With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.602-09-5,[1,1′-Binaphthalene]-2,2′-diol,as a common compound, the synthetic route is as follows.
602-09-5, In a 500 mL four-necked flask,Add (¡À)-1,1′-link (2-naphthol) 28.6 g (0.1 mol),50g toluene,4g of N,N-dimethylacetamide,1.9 g of potassium carbonate and ethylene carbonate 22 g (0.25 mol).After 6 hours of reaction at 100oC,The content of (¡À) -2,2′-bis- (2-hydroxyethoxy) -1,1′-binaphthyl was less than 0.1%Stop the reaction.Adding toluene,Water to neutral,Cooling precipitates solids,After vacuum drying for 12 hours,31.8 g of (¡À) -2,2′-bis- (2-hydroxyethoxy) -1,1′-binaphthyl was obtained,The yield is 84.9%.High-performance liquid chromatography (HPLC) analysis of 99.2% purity,Loss on drying at 120 degrees is 0.10%
As the paragraph descriping shows that 602-09-5 is playing an increasingly important role.
Reference£º
Patent; Jiangsu Yong Xing Chemical Co., Ltd.; Xu Weihua; Su Bo; Lu Guoyuan; Zhang Qiang; (6 pag.)CN107176905; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare