In an article, author is Baydas, Yasemin, once mentioned the application of 57090-45-6, Recommanded Product: (R)-(-)-3-Chloro-1,2-propanediol, Name is (R)-(-)-3-Chloro-1,2-propanediol, molecular formula is C3H7ClO2, molecular weight is 110.5395, MDL number is MFCD00135169, category is chiral-catalyst. Now introduce a scientific discovery about this category.
Chiral heterocyclic secondary alcohols have received much attention due to their widespread use in pharmaceutical intermediates. In this study, Lactobacillus kefiri P2 biocatalysts isolated from traditional dairy products, were used to catalyze the asymmetric reduction of prochiral ketones to chiral secondary alcohols. Secondary chiral carbinols were obtained by asymmetric bioreduction of different prochiral substrates with results up to>99% enantiomeric excess (ee). (R)-1-(benzofuran-2-yl)ethanol 5a, which can be used in the synthesis of pharmaceuticals such as bufuralols potent nonselective beta-blockers antagonists, Amiodarone (cardiac anti-arrhythmic), and Benziodarone (coronary vasodilator), was produced in gram-scale, high yield and enantiomerically pure form using L. kefiri P2 biocatalysts. The gram-scale production was carried out, and 9.70 g of (R)-5a in enantiomerically pure form was obtained in 96% yield. Also, production of (R)-5a in terms of yield and gram scale through catalytic asymmetric reduction using the biocatalyst was the highest report so far. This is a cost-effective, clean and eco-friendly process for the preparation of chiral secondary alcohols compared to chemical processes. From an environmental and economic perspective, this biocatalytic method has great application potential, making it a green and sustainable way of synthesis.
If you are interested in 57090-45-6, you can contact me at any time and look forward to more communication. Recommanded Product: (R)-(-)-3-Chloro-1,2-propanediol.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare