mechanism based on acid-base bifunctional sites on the surface.

I hope my short article helps more people learn about this compound(4-(Hydroxymethyl)-1,3-dioxolan-2-one)Application In Synthesis of 4-(Hydroxymethyl)-1,3-dioxolan-2-one. Apart from the compound(931-40-8), you can read my other articles to know other related compounds.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Moll, Annette; Hubner, Harald; Gmeiner, Peter; Troschutz, Reinhard researched the compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate( cas:43142-76-3 ).Recommanded Product: 43142-76-3.They published the article 《Phenylpiperazinylmethylindolecarboxylates and derivatives as selective D4-Ligands》 about this compound( cas:43142-76-3 ) in Bioorganic & Medicinal Chemistry. Keywords: phenylpiperazinylmethylindolecarboxylate derivative preparation structure activity dopamine D4 receptor binding. We’ll tell you more about this compound (cas:43142-76-3).

Novel phenylpiperazinylmethylindolecarboxylates were synthesized for evaluation as potential D4-ligands. Test compounds showed high affinity for the human dopamine D4 receptor and great selectivity over the other receptor subtypes. Intrinsic effects of indole derivatives, which indicated most promising binding properties, were investigated in a mitogenesis assay.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Halogenation in reactive solvents. II. The addition of halogen and acetoxyl to ethylene》. Authors are Weber, Fred C.; Hennion, G. F.; Vogt, R. R..The article about the compound:2-Chloroethyl acetatecas:542-58-5,SMILESS:CC(OCCCl)=O).SDS of cas: 542-58-5. Through the article, more information about this compound (cas:542-58-5) is conveyed.

cf. C. A. 32, 7405.8. ClCH2CH2OAc (I) and C2H4Cl2 (II) are the chief products when C2H4 is chlorinated in AcOH, Ac2O or AcOMe. In AcOH at 10-15° the mol. ratio of I/II is 0.522; addition of AcOH gives a ratio of 0.957; at 40-3° the ratio is 0.611. In Ac2O the ratio at room temperature is 0.195; with addition of AcONa, 0.770; in the 1st case AcCl is formed. In AcOMe the ratio is 0.476; AcOC2H2Cl3 and MeCl are also formed.

Here is just a brief introduction to this compound(542-58-5)SDS of cas: 542-58-5, more information about the compound(2-Chloroethyl acetate) is in the article, you can click the link below.

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Pereira, Priscila Vargas; Bravim, Danielle Goncalves; Grillo, Renata Pancini; Bertoli, Larissa Diirr; Osorio, Vanessa Moreira; da Silva Oliveira, Daniela; da Cruz Pedrozo Miguel, Maria Gabriela; Schwan, Rosane Freitas; de Assis Silva, Samuel; Coelho, Jussara Moreira; Bernardes, Patricia Campos published an article about the compound: 2-Ethylpyrazine( cas:13925-00-3,SMILESS:CCC1=NC=CN=C1 ).Formula: C6H8N2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:13925-00-3) through the article.

This study aimed to assess the microbial diversity in Coffea canephora grown in four different environments of Espirito Santo state, Brazil. Coffee cherries of two different altitudes (300 and 600 m) and two terrain aspects (Southeast-facing and Northwest-facing slopes) were processed by the dry method. Samples were collected during the drying/fermentation process. Microorganisms were counted, isolated, and identified by MALDI-TOF, followed by sequencing of the ribosomal region. Sugars and organic acids were quantified by HPLC and volatile compounds of the roasted coffees were evaluated by GC-MS. Bacteria population presented a significant number of isolates as well as higher counts during the drying/fermentation process with respect to the population of yeasts. The principal genera of microorganisms found were Bacillus, Pichia, Candida, and Meyerozyma. Meyerozyma guilliermondii was the most frequent yeast in all environments. On the other hand, Pichia kluyveri was found only in coffee cherries from the 600 m altitude. The highest concentration of acetic and succinic acids observed was 6.06 mg/g and 0.84 mg/g, resp. Sucrose concentrations ranged from 0.68 to 5.30 mg/g, fructose from 1.30 to 4.60 mg/g, and glucose from 0.24 to 1.25 mg/g. Thirty-six volatile compounds, belonging to the groups of pyrazines, alcs., aldehydes, ketones, and furans were identified in roasted coffee, with differences between altitude and terrain aspects. Information about microbial diversity is crucial to better understand the coffee quality and distinct characteristics of coffee produced in different environments. Graphic abstract: [graphic not available: see fulltext]

Here is just a brief introduction to this compound(13925-00-3)Formula: C6H8N2, more information about the compound(2-Ethylpyrazine) is in the article, you can click the link below.

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Application of 10466-61-2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Total synthesis of the post-translationally modified polyazole peptide antibiotic Goadsporin. Author is Dexter, Hannah L.; Williams, Huw E. L.; Lewis, William; Moody, Christopher J..

The structurally unique polyazole antibiotic goadsporin contains six heteroaromatic oxazole and thiazole rings integrated into a linear array of amino acids that also contains two dehydroalanine residues. An efficient total synthesis of goadsporin is reported in which the key steps are the use of rhodium(II)-catalyzed reactions of diazocarbonyl compounds to generate the four oxazole rings, which demonstrates the power of rhodium carbene chem. in organic chem. synthesis.

Here is just a brief introduction to this compound(10466-61-2)Application of 10466-61-2, more information about the compound(H-Leu-NH2.HCl) is in the article, you can click the link below.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Ethylpyrazine( cas:13925-00-3 ) is researched.Safety of 2-Ethylpyrazine.Hu, Hui; Liu, Hongzhi; Shi, Aimin; Liu, Li; Fauconnier, Marie Laure; Wang, Qiang published the article 《The effect of microwave pretreatment on micronutrient contents, oxidative stability and flavor quality of peanut oil》 about this compound( cas:13925-00-3 ) in Molecules. Keywords: peanut oil micronutrient oxidative stability flavor quality microwave pretreatment; Phytosterol; Pyrazines; Tocopherol; cold press; microwave pretreatment; oxidative stability; peanut. Let’s learn more about this compound (cas:13925-00-3).

The purpose of the present study is to investigate the changes in extraction yield, physicochem. properties, micronutrients content, oxidative stability and flavor quality of cold pressed peanut oil extracted from microwave (MW) treated seeds (0, 1, 2, 3, 4, 5 min, 700 W). The acid value and peroxide value of extracted oil from MW-treated peanuts were slightly increased but far below the limit in the Codex standard Compared with the untreated sample, a significant (p < 0.05) increase in extraction yield (by 33.75%), free phytosterols content (by 32.83%), free tocopherols content (by 51.36%) and induction period (by 168.93%) of oil extracted from 5 min MW-treated peanut were observed MW pretreatment formed pyrazines which contribute to improving the nutty and roasty flavor of oil. In conclusion, MW pretreatment is a feasible method to improve the oil extraction yield and obtain the cold pressed peanut oil with longer shelf life and better flavor. Here is just a brief introduction to this compound(13925-00-3)Safety of 2-Ethylpyrazine, more information about the compound(2-Ethylpyrazine) is in the article, you can click the link below.

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