A common heterocyclic compound, the chiral-catalyst compound, name is (S)-(1-Ethylpyrrolidin-2-yl)methanamine,cas is 22795-99-9, mainly used in chemical industry, its synthesis route is as follows.,22795-99-9
General procedure: To a well-stirred solution of 83 4-chloroaniline (a2) (0.57g, 4.5mmol) and 84 NEt3 (5mL) in dry 28 DCM (25mL) was added dropwise a solution of compound 26 10 (0.51g, 2.0mmol) at room temperature. The reaction mixture was stirred at room temperature for 14h. The crude mixture was obtained by removal of the organic solvents under reduced pressure and was re-dissolved in DCM, followed by washing with H2O for 3 times. The organic layers were combined, dried over anhydrous MgSO4, filtered and concentrated in vacuum. Purification of the product was performed by flash column chromatography on silica gel to afford the desired 85 compound 11_a2 (0.28g) in 45percent yield.
As the rapid development of chemical substances, we look forward to future research findings about 22795-99-9
Reference£º
Article; Jin, Wen Bin; Xu, Chen; Cheng, Qipeng; Qi, Xiao Lin; Gao, Wei; Zheng, Zhiwei; Chan, Edward W.C.; Leung, Yun-Chung; Chan, Tak Hang; Wong, Kwok-Yin; Chen, Sheng; Chan, Kin-Fai; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 285 – 302;,
Chiral Catalysts
Chiral catalysts – SlideShare