Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 10466-61-2, is researched, SMILESS is N[C@@H](CC(C)C)C(N)=O.[H]Cl, Molecular C6H15ClN2OJournal, Article, Research Support, Non-U.S. Gov’t, International Journal of Peptide & Protein Research called Protease-catalyzed synthesis of Leu-enkephalin in a solvent-free system, Author is Klein, Jens Uwe; Cerovsky, Vaclav, the main research direction is enzymic peptide coupling leucine enkephalin; protease catalyst peptide coupling leucine enkephalin.Application of 10466-61-2.
The total enzymic synthesis of a model peptide Leu-enkephalin on a preparative scale was accomplished in the so-called solvent-free system. The syntheses were carried out in a rotary glass homogenizer by admixing solid reactants with native proteases and Na2CO3·10H2O. The most feasible way leading to biol. active Leu-enkephalin, was based on the strategy of 2 + (1 + 2) condensation catalyzed by α-chymotrypsin, thermolysin and papain for the final segment coupling. Subtilisin was used for the ester hydrolysis of peptide intermediates. Alternative strategies as well as the influence of several reaction conditions on the yield of the protease-catalyzed synthesis of Leu-enkephalin or Leu-enkephalin amide were also investigated.
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