With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.173035-10-4,1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.
General procedure: The appropriate salt 2 (52.44 mmol) was added to a solution of potassium tert-butoxide (6.72 g, 59.93 mmol) in THF (30 mL). Thereaction mixture was stirred at 25 C for 15 min and then filtered.The filtrate was added to a solution of complex 3 (30.00 g,37.46 mmol) in toluene (900 mL). The reaction mixture wasstirred at 80 C for 1.5 h, cooled to 25 C, and filtered. The solvent was removed in vacuo. The red-brown precipitate wassuspended in hexane (500 mL). Then the precipitate was filtered, successively washed with hexane and methanol, and driedin vacuo at 45 C.
As the paragraph descriping shows that 173035-10-4 is playing an increasingly important role.
Reference£º
Article; Shcheglova; Kolesnik; Ashirov; Krasnokutskaya; Russian Chemical Bulletin; vol. 65; 2; (2016); p. 490 – 497; Izv. Akad. Nauk, Ser. Khim.; vol. 65; 2; (2016); p. 490 – 497,8;,
Chiral Catalysts
Chiral catalysts – SlideShare