Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 10466-61-2, is researched, Molecular C6H15ClN2O, about Synthesis of 2-methoxy-3-isobutyl pyrazine-(methoxy-13C), the main research direction is isotope labeling methoxy isobutyl pyrazine.Application of 10466-61-2.
In recent years, stable isotope tracer technique plays an important role in metabonomics research. This work was designed through using leucine amide hydrochloride as raw material to perform cyclization reaction with glyoxal to obtain the intermediate 2-hydroxy-3-iso-Bu pyrazine, then preparing 2-chloro-3-iso-Bu pyrazine by chlorination reaction, and preparing 2-methoxy-3-iso-Bu pyrazine-(methoxy-13C) under alk. conditions by condensation reaction with isotope labeling of methanol-13C. The synthetic route could avoid the intermediate from changing from enol to keto and obtain the isomer of the target product. It had the advantages of simple operation, short process flow and less side products. The yield of target compound was more than 70%, and 13C labeled isotope abundance was not diluted The product was confirmed by HPLC, MS, 1HNMR and 13CNMR. The chem. purity was more than 99%, and the deuterium enrichment was more than 98.8 atom% 13C.
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