Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Molecular-Iodine-Mediated, Efficient One-Pot Synthesis of 2-Iminohydantoins and 2-Amino-1H-imidazol-4(5H)-ones by Cyclodeselenization of Selenourea-Tethered Amides/Peptides.Reference of H-Leu-NH2.HCl.
An efficient one-pot synthesis of 2-iminohydantoins e.g., I and 2-amino-1H-imidazol-4(5H)-ones e.g., II via iodine mediated intramol. cyclodeselenization of intermediate selenourea tethered amides/peptides was described. The method employs selenophilic ability of environmentally benign iodine to effect the deselenization at room temperature, thereby avoiding harsh conditions that are generally employed in the synthesis of iminohydantoins. Significantly 2-(N-alkylamino)-1H-imidazol-4(5H)-ones and 2-iminohydantoin conjugates of ditripeptide I and tripeptide III could be synthesized. Other advantages of the method include mild condition, short duration, wide substrate scope, simple workup and purification of the products.
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