Final Thoughts on Chemistry for (1R,2S)-(−)-2-Amino-1,2-diphenylethanol

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Direct experimental evidence for the priority of flexible ligand skeleton in asymmetric Friedel-Crafts alkylation was obtained through XRD analysis of flexible ligand/ZnCl2 complex, as well as synthesis of dihydroacridine-linked bis(oxazoline) ligands with planar rigid scaffold. A transition state model without NH phi interaction was proposed for the rigid ligands to interpret the inversion of absolute configuration.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare