As a common heterocyclic compound, it belong chiral-catalyst compound,[1,1′-Binaphthalene]-2,2′-diol,602-09-5,Molecular formula: C20H14O2,mainly used in chemical industry, its synthesis route is as follows.,602-09-5
The reaction was carried out in an ice bath. Tetrahydrofuran (30 mL) was added to a solution of sodium hydride (1.92 g, 80 mmol)Three-necked flask. A solution of 1,1′-binaphthol (compound (1)) (10 g, 34 mmol) in tetrahydrofuran (50 mL) was dissolvedThe solution was slowly added dropwise to the reaction solution over a period of 20 minutes. After completion of the addition, the reaction was continued for 30 minutes, and then chloromethyl ether (6.4 g, 80 mmol) was slowly added dropwise to the reaction solution. The reaction was continued for about one hour and monitored by thin layer chromatography. After the reaction was complete, the reaction was quenched with water (20 mL). The organic material was extracted with dichloromethane and water and the solvent was removed. The compound (2) was isolated by column chromatography on silica gel using a mixture of petroleum ether and ethyl acetate (5: 1) as the eluent. Yield: 90%.
With the synthetic route has been constantly updated, we look forward to future research findings about [1,1′-Binaphthalene]-2,2′-diol,belong chiral-catalyst compound
Reference£º
Patent; East China University of Science and Technology; LILIES GROUP CO., LTD; Wang, Limin; Wu, Shengming; Zhang, Kewei; Wang, Feng; Wang, Guifeng; Tian, He; Wang, Zhenyan; Chen, Lirong; Huang, Zhuo; (23 pag.)CN104478915; (2016); B;,
Chiral Catalysts
Chiral catalysts – SlideShare