The important role of 23190-16-1

With the complex challenges of chemical substances, we look forward to future research findings about (1R,2S)-2-Amino-1,2-diphenylethanol

Name is (1R,2S)-2-Amino-1,2-diphenylethanol, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 23190-16-1, its synthesis route is as follows.,23190-16-1

A solution of HBTU in DMF (1 M, 0.048 ml) was added to a mixture of 3- (3, 5-DIFLUOROPHENYL)-2-PHENYLMETHANESULPHONYLAMINO-PROPIONIC acid (INTERMEDIATE 2, 14 MG, 0.04 MMOL) and (1 R, 2S)-(-)-2-AMINO-1, 2-DIPHENYLETHANOL (10.2 mg, 0.048 mol) in DMF (0.1 ML). The mixture was treated briefly in an ultrasonic bath to ensure complete solution of reagents and the solution was stored at room temperature overnight. Purification by preparative hplc (see Methods) gave the desired product, 8.7 mg (39%), HPIC/MS Rt 5.68 min, M/Z 551.

With the complex challenges of chemical substances, we look forward to future research findings about (1R,2S)-2-Amino-1,2-diphenylethanol

Reference£º
Patent; DE NOVO PHARMACEUTICALS LIMITED; WO2004/20402; (2004); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare