Application of 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid

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A common heterocyclic compound, the chiral-catalyst compound, name is (S)-(1-Ethylpyrrolidin-2-yl)methanamine,cas is 22795-99-9, mainly used in chemical industry, its synthesis route is as follows.,22795-99-9

General procedure: Step 2. 3-(Benzylamino)- or 3-(arylamino)-4-methoxycyclobut-3-ene-1,2-dione 18a ? 18f (1.0 equiv.) was suspended in MeOH (0.07 M) and the amine 19a, 19b or 19c (1.0 equiv.) was added. The resulting mixture was stirred at ambient temperature for 24 hours. The mixture was then filtered and the collected solid residue was washed with ice-cold MeOH and dried in vacuo to afford the corresponding squaramides 1 ? 6.

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Reference£º
Article; Kristianslund, Renate; Aursnes, Marius; Tungen, J¡ãrn Eivind; Hansen, Trond Vidar; Tetrahedron Letters; vol. 57; 47; (2016); p. 5232 – 5236;,
Chiral Catalysts
Chiral catalysts – SlideShare