With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4488-22-6,[1,1′-Binaphthalene]-2,2′-diamine,as a common compound, the synthetic route is as follows.
To a solution of BINAM (100 mg, 0.35 mmol) and pyridine (85 mL, 1.05 mmol) inacetnitrile (3.5 mL) was added p-toluenesulfonylchloride (73 mg, 0.38 mmol), and the mixture was refluxed for 12 h. After cooling to ambient temperature, the reaction was quenched with brine (10 mL) and extracted with EtOAc (15 mL¡Á 3). The combined organic extracts were dried (MgSO4) and concentrated. The residue was purifiedby column chromatography on silica gel using hexane-EtOAc as the eluent, to give A-2; yield: 119 mg (78%)., 4488-22-6
The synthetic route of 4488-22-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Zhang, Yu; Mao, Mao; Ji, Yi-Gang; Zhu, Jie; Wu, Lei; Tetrahedron Letters; vol. 57; 3; (2016); p. 329 – 332;,
Chiral Catalysts
Chiral catalysts – SlideShare