1121-22-8, trans-Cyclohexane-1,2-diamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a pyrex vial 4-chloro-2-methylphthalazin-l (2H)-one (300 mg, 1.54 mmol), RuPhos 3rd generation precatalyst (121 mg, 0.154 mmol), and sodium tert-butoxide (444 mg, 4.62 mmol) were added, the vial was sealed, and the atmosphere evacuated and purged with N2 (3X). (+/-)-Transcyclohexanediamine (370 mu, 3.08 mmol) in toluene (6 mL) was then added, and the reaction was heated at 70 C overnight. The crude reaction was concentrated in vacuo, deposited onto silica gel with aid of methanol, and purified by silica gel chromatography using 85% 90: 10:1 dichloromethane :methanol:NH40H as eluent. The product fractions were concentrated and lyophilized to provide the title compound (191 mg, 45% yield). LCMS M/Z (M+H) 273.
1121-22-8, The synthetic route of 1121-22-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; CRAWFORD, Terry; DUPLESSIS, Martin; GOOD, Andrew, Charles; LEBLANC, Yves; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; (179 pag.)WO2016/36954; (2016); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare