The chiral-catalyst compound, name is trans-Cyclohexane-1,2-diamine,cas is 1121-22-8, mainly used in chemical industry, its synthesis route is as follows.,1121-22-8
General procedure: A methanolic solution (10mL) of (¡À)-trans-1,2-diaminocyclohexane (dach) (0.23g, 2.0mmol), in a Schlenk tube, was added drop-wise to a methanolic solution (20mL) of substituted salicylaldehyde-imidazolium salt H(R1)sal(Im+-R2R3-Cl-) 3a-f (4.0mmol) into a 100ml Schlenk flask under nitrogen atmosphere. The reaction mixture was stirred at 60C overnight. MeOH was partially removed under reduced pressure on a rotary evaporator, and the yellow products of 4a-f were precipitated by ethyl acetate and kept in the refrigerator overnight. The precipitate was sonicated with Et2O (3¡Á25mL), collected by filtration and dried under vacuum.
As the rapid development of chemical substances, we look forward to future research findings about 1121-22-8
Reference£º
Article; Elshaarawy, Reda F.M.; Janiak, Christoph; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 31 – 42;,
Chiral Catalysts
Chiral catalysts – SlideShare