Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Trost, Barry M., once mentioned the application of 1121-22-8, Name is trans-Cyclohexane-1,2-diamine, molecular formula is C6H14N2, molecular weight is 114.19, MDL number is MFCD00063747, category is chiral-catalyst. Now introduce a scientific discovery about this category, SDS of cas: 1121-22-8.
Design and exploration of new intermediates for chemo-, regio-, and stereoselective cycloadditions remain a formidable challenge in modern organic synthesis. Compared to the well-developed 1,3-dipolar cycloadditions, Pd-catalyzed1,4-dipolar cycloadditions are generally limited to specialized substrates due to the inherent nature of the thermodynamically driven intramolecular transformations and undesired isomerizations. Herein, we demonstrate the use of ligated palladium catalysts to control and modulate the intermolecular reactivity of aliphatic 1,4-dipoles, enabling two distinctive cycloaddition pathways with a broad scope of acceptors. This atom-economic process also features an eco-friendly in situ deprotonation strategy to generate the corresponding active palladium-mediated dipoles. Overall, a diverse array of chiral 6-membered rings and spiro [2.4] heptanes were prepared in high yield and selectivity. In addition, an unexpected property of cyano-stabilized carbanions was discovered and investigated, which can be useful in designing and predicting future transformations.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 1121-22-8, SDS of cas: 1121-22-8.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare