Electric Literature of 1806-29-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 1806-29-7, C12H10O2. A document type is Article, introducing its new discovery.
Rhodium catalysed asymmetric hydroformylation with chiral diphosphite ligands
Chiral diphosphites have been synthesised starting from 1,2:5,6-diisopropylidene-D-mannitol, L-alpha,alpha,alpha,alpha,-tetramethyla-1,3-dioxolan-4,5-dimethanol and L-diethyltertrate. The diols react in moderate to good yields with 2,2′-bisphenoxyphosphorus chloride and 4,4’6,6′,-tetra-t-butyl-2,2′-bisphenoxyphosphorus chloride (32-92%) to the corresponding chiral diphosphites. The compounds all exhibit C2 symmetry and have been used as ligands in the rhodium catalysed asymmetric hydroformylation of styrene. The catalytic activity of the diphosphites strongly depends on the bulkynes of the ligand. With a bulky ligand enantiomeric excesses up till 20% have been obtained under mild reaction conditions (25-40C, 40 bar syngas). It was found that both enantiomeric excess and regioselectivity to the branched aldehyde strongly depend on the hydroformylation reaction conditions.
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Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare