With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.673-06-3,D-Phenylalanine,as a common compound, the synthetic route is as follows.
673-06-3, General procedure: The amino acid of configuration (R)- (39.3 mmol) is solubilized in 50 ml of water. At 0 C., KBr (3.5 eq, 31.8 g) and then H2SO4 (7.73 ml), respectively, are added dropwise, while maintaining the temperature below 5 C. The mixture is cooled to -10 C. and NaNO2 (1.3 eq, 3.59 g) solubilized in 17 ml of water is added dropwise. The mixture is stirred for 2 hours at -5 C. (0196) After returning to room temperature, the mixture is extracted with CH2Cl2 (2¡Á50 ml). The organic phase is washed with H2O, saturated NaCl, dried on Na2SO4 to yield the expected product of configuration (R). (0197) 3a R2=CH2Ph: light yellow oil; (Yield: 50%); Rf (CH2Cl2/MeOH): 0.62 (0198) NMR (CDCl3, 200 MHz): 3.15-3.40 (2H, dd); 4.69 (1H, m); 7.20-7.40 (5H, m)
673-06-3 D-Phenylalanine 71567, achiral-catalyst compound, is more and more widely used in various fields.
Reference£º
Patent; PHARMALEADS; ROQUES, Bernard Pierre; FOURNIE-ZALUSKI, Marie-Claude; PORAS, Herve; US2015/299116; (2015); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare