With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.
A mixtureof the corresponding azolium salt 1a-f (0.55 mmol), pyridineor 3-chloropyridine (4 g), PtCl2 (133 mg, 0.5 mmol), and fi nelyground anhydrous K2CO3 (345 mg, 2.5 mmol) was heated at80 with vigorous stirring for 16 h. In the obtaining of iodidecomplex 2 and bromide complexes 2d-f, fi nely ground KI(498 mg, 3.0 mmol) or KBr (357 mg, 3.0 mmol), respectively,was added to the reaction mixture together with other reactants.Then, the mixture was cooled to room temperature and dilutedwith CH2Cl2 (15 mL), a precipitate formed was fi ltered off . Thesolution was washed with water (3¡Á5 mL), dried with Na2SO4,and passed through a layer of silica gel (height 1 cm, diameter2 cm). The solvent was evaporated on a rotary evaporator,n-hexane (5 mL) was added to the residue, and the mixture wascooled to ~0 C. The precipitate formed was collected by fi ltration,recrystallized from a mixture of CH2Cl2-n-hexane (1 : 2),and dried in vacuo at 40 for 24 h.
141556-45-8, 141556-45-8 1,3-Dimesityl-1H-imidazol-3-ium chloride 2734211, achiral-catalyst compound, is more and more widely used in various fields.
Reference£º
Article; Chikunov; Ranny; Astakhov; Tafeenko; Chernyshev; Russian Chemical Bulletin; vol. 67; 11; (2018); p. 2003 – 2009; Izv. Akad. Nauk, Ser. Khim.; vol. 67; 11; (2018); p. 2003 – 2009,7;,
Chiral Catalysts
Chiral catalysts – SlideShare