With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.
Under inert atmosphere, 1,3-bis-(2,6-diisopropylphenyl)imidazolium chloride (1.03 g,1.86 mmol, 1.00 equiv.) was dissolved in dichloromethane/acetonitrile mixture (40 mL, 1:1 v/v)and silver(I) oxide (366 mg, 1.58 mmol, 0.85 equiv.) was added. The mixture was stirred at roomtemperature for 2 d and the solvent was removed in vacuum and the residue was treated withdichloromethane (20 mL) and not soluble material was filtered off. Then, iodine (802 mg,3.16 mmol, 1.70 equiv.) in dichloromethane (20 mL) was added slowly and stirred overnight andthe solvent was removed in vacuum. The crude intermediate, was dissolved in MeOH/H2O(150 mL, 1:2 v/v) and NaOTf (480 mg, 2.79 mmol, 1.50 equiv.) in MeOH/H2O (60 mL, 1:5 v/v)was added. More water (150 mL) was added to complete the precipitation. The solid was filteredoff and was recrystallized from CH2Cl2/MTBE to give C6-OTf (700 mg, 1.05 mmol, 57 %).
250285-32-6 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride 2734913, achiral-catalyst compound, is more and more widely used in various.
Reference£º
Article; Von Der Heiden, Daniel; Detmar, Eric; Kuchta, Robert; Breugst, Martin; Synlett; vol. 29; 10; (2018); p. 1307 – 1313;,
Chiral Catalysts
Chiral catalysts – SlideShare