A common heterocyclic compound, the chiral-catalyst compound, name is Benzo-18-crown 6-Ether,cas is 14098-24-9, mainly used in chemical industry, its synthesis route is as follows.,14098-24-9
A mixture of 0.27 g OfMo(CO)6 (1.03 mmol), 0.12 g of KBr (1.00 mmol) and 0.31 g of benzo-18-crown-6-ether (1.00 mmol) was refluxed in 15 ml of freshly distilled THF for 2 hours. The yellow solution was filtered and a brown oil formed and started to separate. After decanting the oil, 40 ml of hexane were added and the schlenk was left at 0 0C to isolate a yellow solid. Extraction with CH2Cl2 afforded K[benzo-18-crown-6-ether][Mo(CO)5Br] as yellow needles (75% yield , 0.5 g).Analysis Calculated for BrC21H24KMo11: C, 37.80; H, 3.62. Found: C, 37.25; H5 3.83. IR (KBr pellet), cm4: 3069 (w), 2955 (m), 2941 (m), 2921 (m), 2067 (m), 1977 (w), 1932 (sh, s), 1914 (s), 1842 (s), 1834 (s), 1638 (br, w), 1596 (w), 1523 (w), 1505 (s), 1478 (w), 1457 (m), 1436 (w), 1382 (w), 1355 (m), 1343 (m), 1325 (m), 1286 (m), 1247 (s), 1214 (s), 1178 (br, sh5 w), 1166 (w), 1126 (m), 1116 (m), 1108 (m), 1097 (sh, w), 1083 (w), 1075 (w), 1055 (w), 961 (m), 952 (m), 935 (w), 922 (w), 908 (w), 882 (w), 860 (w), 848 (w), 833 (w), 806 (br, w), 782 (m), 737 (s), 598 (s), 542 (m), 507 (w), 463 (w). 1H NMR (CD2Cl2, 300 MHz): 7.00-6.90 (c, 4H, C6H4 crown ether), 4.22 + 3.95 + 3.77-3.42 (c, 1OH, aliphatic crown ether protons).
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Reference£º
Patent; ALFAMA – INVESTIGACAO E DESENVOLVIMENTO DE PRODUTOS FARMACEUTICOS LDA.; WO2007/73225; (2007); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare