7181-87-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7181-87-5,1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide,as a common compound, the synthetic route is as follows.
Additions: [0291] 0.6 gram of a Karstedt solution containing 16.2% platinum, i.e. 0.5 mmol of platinum, [0292] 137 mg of N,N-dimethylbenzimidazolium iodide, i.e. 0.5 mmol (1. 0 equiv.) (A,B,T3,T4=benzyl; T1T2=methyl), [0293] 112 mg of potassium tert-butoxide, i.e. 1 mmol (2 equiv.) [0294] 20 ml of dry THF. [0295] The solution of the Karstedt complex and the benzimidazolium salt are placed in the round-bottomed flask and then diluted in 20 ml of THF. The potassium tert-butoxide is added at room temperature and the mixture is stirred for 36 hours in the absence of light. The reaction medium is diluted in dichloromethane and then washed with water. The solvent is evaporated off and the oil obtained is rapidly filtered through silica gel (eluent: CH2Cl2). After evaporating off the solvent, the solid obtained is rinsed with two milliliters of hexamethyldisiloxane. 173 mg (66% yield) of an analytically pure white solid are obtained.
7181-87-5 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide 11821793, achiral-catalyst compound, is more and more widely used in various fields.
Reference£º
Patent; Buisine, Olivier; Marko, Istvan; Sterin, Sebastien; US2004/198996; (2004); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare