The chiral-catalyst compound, cas is 14098-24-9 name is Benzo-18-crown 6-Ether, mainly used in chemical industry, its synthesis route is as follows.,14098-24-9
A mixture of chloroform (50 ml) and acetic acid (50 ml) were charged in 250 ml round bottom flask. The monobenzo 18-crown-6 ether was added in to the mixture and stirred well. Afterword 8.5 ml nitric acid (70%) slowly dropwise added over a period of 30 min and stirring was continued at RT for additional 24 hr. Then the mixture was neutralized with aqueous Na2CO3 and the reaction product in to aqueous layer extract with chloroform (70 ml x 3). The combined chloroform layer dried by Na2SO4 and evaporated on rotary evaporator observed a yellow crude solid. Crude solid was recrystallized in ethanol to furnish a pure nitro product. Yield: 77%; m.p. 69-71C (Lit.70-72C).
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Reference£º
Article; Patil, Dayanand R.; Chandam, Dattatraya R.; Mulik, Abhijeet G.; Jagdale, Suryabala D.; Patil, Prasad P.; Deshmukh, Madhukar B.; Synthetic Communications; vol. 45; 16; (2015); p. 1902 – 1911;,
Chiral Catalysts
Chiral catalysts – SlideShare