Day: April 18, 2022

Computed Properties of C4H6O4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-(Hydroxymethyl)-1,3-dioxolan-2-one, is researched, Molecular C4H6O4, CAS is 931-40-8, about Recent progress in synthesis of glycerol carbonate and evaluation of its plasticizing properties. Author is de Caro, Pascale; Bandres, Matthieu; Urrutigoity, Martine; Cecutti, Christine; Thiebaud-Roux, Sophie.

The state of the art on the glycerol carbonate (GC) synthesis has been updated since the last published reviews in 2012, 2013, and 2016. Three types of reactions continue to be studied: glycerolysis of urea, transcarbonation of DMC, DEC, or cyclic carbonates with glycerol and reaction using CO2. Among these different routes, DMC and glycerol were selected as the rawmaterials for the GC synthesis in this work since the transcarbonation from these green reagents leads to high yields and selectivities, using mild conditions including a less energy consuming GC separation process. Catalytic conditions using Na2CO3 seem to be a good compromise to achieve a high yield of GC, leading to an easier purification step without GC distillation Mild temperatures for the reaction (73-78°C) as well as a low waste amount confirmed by the E-factor calculation, are in favor of controlled costs. Plasticizing properties of synthesized GC were compared to the behaviors of a com. plasticizer and natural dialkyl carbonates, for a colorless nail polish formulation. The resulting films subjected to mech. and thermal stresses (DMA and Persoz pendulum) showed the high plasticizing effect of GC toward nitrocellulose based films, probably due to hydrogen bond interactions between GC and nitrocellulose. The GC efficiency gives the possibility to decrease the content of the plasticizer in the formulation. Glycerol carbonate can be thus considered as a biobased ingredient abiding by the green chem. concepts, and safe enough to be used in an ecodesigned nail polish formulation.

The article 《Recent progress in synthesis of glycerol carbonate and evaluation of its plasticizing properties》 also mentions many details about this compound(931-40-8)Computed Properties of C4H6O4, you can pay attention to it, because details determine success or failure

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Recommanded Product: 931-40-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-(Hydroxymethyl)-1,3-dioxolan-2-one, is researched, Molecular C4H6O4, CAS is 931-40-8, about Lanthanum nanocluster/ZIF-8 for boosting catalytic CO2/glycerol conversion using MgCO3 as a dehydrating agent. Author is Hu, Chechia; Chang, Chien-Wei; Yoshida, Masaaki; Wang, Ke-Hsuan.

A lanthanum-modified zeolitic imidazolate framework (La/ZIF-8) was developed to produce glycerol carbonate using CO2 and glycerol as raw materials. La/ZIF-8 provides a high catalytic glycerol conversion efficiency owing to its surface-attached nanoclusters of La2O3, which can be viewed as La3+-O2- pairs that strengthen the Lewis basicity and acidity, and the large sp. surface area of ZIF-8. The catalytic glycerol conversion and the yield of glycerol carbonate were 46.5% and 35.3%, resp., using CH3CN as a dehydrating agent. With increase in the amount of CH3CN, the water mols. could react with CH3CN to reduce the selectivity. When an inorganic dehydrating agent, MgCO3, was used to phys. adsorb and remove water mols. in the reaction, the selectivity of the reaction could be increased to over 95%, which is the highest ever reported. Reaction kinetics anal. also revealed that the activation energy of using MgCO3 (5.4 kJ mol-1) as a dehydrating agent is lower than that using CH3CN (7.8 kJ mol-1). Moreover, the La/ZIF-8 could be recycled and reused at least three times with high catalytic performance. This study provides an effective material with dual Lewis basicity and acidity for CO2/glycerol conversion and significantly improves the catalytic performance using an inorganic dehydrating agent.

After consulting a lot of data, we found that this compound(931-40-8)Recommanded Product: 931-40-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Formula: C6H15ClN2O. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Retrosulfonamido peptide analogs. Synthesis and crystal conformation of Boc-Pro-Leu-Ψ(NHSO2)-Gly-NH2. Author is Zecchini, Giampiero Pagani; Paradisi, Mario Paglialunga; Torrini, Ines; Lucente, Gino; Gavuzzo, Enrico; Mazza, Fernando; Pochetti, Giorgio.

The title retrosulfonamido peptide I (Boc = Me3CO2C) was prepared by treating Boc-Pro-Leu-NH2 with (CF3CO2)2IPh, coupling the resulting gem-diamine II with ClSO2CH2CO2Me, and amidating the intermediate Me ester with NH3. I is the first example of a pseudopeptide incorporating the NH-SO2 junction. The crystal structure of I indicates that the ψ(NH-SO2) induces a cisoidal (gauche) conformation which induces a backbone folding and prevents the H-bonded β-turn found in the parent peptide.

After consulting a lot of data, we found that this compound(10466-61-2)Formula: C6H15ClN2O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral Catalysts,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase, published in 2011, which mentions a compound: 39856-52-5, mainly applied to imidazo pyridine derivative preparation structure IGF1R tyrosine kinase antitumor, Safety of N5,N5-Dimethylpyridine-2,5-diamine.

We disclose a novel series of insulin-like growth factor-1 receptor kinase inhibitors based on the 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridine scaffold. The influence on the inhibitory activity of substitution on the imidazopyridine and at the C5 position of the pyrimidine is discussed. In the course of this optimization, we discovered a potent and selective inhibitor with suitable pharmacokinetics for oral administration.

After consulting a lot of data, we found that this compound(39856-52-5)Safety of N5,N5-Dimethylpyridine-2,5-diamine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral Catalysts,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 931-40-8, is researched, Molecular C4H6O4, about Metal-Organic-Framework-Derived Hollow N-Doped Porous Carbon with Ultrahigh Concentrations of Single Zn Atoms for Efficient Carbon Dioxide Conversion, the main research direction is MOF derived nitrogen carbon zinc catalytic carbon dioxide fixation; CO2 cycloaddition; carbon materials; metal-organic frameworks; photothermal effect; single-atom catalysis.Recommanded Product: 4-(Hydroxymethyl)-1,3-dioxolan-2-one.

The development of efficient and low energy-consumption catalysts for CO2 conversion is desired, yet remains a great challenge. Herein, a class of novel hollow porous carbons (HPC), featuring well dispersed dopants of nitrogen and single Zn atoms, have been fabricated, based on the templated growth of a hollow metal-organic framework precursor, followed by pyrolysis. The optimized HPC-800 achieves efficient catalytic CO2 cycloaddition with epoxides, under light irradiation, at ambient temperature, by taking advantage of an ultrahigh loading of (11.3 wt %) single-atom Zn and uniform N active sites, high-efficiency photothermal conversion as well as the hierarchical pores in the carbon shell. As far as we know, this is the first report on the integration of the photothermal effect of carbon-based materials with single metal atoms for catalytic CO2 fixation.

After consulting a lot of data, we found that this compound(931-40-8)Recommanded Product: 4-(Hydroxymethyl)-1,3-dioxolan-2-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Preparation and hydrolysis of esters derived from the substituted aliphatic alcohols》. Authors are Drushel, W. A.; Bancroft, G. R..The article about the compound:2-Chloroethyl acetatecas:542-58-5,SMILESS:CC(OCCCl)=O).Product Details of 542-58-5. Through the article, more information about this compound (cas:542-58-5) is conveyed.

AcOCHCIMe, AcOCHMeOEt, and EtCO2CHMeCl, which were prepared by methods previously recorded in the chem. literature, were all immediately decomposed when dissolved in 0.1 N HCl. Their reaction velocities are, therefore, not measurable. AcH formed one of the hydrolysis products in the case of all 3 esters. AcOCH2CH2OH (A), b. 187-9°, was prepared by heating under reflux equimol, amounts of (CH2OH)2 and glacial AcOH together with twice the theoretical amount of anhydrous CuSO4. AcOCH2CH2OMe (B). b. 144-5°, was formed by treating the corresponding alc. with AcCl. AcOCH2CH2OEt (C), b. 157-8°, was prepared from the corresponding ale. (which was formed by Polomaa’s method (Ber. 35, 3300(1902)) or by heating CH2BrCH2OAc (D) with an equimol. amount of EtONa. CH2ClCH2OAc (E), b. 143-5° was obtained by Henry’s method (Ber. 7, 70(1874)). A mixture of equimol. quantities of (CH2Br)2 and fused AcOK when heated on the H2O bath for 18 hrs. gave rise not to (A) but to (CH2OAc)2. Hydrolysis of (A), (B). (C), (D), (E) by means of 0.1 N HCl was effected at 25, 35 and 45°, and the velocity constants and temperature coefficients determined The subsitution of -OH, -OR, or halogen in place of the β-H hi the alkyl radical of AcOEt, causes retardation in the rate of hydrolysis. The -OH, -OEt, and Cl groups all produce practically the same degree of retardation. EtO causes a slightly greater retardation than does the OMe group, Br- causes less of ft retardation than does the Cl-radical. The temperature coefficients of the above esters varied from 2.3 to a.j for an increase of 10°. The substitution of Br bad ft lowering effect upon the temp, coefficient

After consulting a lot of data, we found that this compound(542-58-5)Product Details of 542-58-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Guanhao; Yang, Jingyi; Xu, Xinru researched the compound: 4-(Hydroxymethyl)-1,3-dioxolan-2-one( cas:931-40-8 ).Name: 4-(Hydroxymethyl)-1,3-dioxolan-2-one.They published the article 《Synthesis of hydrotalcite-type mixed oxide catalysts from waste steel slag for transesterification of glycerol and dimethyl carbonate》 about this compound( cas:931-40-8 ) in Scientific Reports. Keywords: waste steel slag hydrotalcite transesterification catalyst glycerol dimethyl carbonate. We’ll tell you more about this compound (cas:931-40-8).

The mixed metal oxides S-CaMgAl MO prepared by acidolysis, coprecipitation and calcination under different temperatures from S95 steel slag of Shanghai Baosteel Co., Ltd. were used to catalyze the transesterification of di-Me carbonate (DMC) and glycerol for synthesizing glycerol carbonate (GC). The catalysts were characterized by EDS, XRD, FT-IR, SEM, CO2-TPD and nitrogen adsorption-desorption isotherms. S-CaMgAl MO calcined at 600°C had excellent catalytic performance due to the large pore size and proper alkalinity The effects of reaction temperature, reaction time and the amount of catalyst on transesterification were investigated to obtain the optimal reaction conditions. The glycerol carbonate yield reached 96.2% and the glycerol conversion was 98.3% under the condition of 3 wt% catalyst, 1:3 molar ratio of glycerol and DMC, 75° reaction temperature and 90 min reaction time. In addition, the GC yield and glycerol conversion still achieved above 90% after five cycles of S-CaMgAl MO.

After consulting a lot of data, we found that this compound(931-40-8)Name: 4-(Hydroxymethyl)-1,3-dioxolan-2-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Cleavage of cyclic acetals by acyl halides. Reaction mechanism》. Authors are Atavin, A. S.; Trofimov, B. A.; Orlova, S. E.; Keiko, V. V..The article about the compound:2-Chloroethyl acetatecas:542-58-5,SMILESS:CC(OCCCl)=O).Application of 542-58-5. Through the article, more information about this compound (cas:542-58-5) is conveyed.

A mixture of 25.5 g. 2,4-dimethyl-1,3-dioxolane (36% trans, 64% cis), 0.1 g. ZnCl2, and 19.6 g. AcC1 (I) was held at 50° 3 hrs. and distilled to yielding, in addition to starting materials, 2.2 g. resinous residue, and two fractions corresponding to β-chloroisopropyl acetate (II) and propylene glycol diacetate (III). To remove traces of an intermediate α-chloro ether, III was extracted with water, dried with Na2SO4, and redistilled The yield, b.p., n20D and d20 were resp.: II, 32.5%, b33 66-7°, 1.4223, 1.0914; III, 18.3%, b25 90-3°, 1.4170, 1.0559. Analogously, reaction of I with 2-methyl-1,3-dioxolane (IV) yielded β-chloroethyl acetate (V) and ethylene glycol diacetate (VI). Reaction of I with 2,4-dimethyl-1,3-dioxane yielded 1,3-butanediol diacetate (VII) and a mixture (VIII) of the acetates of 1-chloro-3-butanol and 3-chloro-1-butanol. The b.p., n20D and d20 were resp.: V, b10 41°, 1.4220, 1.1472; VI, b20 87°, 1.4170, 1.1063; VII, b7 82°, 1.4202, 1.0399; VIII b7, 57°, 1.4299, 1.0666. A mixture of 22 g. IV with 0.2 g. AlCl3 and 46.2 g. BzBr was agitated 11 hrs. at 70-100°, and vacuum distilled One fraction (b4 120-30°) afforded, after removal of BzOH crystals and redistillation, 14.5 g. β-bromoethyl benzoate (IX). A second fraction (b2 180-95°), after recrystallization from EtOH, afforded 13 g. of ethylene glycol dibenzoate, m. 69°, b2 180-3°. The tarry distillation residue weighed 8.9 g. Similarly, a mixture of 36.5 g. diisopropyl acetal, 19.6 g. I, and 0.15 g. ZnCl2 on fractionation yielded 8.2 g. of isopropyl acetate (X), along with iso-PrCl and a residue (13.7 g.). The b.p., n20D, and d20 of IX and X are, resp.: IX, b2 102-5°, 1.5478, 1.4308; X, b720 85-6°, 1.3760, 0.8689. To investigate proposed mechanisms involving chloro ether and ester intermediates, some of these possible intermediates were independently prepared Saturation of 10 g. vinyl acetate with HCl at 3-5°, and distillation of the product yielded 86% α-chloroethyl acetate, b718 115-18°, n20D 1.4055, d20 1.1016. I (39 g.) was added over 2.5 hrs. to an agitated mixture of 44 g. monovinyl ether of ethylene glycol in 100 ml. Et3N. After separation of the amine hydrochloride distillation yielded 70.4% vinyl β-acetoxyethyl ether (XI), b35 64-6°, n20D 1.4259, d20 1.0060. Saturation of XI with dry HCl at 0° and fractionation yielded 72% 1-(α-chloroethoxy)-2-acetoxyethane (XII), b15 84°, n20D 1.4348, d20 1.1281. When 16 g. XII was treated with 0.1 g. ZnCl2 and heated to 37°, the mixture evolved HCl and darkened. Fractionation yielded 6 g. V, 2.6 g. VI, and 1.9 g. tar. The decomposition of XII is consistent with the hypothesis that XII is a reaction intermediate in the reaction of I with IV. Since these reactions also proceed non-catalytically the catalyst role is regarded as accelerating the removal of the halogen from the acyl chloride (e.g. to form Ac+[ZnCl3-]), with subsequent nucleophilic attack by the acetal O on the pos. charged acylium carbon. If the resulting complex expels a proton, a vinyl ether is formed, whose polymerization explains the tars.

After consulting a lot of data, we found that this compound(542-58-5)Application of 542-58-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 931-40-8, is researched, SMILESS is O=C1OCC(CO)O1, Molecular C4H6O4Journal, ACS Omega called Enhanced Productivity in Glycerol Carbonate Synthesis under Continuous Flow Conditions: Combination of Immobilized Lipases from Porcine Pancreas and Candida antarctica (CALB) on Epoxy Resins, Author is do Nascimento, Marcelo A.; Gotardo, Larissa E.; Leao, Raquel A. C.; de Castro, Aline M.; de Souza, Rodrigo O. M. A.; Itabaiana, Ivaldo, the main research direction is glycerol carbonate immobilized lipase porcine pancreas CALB epoxy resin.Name: 4-(Hydroxymethyl)-1,3-dioxolan-2-one.

Glyceryl carbonate (GC) is one the most important value-added products from glycerol that has gained prominence during the recent years mainly due to its attractive physicochem. properties and the wide range of applications. As an alternative to produce GC under green environment, we have applied in this work a combination of two new biocatalysts containing lipases from porcine pancreas (PPL) and Candida antarctica (CaLB) immobilized on epoxy resins for GC production via integrated reaction between triacylglycerol and di-Me carbonate (DMC) both under batch and packed bed reactors. Under continuous flow conditions, the combination 1:1 (weight/weight) of the home-made immobilized biocatalysts were able to lead to complete conversion of GC with > 99% selectivity against 88% demonstrated by the com. preparation Novozym 435. The new continuous flow biocatalytic system demonstrated a final productivity of 16 x10-2 g of GC.h-1. U-1 of biocatalyst.

After consulting a lot of data, we found that this compound(931-40-8)Name: 4-(Hydroxymethyl)-1,3-dioxolan-2-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloroethyl acetate, is researched, Molecular C4H7ClO2, CAS is 542-58-5, about Syntheses and reactions of functional polymers. LXXXII. Aminolyses of alkyl acetates containing electron-withdrawing substituents in leaving groups.COA of Formula: C4H7ClO2.

The aminolysis of alkyl acetates AcOCH2R (R = Me, CH2Cl, CH2CN, CCl3) was examined The relative rates in DMF were 1, 37, 87, 2700, resp. Similar relative reactivities were observed in the reaction with H2N(CH2)2NH2 in DMF or with H2N (CH2)2OH in dioxane. The ρ values in all cases were > 3 in Taft’s quantum log (k/k0) = ρ * σ*. A linear relation of log k/k0 with νCO was observed Inductive effects played an important role in the activation of the alkyl acetates. The mechanism was also discussed.

After consulting a lot of data, we found that this compound(542-58-5)COA of Formula: C4H7ClO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare