Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloroethyl acetate, is researched, Molecular C4H7ClO2, CAS is 542-58-5, about Syntheses and reactions of functional polymers. LXXXII. Aminolyses of alkyl acetates containing electron-withdrawing substituents in leaving groups.COA of Formula: C4H7ClO2.
The aminolysis of alkyl acetates AcOCH2R (R = Me, CH2Cl, CH2CN, CCl3) was examined The relative rates in DMF were 1, 37, 87, 2700, resp. Similar relative reactivities were observed in the reaction with H2N(CH2)2NH2 in DMF or with H2N (CH2)2OH in dioxane. The ρ values in all cases were > 3 in Taft’s quantum log (k/k0) = ρ * σ*. A linear relation of log k/k0 with νCO was observed Inductive effects played an important role in the activation of the alkyl acetates. The mechanism was also discussed.
After consulting a lot of data, we found that this compound(542-58-5)COA of Formula: C4H7ClO2 can be used in many types of reactions. And in most cases, this compound has more advantages.