A common heterocyclic compound, the chiral-catalyst compound, name is 1,4,7,10,13-Pentaoxacyclopentadecane,cas is 33100-27-5, mainly used in chemical industry, its synthesis route is as follows.,33100-27-5
EXAMPLE 3 Production of 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-methylsulfenyl-5-(1-oxy-pyridin-3-ylmethylamino)pyrazole-3-carbonitrile (Compound No. 14) In 10 ml of N,N-dimethylformamide was suspended 0.1 g of 60percent sodium hydride, and 1 g of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole-3-carbonitrile was gradually added thereto. After 20 minutes of stirring at room temperature, 3 drops of 15-crown-5-ether and then 0.3 g of 3-chloromethylpyridine-1-oxide were added thereto, followed by stirring at room temperature. After standing over one night, water and ethyl acetate were added thereto and the mixture was neutralized by 1N hydrochloric acid. After liquid separation, the organic layer was washed with saturated saline and then dried over anhydrous sodium sulfate. The residue was purified by a silica gel column chromatography to obtain 0.9 g of the compound (No. 14) described in the following Table 1.
As the rapid development of chemical substances, we look forward to future research findings about 33100-27-5
Reference£º
Patent; MITSUBISHI CHEMICAL CORPORATION; US2003/60471; (2003); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare