Analyzing the synthesis route of 22795-99-9

With the synthetic route has been constantly updated, we look forward to future research findings about (S)-(1-Ethylpyrrolidin-2-yl)methanamine,belong chiral-catalyst compound

As a common heterocyclic compound, it belong chiral-catalyst compound,(S)-(1-Ethylpyrrolidin-2-yl)methanamine,22795-99-9,Molecular formula: C7H16N2,mainly used in chemical industry, its synthesis route is as follows.,22795-99-9

To 22 mg (0.039 mmol) of acid 164 dissolved in DMF (700 muL) was added (S)-2-aminoethyl)-1-ethylpyrrolidine (20 mg, 0.16 mmol), DIEA (27 muL, 0.16 mmol) and HBTU (44 mg, 0.12 mmol). The reaction mixture was stirred at rt for 3 h and then diluted with methanol (800 muL). The crude product was purified by HPLC and fractions containing the desired product were combined and lyophilized to afford 5 mg (20percent) of 156 as a fluffy white solid. MS (ESI(+)) m/e 677.4 (M+H)+.

With the synthetic route has been constantly updated, we look forward to future research findings about (S)-(1-Ethylpyrrolidin-2-yl)methanamine,belong chiral-catalyst compound

Reference£º
Patent; Infinity Pharmaceuticals, Inc.; US2006/25460; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare