1121-22-8, trans-Cyclohexane-1,2-diamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: 2.6.2 ;(alphaR,3aR,7aR)-rel-2-(1-hydroxyethyl)-3a,4,5,6,7,7a-Hexahydro-1H-benzimidazole (2); In a typical catalytic reaction, 1.1 mmol of glycerol dissolved in6.0 ml of water were introduced in a Schlenk tube equipped withan argon inlet and deaerated by bubbling argon through a needlefor 15 min. After addition of the catalyst (0.011 mmol) and of thecocatalyst (0.11 mmol), the reaction vessel was closed with a serumcap serumcap and the amine (1.1 mmol) was added by a micro-syringe; thenthe vessel was heated under vigorous stirring to the chosen reactiontemperature in a thermostatted oil bath. After the desired reactiontime, the catalytic reaction was stopped by cooling the Schlenk tubeto r.t. and letting air in under stirring..IR (KBr) 3447, 3246, 3175, 1647 cm-1. 1H NMR (500 MHz, CDCl3, 25 C): delta 5.57 (1H, bs, NH), 3.62 (1H, q, J = 6.92 Hz, CHOH), 3.04-2.98 (1H, m, H-7a), 2.54-2.47 (1H, m, H-3a), 1.88 (1H, bs, OH), 1.83-1.65 (4H, m, H-4, H-5, H-6, H-7), 1.40-1.15 (7H, d, J = 6.92 Hz, CH3, m, H-4, H-5, H-6, H-7) ppm. 13C NMR (125.68 MHz, CDCl3, 25 C): delta 173.0 (s, C-2), 58.5 (d, C-7a), 58.3 (d, C-3a), 55.1 (d, CHOH), 31.3 (t, C-7), 30.4 (t, C-4), 24.6 (t, C-6), 23.7 (t, C-5), 18.1 (q, CH3) ppm (
1121-22-8, As the paragraph descriping shows that 1121-22-8 is playing an increasingly important role.
Reference£º
Article; Crotti, Corrado; Farnetti, Erica; Licen, Sabina; Barbieri, Pierluigi; Pitacco, Giuliana; Journal of Molecular Catalysis A: Chemical; vol. 382; (2014); p. 64 – 70;,
Chiral Catalysts
Chiral catalysts – SlideShare