With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.673-06-3,D-Phenylalanine,as a common compound, the synthetic route is as follows.
673-06-3, To the suspension of D-phenylalanine (1 g, 6 mmol) in 25 mL water at room temperature, NaOH (0.72 g, 18 mmol) and p-toluenesulfonyl chloride (1.37 g, 7.2 mmol) were added. The mixture was stirred at 60 C for 6 h. Acid base washed method was used to collect product from the reaction mixture. 3MConc. HCl and EtOAc were added to the reaction mixture.The starting material (D-phenylalanine) was protonated and shifted to the aqueous phase and product was shifted to the organic phase at pH = 1. Product was then deprotonated by adding by adding 2M NaOH aqueous solution to the organic phase and it was come back to the aqueous phase at pH =11-12. At the end, product was protonated by adding 3M HCland was collected in organic phase. The organic phase is washed with brine, dried with MgSO4 and product was obtained (1.80 g, 95 %) by evaporating the solvent.
The synthetic route of 673-06-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ali, Zulfiqar; Gilani, Syeda Rubina; Hussain, Habib; Hussain, Imdad; Asian Journal of Chemistry; vol. 26; 20; (2014); p. 6733 – 6736;,
Chiral Catalysts
Chiral catalysts – SlideShare