With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.
A microwave -vial was loaded with NHC HCl (0.55 mmol), palladium(II) chloride (89 mg, 0.50 mmol), potassium carbonate (345 mg, 2.5 mmol), 3-chloropyridine (2 mL) and a magnetic bar. The mixture was heated in a microwave reactor for 45 min at 200 C. The mixture was diluted with methylene chloride, filtered over a plug of silica gel that was covered with celite and the silica gel was rinsed with methylene chloride. The solvent and excess chloropyridine were removed in vacuo, the product was triturated in pentane and the pentane was decanted. Drying in vacuo afforded the desired products as yellow solids.(IPr)PdCl2(3-chloropyridine):309 mg (88 %) of the title compound were obtained using IPr-HCl (234 mg, 0.550 mmol). 1H NMR (300 MHz, CDCI3): delta (ppm) = 8.60 (d, 3J= 2.4 Hz, 1H), 8.52 (dd, 3J = 5.5 Hz, 3J= 1.3 Hz, 1H), 7.55 (ddd, 3J= 8.2 Hz, 3J= 2.3 Hz, 3J= 1.3 Hz, 1H), 7.50 (t, 3J = 7.8 Hz, 2H), 7.35 (d, 3J= 7.7 Hz, 4H), 7.14 (s, 2H), 7.07 (dd, 3J= 8.2 Hz, 3J= 5.5 Hz), 3.16 (sept, 3J= 6.7 Hz, 4H), 1.48 (d, 3J= 6.6 Hz, 12H), 1.12 (d, 3J= 6.9 Hz, 12H).
250285-32-6 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride 2734913, achiral-catalyst compound, is more and more widely used in various.
Reference£º
Patent; UNIVERSITY OF HAWAII; NAVARRO, Oscar; WINKELMANN, Ole, H.; WO2011/71881; (2011); A2;,
Chiral Catalysts
Chiral catalysts – SlideShare