With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-22-8,trans-Cyclohexane-1,2-diamine,as a common compound, the synthetic route is as follows.
General procedure: Salen ligands were obtained in the stoichiometric reaction of salicylic aldehyde and trans-1,2-diaminocyclohexane in 96% ethanol solution according to [13c]. Reactions were carried out in 50 ml three-neck round-bottomed flask, equipped with reflux condenser, dropping funnel, magnetic stirrer and heating mantle. The solution of trans-1,2-diaminocyclohexane (0,57 ml, 5 mmol) in EtOH (10 ml) was slowly added to a hot solution of appropriate aldehyde (10 mmol) in EtOH (20 ml). The reaction mixture was heated at reflux for 1.5 h. After cooling to room temperature, the yellow precipitate that formed was filtered off and washed with cold EtOH (5 ml). The ligands were used without further purification. (¡À)-trans-N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclo-hexanediamine (H2salcn(2Bu)) (H2salcn(BuOMe)) Anal. Calc. for C36H54N2O2: C, 79.07%; H, 9.95%; N, 5.12%; C/N = 15.44. Found: C, 78.98%; H, 10.25%; N, 5.17%; C/N = 15.27. 1H-NMR (CDCl3): delta = 13.70 (bs, 2H), 8.29 (s, 2H), 7.29 (d, J = 2.40 Hz, 2H), 6.97 (d, J = 2.30 Hz, 2H), 3.31 (m, 2H), 1.94 (m, 2H), 1.87 (m, 2H), 1.73 (m, 2H), 1.47 (m, 2H), 1.40 (s, 18H), 1.23 (s, 18H). Yield: 2.19 g, 80%, mp = 178-181 C.
1121-22-8, 1121-22-8 trans-Cyclohexane-1,2-diamine 43806, achiral-catalyst compound, is more and more widely used in various fields.
Reference£º
Article; Tomczyk; Nowak; Bukowski; Bester; Urbaniak; Andrijewski; Olejniczak; Electrochimica Acta; vol. 121; (2014); p. 64 – 77;,
Chiral Catalysts
Chiral catalysts – SlideShare