With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.
A vial was charged with [Au(SMe2)Cl] (53mg, 190mumol, 1.06 equiv.), IPr.HCl (76mg, 179mumol, 1 equiv.) and KOtBu (31mg, 277mumol, 1.5 equiv.) in THF (0.5mL), under air. The mixture was stirred for 2h at room temperature. KOtBu (62mg, 553mumol, 3 equiv.) was then added followed by toluene (0.5mL). After 3h at room temperature, the crude mixture was then filtered through Celite and washed with additional THF. Water (0.1mL) was added to the solution and the solution was stirred for an additional 15min. THF was then removed under vacuum. More water was added to the white, cloudy suspension and the product was vigorously stirred for a few minutes. It was left to settle for 10min, collected using a Buchner funnel and washed with hexane. It was then dried under vacuum for several days to produce a white microcrystalline solid.
The synthetic route of 250285-32-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Nahra, Fady; Patrick, Scott R.; Collado, Alba; Nolan, Steven P.; Polyhedron; vol. 84; (2014); p. 59 – 62;,
Chiral Catalysts
Chiral catalysts – SlideShare