As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is [1,1′-Binaphthalene]-2,2′-diol, and cas is 602-09-5, its synthesis route is as follows.,602-09-5
In a glass reactor equipped with a stirrer, a condenser, and a thermometer,180 g (0.629 mol) of (RS) -1,1′-bi-2-naphthol,127 g (1.439 mol) of ethylene carbonate,9.0 g of potassium carbonate and 180 g of toluene,And reacted at 110 C. for 10 hours. As a result of HPLC measurement,0.1% of 1,1′-bi-2-naphthol,89.4% of 2,2′-bis (2-hydroxyethoxy) -1,1′-binaphthalene,The polymer was 6.9%, the others were 1 mol adduct and 3 mol adduct.620 g of toluene was added to this reaction mixture and diluted,270 g of a 9.7 wt% sodium hydroxide aqueous solution was added to the organic solvent phase containing the reaction mixture, and the mixture was stirred at 85 C. for 1 hour, and then the aqueous phase was separated off and removed.As a result of measuring the organic solvent layer by HPLC,It was 96.2% of 2,2′-bis (2-hydroxyethoxy) -1,1′-binaphthalene, and no polymer was detected.Next, this organic solvent layer was washed with water until the washing water became neutral.After refluxing and dehydrating the obtained organic solvent phase, it was cooled to room temperature, filtered and dried to obtain (RS) -2,2′-bis (2-hydroxyethoxy) -1,1′-binaphthalene as white crystals (Yield 83.6%, HPLC purity 99.6%, YI value: 2.9).
With the complex challenges of chemical substances, we look forward to future research findings about 602-09-5,belong chiral-catalyst compound
Reference£º
Patent; TAOKA CHEMICAL COMPANY LIMITED; MATSUURA, TAKASHI; KAWAMURA, MIO; HIRABAYASHI, SHUNICHI; FUJII, KATSUHIRO; (11 pag.)JP6083901; (2017); B2;,
Chiral Catalysts
Chiral catalysts – SlideShare