The chiral-catalyst compound, cas is 673-06-3 name is D-Phenylalanine, mainly used in chemical industry, its synthesis route is as follows.,673-06-3
To a dry flask were added (R) -phenylalanine (4.2 g, 25 mmol) , water (30 mL) , 1, 4-dioxane (30 mL) and sodium bicarbonate (5.1 g, 61 mmol) in turn, After stirring for 10 min, (Boc) 2O (10.1 g, 45.8 mmol) was added. The resulting mixture was stirred at rt for 24 hours. After the reaction was completed, the mixture was concentrated in vacuo to remove the solvent. The residue was diluted with water (20 mL) and EtOAc (100 mL) , and adjusted with HCl (1 M) to pH 6-7. The resulting mixture was stood to separate into layers, the organic layer was washed with saturated aqueous NaCl and dried over anhydrous sodium sulfate, filtered. The filtrate was concentrated in vacuo to remove the solvent to get the title compound as a colorless oil (6.0g, 91%) . MS (ESI, pos. ion) m/z: 288.2 [M+Na] +.
As the rapid development of chemical substances, we look forward to future research findings about 673-06-3
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Xinchang; REN, Qingyun; YAN, Guanghua; GOLDMANN, Siegfried; ZHANG, Yingjun; (253 pag.)WO2019/76310; (2019); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare