Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Safety of (R)-(-)-3-Chloro-1,2-propanediol, 57090-45-6, Name is (R)-(-)-3-Chloro-1,2-propanediol, molecular formula is C3H7ClO2, belongs to chiral-catalyst compound. In a document, author is Tanaka, Shinji, introduce the new discover.
A catalytic system for asymmetric intramolecular dehydrative allylation was established, which was developed from a dehydrative-alcohol-allylation catalyst, CpRu-2-quinolinecarboxylic acid. A CpRu complex of Cl-Naph-PyCOOH, a chiral pyridine-2-carboxylic acid bearing a 2-chloronaphthalen-1-yl group at the C (6) position and a methyl group at the C (5) position, was designed by investigating the ligand structure-reactivity relationship in the intramolecular dehydrative allylation of alcohols. The catalyst showed high reactivity and enantioselectivity toward allylic cyclization from allylic alcohols with nucleophilic moieties, such as protic hydroxy, acylamino, and carboxyl groups, affording a variety of corresponding chiral cyclic ethers, amines, and lactones. Aprotic pyrroles were also utilized as C-nucleophiles. Furthermore, unstable hemiacetal, hemiaminal, or aminal formed in situ were transformed to the corresponding protected chiral 1,2- or 1,3-O,O, O,N, N,O, or N,N bifunctional compounds by the catalyst. The catalytic activity toward allylic alcohol is based on the soft ruthenium/hard Bronsted acid synergetic effect in which a double bond interacts with ruthenium and a hydrogen bond forms between protons and the hydroxy group. Additionally, the chloro group at naphthalene plays a key role in forming a halogen bond with nucleophilic moieties. This interaction allows easier formation of the transition state of oxidative addition, resulting in high enantioselectivity caused by performing only one major catalytic cycle. This account summarizes these results and provides insight into the reaction mechanisms.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 57090-45-6. Safety of (R)-(-)-3-Chloro-1,2-propanediol.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare