23190-16-1, (1R,2S)-2-Amino-1,2-diphenylethanol is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of (Boc)2O (44 mmol) in THF (50ml) was added to the mixture of the amino alcohol (40 mmol) and sodium carbonate (80 mmol) in THF/H2O (1/1, 300 ml) at O0C. The mixture was stirred at O0C for Ih and then at room temperature for another two 2h (TLC was used to monitor the reactions). Water (200 ml) was added to the mixture upon completion. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (200 ml). The combined organic layers was washed with brine (300 ml) and dried with anhydrous MgSO4 for Ih. It was then filtered and the solvent was removed under vacuum to give the product (yield = 90 – 99 %). It was sufficiently pure for the next step. The pure product was obtained by recrystallization from the THF and hexane, or by purification with silica gel chromatography.Example 2.1: Tert-butyl (lS,2R)-2-hydroxy-l,2-diphenylethylcarbamatePh PhBocHN OHYield: 90 %. 1H NMR (CD2Cl2): delta 7.25-7.27 (m, 6H), 7.08-7.1 1 (m, 4H), 5.33 (m, IH), 5.04 (m, IH), 4.92 (b, IH), 2.60 (b, IH), 1.38 (s, 9H).
23190-16-1, 23190-16-1 (1R,2S)-2-Amino-1,2-diphenylethanol 719819, achiral-catalyst compound, is more and more widely used in various fields.
Reference£º
Patent; KANATA CHEMICAL TECHNOLOGIES INC.; WO2008/148202; (2008); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare